Dioxole related

Islam, M. Tofazzal published the artcileRepellent activity of estrogenic compounds toward zoospores of the phytopathogenic fungus Aphanomyces cochlioides, Synthetic Route of 110204-45-0, the publication is Zeitschrift fuer Naturforschung, C: Journal of Biosciences (2001), 56(3/4), 253-261, database is CAplus and MEDLINE.

Bisphenol A, showed potent repellent activity against the zoospores of Aphanomyces cochlioides. Based on this finding, a number of androgenic and estrogenic compounds (e.g. testosterone, progesterone, estradiols, diethylstilbestrol, estrone, estriol, pregnenolone, dienestrol etc.) were tested on the motility behavior of A. cochlioides zoospores. Most of the estrogenic compounds exhibited potent repellent activity (1 μg/mL or less by the “particle method”) toward the motile zoospores of A. cochlioides. The authors derivatized some of the estrogens and discussed the relationship between the structure of active mols. and their repellent activity. Aromatization of the A ring with a free hydroxyl group at C-3 position of a steroidal structure is necessary for higher repellent activity. Methylation of diethylstilbestrol (DES) yielded completely different activity i.e. both mono- and di-Me ethers of DES showed attractant activity. The attracted zoospores were encysted and then germinated in the presence of di-Me ether of DES. The potential usefulness of this repellent test is discussed for the detection of estrogenic activity of naturally occurring compounds, and the possible role of phytoestrogens in host/parasite interactions.

Zeitschrift fuer Naturforschung, C: Journal of Biosciences published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, Synthetic Route of 110204-45-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Papachristos, M. J. published the artcileThe effect of the molecular structure of antiknock additives on engine performance, COA of Formula: C6H12O2, the publication is Journal of the Institute of Energy (1991), 64(459), 113-23, database is CAplus.

The effects of the mol. structured of gasoline additives on fuel octane rating, engine efficiency, and exhaust emissions were studied. In addition to a reassessment of known high-octane components, a new chem. mechanistic model was developed to explain antiknock characteristics. This fundamental model led to the prediction of several new classes of potential antiknock compounds Some excellent antiknock components were identified, and a number of new correlations between mol. structure and blending antiknock performance were established on a standard single-cylinder engine; they were in line with the predictions of the developed model. The effects of the above compounds on engine antiknock performance, efficiency, and exhaust emissions (including aldehydes), were investigated on a fully instrumented test 4-cylinder engine. The single-cylinder test results were largely confirmed by careful data anal., and all engine effects were eliminated, thereby enabling further clear-cut correlations to be established between mol. structure, engine efficiency and exhaust emissions. Two components, dipentene and N–tert-butylfurfurylamine, were identified as the most promising gasoline supplements.

Journal of the Institute of Energy published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, COA of Formula: C6H12O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Gerloff, Janice published the artcileInflammatory Response and Barrier Dysfunction by Different e-Cigarette Flavoring Chemicals Identified by Gas Chromatography-Mass Spectrometry in e-Liquids and e-Vapors on Human Lung Epithelial Cells and Fibroblasts, SDS of cas: 68527-74-2, the publication is Applied In Vitro Toxicology (2017), 3(1), 28-40, database is CAplus and MEDLINE.

Recent studies suggest that electronic cigarette (e-cig) flavors can be harmful to lung tissue by imposing oxidative stress and inflammatory responses. The potential inflammatory response by lung epithelial cells and fibroblasts exposed to e-cig flavoring chems. in addition to other risk-anticipated flavor enhancers inhaled by e-cig users is not known. The goal of this study was to evaluate the release of the proinflammatory cytokine (interleukin-8 [IL-8]) and epithelial barrier function in response to different e-cig flavoring chems. identified in various e-cig e-liquid flavorings and vapors by chem. characterization using gas chromatog.-mass spectrometry anal. Flavorings, such as acetoin (butter), diacetyl, pentanedione, maltol (malt), ortho-vanillin (vanilla), coumarin, and cinnamaldehyde in comparison with tumor necrosis factor alpha (TNFα), were used in this study. Human bronchial epithelial cells (Beas2B), human mucoepidermoid carcinoma epithelial cells (H292), and human lung fibroblasts (HFL-1) were treated with each flavoring chem. for 24 h. The cells and conditioned media were then collected and analyzed for toxicity (viability %), lung epithelial barrier function, and proinflammatory cytokine IL-8 release. Cell viability was not significantly affected by any of the flavoring chems. tested at a concentration of 10μM to 1 mM. Acetoin and diacetyl treatment induced IL-8 release in Beas2B cells. Acetoin- and pentanedione-treated HFL-1 cells produced a differential, but significant response for IL-8 release compared to controls and TNFα. Flavorings, such as ortho-vanillin and maltol, induced IL-8 release in Beas2B cells, but not in H292 cells. Of all the flavoring chems. tested, acetoin and maltol were more potent inducers of IL-8 release than TNFα in Beas2B and HFL-1 cells. Flavoring chems. rapidly impaired epithelial barrier function in human bronchial epithelial cells (16-HBE) as measured by elec. cell surface impedance sensing. Our findings suggest that some of the e-cig liquids/aerosols containing flavoring chems. can cause significant loss of epithelial barrier function and proinflammatory response in lung cells.

Applied In Vitro Toxicology published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, SDS of cas: 68527-74-2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Tang, Weijun published the artcileHighly efficient and enantioselective hydrogenation of quinolines and pyridines with Ir-Difluorphos catalyst, HPLC of Formula: 503538-69-0, the publication is Organic & Biomolecular Chemistry (2010), 8(15), 3464-3471, database is CAplus and MEDLINE.

The combination of the readily available chiral bisphosphine ligand Difluorphos with [Ir(COD)Cl]₂ in THF resulted in a highly efficient catalyst system for asym. hydrogenation of quinolines at quite low catalyst loadings (0.05-0.002 mol%), affording the corresponding products with high enantioselectivities (up to 96%), excellent catalytic activities (TOF up to 3510 h^-1) and productivities (TON up to 43000). The same catalyst was also successfully applied to the asym. hydrogenation of trisubstituted pyridines with nearly quant. yields and up to 98% ee. In these two reactions, the addition of I₂ additive is indispensable; but the amount of I₂ has a different effect on catalytic performance.

Organic & Biomolecular Chemistry published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C2H4ClNO, HPLC of Formula: 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Alame, Mohamad published the artcileExtensive re-investigations of pressure effects in rhodium-catalyzed asymmetric hydrogenations, COA of Formula: C38H24F4O4P2, the publication is Advanced Synthesis & Catalysis (2008), 350(6), 898-908, database is CAplus.

The catalytic hydrogenation of three prochiral substrates Me Z-α-acetamidocinnamate (MAC), Me 2-acetamidoacrylate (M-Acrylate) and Et 4-methyl-3-acetamido-2-propanoate (E-EMAP) with rhodium precursors complexed with chiral diphosphines is reported at 1-30 bar hydrogen pressure. A library of 56 chiral diphosphines, including 23 BINAP derivatives, 7 JOSIPHOS, 5 BIPHEP, 3 DUPHOS derivatives, and 18 other ligands, was used. While it was generally accepted that high hydrogen pressure would result in lower ees, it is now demonstrated on a statistical basis that an equivalent distribution between beneficial and detrimental pressure effects on ee prevails and that the hydrogen pressure effect on enantioselectivity is not an isolated phenomenon since more than 33% of the reaction systems studied are strongly affected. In some case, the enantioselectivity can be improved up to 97% just by applying a higher hydrogen pressure. Extension of these conclusions to other non-chiral reagents is proposed.

Advanced Synthesis & Catalysis published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, COA of Formula: C38H24F4O4P2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Menard, Frederic published the artcileLigand-Controlled Selectivity in the Desymmetrization of meso Cyclopenten-1,4-diols via Rhodium(I)-Catalyzed Addition of Arylboronic Acids, SDS of cas: 503538-69-0, the publication is Journal of Organic Chemistry (2010), 75(12), 4056-4068, database is CAplus and MEDLINE.

A highly enantioselective desymmetrization of meso cyclopent-2-ene-1,4-diethyl dicarbonates has been developed using a Rh-catalyzed asym. allylic substitution. Depending on the type of ligand used, each of two regioisomeric products can be obtained in good yield and excellent enantioselectivity. Under rhodium(I) catalysis, bisphosphine P-Phos ligands form trans-1,2-arylcyclopentenols as the major product, whereas Segphos ligands lead predominantly to trans-1,4-arylcyclopentenols.

Journal of Organic Chemistry published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, SDS of cas: 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Fasi, Andras published the artcileThe ring opening and oligomerization reactions of an epoxide and an episulfide on aluminosilicates in the liquid phase, Formula: C6H12O2, the publication is Central European Journal of Chemistry (2005), 3(2), 230-244, database is CAplus.

The ring opening reactions of propylene oxide (methyloxirane) or ethylene sulfide (thiirane) were studied in the liquid phase over HZSM-5, HY-FAU or AlMCM-41 at 363 K or 423 K and under 1 or 20 bar pressure in a batch reactor. The proportion of these routes were identified: (i) single C-O scission providing non-cyclic products, (ii) double C-O cleavage leading to the loss of the heteroatom, (iii) oligomerization resulting in cyclic dimers and the trimer of thiirane and a non-cyclic dimer of methyloxirane. The reaction pathway depended on the conditions and the solid acids used. Findings are compared to those in the gas phase over the same solid acids. Transformation mechanisms are also suggested.

Central European Journal of Chemistry published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Formula: C6H12O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Fasi, Andras published the artcileRing-Opening and Dimerization Reactions of Methyl- and Dimethyloxiranes on HZSM-5 and CuZSM-5 Zeolites, COA of Formula: C6H12O2, the publication is Journal of Catalysis (1999), 188(2), 385-392, database is CAplus.

Ring-opening and dimerization reactions of methyloxirane and cis- and trans-2,3-dimethyloxirane were studied on CuZSM-5, prepared by various methods, and HZSM-5 zeolites in a closed static recirculation reactor at 363 K in a reductive atm. On these materials two main reaction types, ring-opening and dimerization, could be observed For methyloxirane the major transformation pathways were ring opening and dimerization, producing various dioxolane and dioxane derivatives In addition to these routes 2,3-dimethyloxiranes underwent deoxygenation and rearrangement. The activities and selectivities of the transformations toward these pathways were found to be significantly different depending on the stereochem. of the substrates as well as the nature of the catalysts. Suggestions for the active sites and transformation mechanisms are also offered. (c) 1999 Academic Press.

Journal of Catalysis published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, COA of Formula: C6H12O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Fasi, A. published the artcileRing opening reactions of methyloxirane over DZSM-5 and DAlMCM-41 molecular sieves – a mechanistic study, Product Details of C6H12O2, the publication is Studies in Surface Science and Catalysis (2001), 3678-3685, database is CAplus.

The ring opening reactions of methyloxirane on DZSM-5 and DAlMCM-41 aluminosilicates were studied in a pulse microreactor at 363 K. Deuterium distribution in the products was monitored Single C-O scission as well as dimerization occurred on both mol. sieves. In these reactions Bronsted and Lewis sites were involved Deuterium distribution revealed details of transformation pathways. It was found the main reaction channel, where deuterium exchange does not occur, involves exclusively the Lewis sites at the potential exchange sites. For deuterium exchange to occur during ring opening at least one Bronsted site is necessary. For dimerization when deuterium exchange takes place many active site combinations may be envisaged, however, for the formation of the dioxolane derivatives two neighboring Bronsted-Lewis site pairs, while for the formation of dioxane derivatives the interplay of one Bronsted-Lewis acid pair and a Lewis-Lewis acid pair seem to be the most advantageous.

Studies in Surface Science and Catalysis published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Product Details of C6H12O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Cirkva, Vladimir published the artcileRadical addition reactions of fluorinated species. Part 7. Highly selective two-step synthesis of 1-(polyfluoroalkyl)ethane-1,2-diols; regioselectivity of the additions of methylated 1,3-dioxolanes to perfluoroolefins, Computed Properties of 1193-11-9, the publication is Journal of Fluorine Chemistry (1999), 94(2), 141-156, database is CAplus.

The two-step synthesis of the diols is based on the radical addition of 2,2-dimethyl-1,3-dioxolane, a protected ethane-1,2-diol, to perfluoroalk-1-enes R_F-CF:CF₂ (R_F = CF₃, C₉F₁₉) and perfluoro[trifluorovinyl (poly)ethers] R_FO-CF:CF₂ (R_F = C₃F₇, C₃F₇O[CF(CF₃)CF₂], CF₃(OCF₂CF₂)₄) with preparative yields above 90% in each step. The additions were initiated photochem. or by dibenzoyl peroxide and were completely chemoselective and almost completely regioselective. 4-Fluoroalkylated dioxolanes obtained, e.g., I, were deprotected by acid methanolysis to afford 1-polyfluoroalkylethane-1,2-diols, e.g., HOCH₃CH(OH)CF₂CHFCF₃. 1,3-Dioxolane or 2,2,4-trimethyl-1,3-dioxolane reacted at two centers to yield regioisomeric mixtures of fluoroalkylated dioxolanes. The factors influencing fluoroolefin and dioxolane regioselectivity are discussed.

Journal of Fluorine Chemistry published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Computed Properties of 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem