Category: Dioxole

Synthesis technology of fructone was written by Wang, Qing-ning;Zhang, Lei;Fang, Ming-feng;Jiang, Rui-yu. And the article was included in Riyong Huaxue Gongye in 2008.HPLC of Formula: 6413-10-1 The following contents are mentioned in the article:

Using acid-treated attapulgite clay as supporter, attapulgite clay supported phosphotungstic acid catalyst were prepared through impregnation method, and characterized by XRD, IR and UV spectrophotometry. Such catalyst was used for synthesis of fructone. Effects of molar ratio of Et acetoacetate to glycol, the dosage of catalyst, the dosage of water stripping agent, the reaction time, the reaction temperature on the esterification yield were investigated. The exptl. results showed that attapulgite clay supported phosphotungstic acid catalyst has good catalytic activity, structural stability, and can be reused. Optimum conditions for the synthesis are; molar ratio of Et acetoacetate to glycol is 1.0 = 1.5; the dosage of catalyst is 2 g; the amount of benzene as water stripping agent is 50 mL; the reaction time is 3 h; the reaction temperature is 110°. Its yield achieves higher than 89.7%. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1HPLC of Formula: 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.HPLC of Formula: 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Modeling ready biodegradability of fragrance materials was written by Ceriani, Lidia;Papa, Ester;Kovarich, Simona;Boethling, Robert;Gramatica, Paola. And the article was included in Environmental Toxicology and Chemistry in 2015.Related Products of 6413-10-1 The following contents are mentioned in the article:

Here, quant. structure activity relations were developed for predicting ready biodegradability of ∼200 heterogeneous fragrance materials. Two classification methods, classification and regression tree (CART) and k-nearest neighbors (kNN), were applied to perform the modeling. The models were validated with multiple external prediction sets, and the structural applicability domain was verified by the leverage approach. The best models had good sensitivity (internal ≥80%; external ≥68%), specificity (internal ≥80%; external 73%), and overall accuracy (≥75%). Results from the comparison with BIOWIN global models, based on group contribution method, show that specific models developed in this study perform better in prediction than BIOWIN6, in particular for the correct classification of not readily biodegradable fragrance materials. Environ Toxicol Chem 2015;9999:1-8. © 2015 SETAC. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Related Products of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Studies on catalytic synthesis of fructone by L-proline ionic liquid was written by Liu, Wenmin;Ding, Chenghua;Xing, Wenru;Shi, Xuejun;Liu, Yang. And the article was included in Nanyang Shifan Xueyuan Xuebao in 2010.Recommanded Product: 6413-10-1 The following contents are mentioned in the article:

The synthesis of fructone from Et acetoacetate and ethylene glycol using L-proline ionic liquid as catalyst was investigated. Various reaction parameters such as ratio of Et acetoacetate to ethylene glycol, catalyst amount, the catalyst dosage, the effects of the sort of water-carrying agent and the water-carrying agent amount and reaction time on the product yield were investigated in details. The exptl. results indicated that the molar ratio of Et acetoacetate to ethylene glycol was 1.0:1.4, the quantity of catalyst was equal to 2.0 g/mol Et acetoacetate, amount of cyclohexane was 40 mL, and the reaction time was 3.5 h. The yield of fructone reached 88.9% under the optimum condition. The isolation of the desired products could be achieved via simple separation and ionic liquids could be reused. The catalytic activity was not decreased obviously after recycling for 4 times. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Recommanded Product: 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Hetaryl derivatives of 7-deazapurine ribonucleosides: potent cytostatic agents was written by Perlikova, Pavla;Naus, Petr;Bourderioux, Aurelie;Hocek, Michal. And the article was included in Collection Symposium Series in 2011.Application In Synthesis of ((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol The following contents are mentioned in the article:

A symposium. A series of novel 7-deazapurine ribonucleosides substituted with aryl and hetaryl groups has been prepared Suzuki or Stille cross-coupling reactions with 6-chloro-7-deazapurine ribonucleosides substituted with H, F of Cl atom in position 7 were used in the key step of the synthesis. Either cross-coupling of protected ribonucleoside with appropriate (het)aryl-boronic acid or stannane followed by deprotection, or single-step aqueous-phase Suzuki cross-coupling reaction of unprotected 7-deazapurine ribonucleoside with boronic acid provided target (het)aryl-7-deazapurine ribonucleosides. 6-Furyl- and 6-thienyl-7-deazapurine ribonucleosides showed cytostatic effect in multiple cancer cell lines in nano-molar range. Application of cyclosaligenyl and alanyl-ester phosphoramidate prodrugs did not improved cytostatic activity of parent nucleosides. This study involved multiple reactions and reactants, such as ((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (cas: 158078-04-7Application In Synthesis of ((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol).

((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (cas: 158078-04-7) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of ((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Studies on catalytic synthesis of fructone with modified fly ash was written by Liu, Xianxiang;Yin, Dulin;Yang, Yongjun;Zuo, Chuanpeng;Wang, Jihui. And the article was included in Riyong Huaxuepin Kexue in 2009.Category: dioxole The following contents are mentioned in the article:

The synthesis of fructone from Et acetoacetate and ethylene glycol using fly ash modified by ammonium persulfate as solid acid catalyst was investigated. Various reaction parameters such as reaction time, ratio of Et acetoacetate to ethylene glycol, catalyst amount and water-carrying reagent amount were studied. The optimum reaction conditions were as follows: the molar ratio of Et acetoacetate to ethylene glycol 1:1.8, the quantity of catalyst 1.5 weight% by weight of Et acetoacetate, amount of cyclohexane 15 mL, and the reaction time 3 h. Under this optimum condition, the yield of fructone reaches 95.9%. The exptl. results showed that fly ash modified by ammonium persulfate was an excellent catalyst for synthesis of fructone. Compared with other acid catalysts, the sulfonated activated carbon has higher activity, less used quantity and reusability. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Category: dioxole).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of 2-methyl-2-ethyl acetoacetate-1,3-dioxolane with iodine was written by Yang, Shuijin;Tong, Wenlong. And the article was included in Jingxi Shiyou Huagong Jinzhan in 2008.Reference of 6413-10-1 The following contents are mentioned in the article:

In this paper, 2-methyl-2-Et acetoacetate-1, 3-dioxolane was synthesized from Et acetoacetate and ethylene glycol using I₂ as catalyst. The effects of molar ratio of Et acetoacetate to ethylene, the catalyst dosage and reaction time on the yield of 2-methyl-2-Et acetoacetate-1,3-dioxolane were investigated. Comparison of catalytic activity of different catalysts was made. Exptl. result showed that yield of 2-methyl-2-Et acetoacetate-1,3-dioxolane could reach 73.2 % under the conditions as follows: molar ratio of Et acetoacetate to ethylene 1:1.8, the dosage of catalyst 0.3 % based on feed stocks, cyclohexane as carrying-water reagent, and the reaction time 1.0 h. The catalyst had a fairly high catalytic activity for the ketalization reaction, and had the characteristics in short reaction time, less catalyst dosage and high yield. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Reference of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Reference of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Enantioselective microbial hydrolysis of dissymmetrical cyclic carbonates with disubstitution was written by Nogawa, Masaki;Sugawara, Satomi;Iizuka, Rie;Shimojo, Megumi;Ohta, Hiromichi;Hatanaka, Minoru;Matsumoto, Kazutsugu. And the article was included in Tetrahedron in 2006.Product Details of 6413-10-1 The following contents are mentioned in the article:

Enantioselective microbial hydrolysis of C₁ and C₂ dissym. cyclic carbonates with disubstitution (Me and another groups) has been developed. Pseudomonas diminuta (FU0090), a bacterium, efficiently catalyzes the hydrolysis of five-membered cyclic carbonates. While the trans-substrates are hydrolyzed with low enantioselectivities and/or reactivities, the microbe hydrolyzes the cis-substrates with very high enantioselectivities to afford the corresponding almost optically pure anti-(2R,3S)-diols. On the other hand, six-membered trans-cyclic carbonates are enantioselectively hydrolyzed to afford the corresponding optically active syn-(2R,4R)-diols, although the hydrolysis of the cis-substrates gives racemic compounds In all cases, the enzyme prefers the (R)-enantiomer for the carbon atom bearing a Me group. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Product Details of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and biological activities of new compounds having a 1,3-dioxol[4,5-g]quinoline structure was written by Pellerano, C.;Savini, L.. And the article was included in Farmaco, Edizione Scientifica in 1984.Category: dioxole The following contents are mentioned in the article:

Four substituted 1,3-dioxol[4,5-g]quinolines (I; R = OH, Cl, SH or NHHN₂) were prepared by heat cyclization of Et β–(3,4-methylenedioxyphenylamino)crotonate  [91918-88-6], followed by substitution of the R groups. By reaction of I (R = NHNH₂) with a wide variety of carbonyl compounds, 26 corresponding hydrazones (II) were obtained. All the compounds were tested for antimicrobial activity in vitro and antitumor activity (P388 lymphocytic leukemia) in mice. Most II had good activity against gram-pos. bacteria but not against gram-neg. bacteria, fungi, or Trichomonas vaginalis. I and II were inactive against the tumor. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Category: dioxole).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of fructone by a new solid sulfonic acid sulfonated activated carbon was written by Xu, Qiong;Yin, Dulin;Zhong, Wenzhou;Peng, Chuanzhi;Wang, Jihui. And the article was included in Xiangliao Xiangjing Huazhuangpin in 2007.Reference of 6413-10-1 The following contents are mentioned in the article:

Synthesis of fructone from Et acetoacetate and ethylene glycol using sulfonated activated carbon as solid acid catalyst was investigated. Various reaction parameters such as ratio of Et acetoacetate to ethylene glycol, catalyst amount, reaction time and water-carrying reagent amount were studied. The optimum reaction conditions were: the molar ratio of Et acetoacetate to ethylene glycol was 1:1.8, the quantity of catalyst was equal to 2% Et acetaoacetate, amount of cyclohexane was 20mL, and the reaction time was 3 h. The yield of fructone reached 93.1%, and its selectivity was nearly 100% under the optimum condition. The sulfonated activated carbon was an excellent catalyst for synthesis of fructone. Compared with other acid catalysts, the sulfonated activated carbon has higher activity, less usage and no pollution. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Reference of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Reference of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Study on catalytic synthesis of fructone was written by Deng, Bin;Zhang, Aihua;Xu, Anwu. And the article was included in Shangqiu Shifan Xueyuan Xuebao in 2009.Reference of 6413-10-1 The following contents are mentioned in the article:

Microwave irradiation was used in the catalytic synthesis of fructone from Et acetoacetate and ethanol using nanometer Y₂O₃ as a catalyst. The influence of microwave irradiation power, microwave irradiation time, mole ratio of ethanol to Et acetoacetate, and the dosage of the catalyst on the reaction was investigated. The optimum reaction conditions determined through orthogonal design were as follows: microwave irradiation power was 400 W, microwave irradiation time 9 min, the mole ratio of ethanol to Et acetoacetate was 1.2 : 1 and the dosage of the catalyst was 2.0 g. Under the optimum reaction conditions the yield of fructone was above 95 %. In summary, the microwave technique promotes the synthesis of fructone with high yield and convenient operation and has extensive utilization. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Reference of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem