Category: Dioxole

Condensation reactions assisted by acidic hydrogen bonded hydroxyl groups in solid tin(ii)hydroxychloride was written by Marakatti, Vijaykumar S.;Shanbhag, Ganapati V.;Halgeri, Anand B.. And the article was included in RSC Advances in 2013.Recommanded Product: 6413-10-1 The following contents are mentioned in the article:

Tin(ii)hydroxychloride is reported as a heterogeneous Bronsted acid catalyst. Sn(OH)Cl was synthesized by a precipitation method and characterized by XRD, FT-IR, ¹H MAS NMR, SEM, TG-DTA and N₂ sorption. The acidity measurements of tin(ii)hydroxychloride by FT-IR pyridine adsorption and ¹H MAS NMR showed the presence of Bronsted acidity. The Bronsted acidity can be attributed to strong hydrogen bonding between the -OH and Cl groups. Sn(OH)Cl showed high activity for important condensation reactions such as the Prins condensation, Claisen-Schmidt condensation and ketalization. The catalytic activity of Sn(OH)Cl was compared with that of SnO, SnO₂ and Sn₂(OH)₂O. The catalyst was recycled three times with a negligible decrease in activity. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Recommanded Product: 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane with iodine doped polyaniline was written by Yang, Shuijin;Yin, Guojun;Lu, Baolan. And the article was included in Jingxi Shiyou Huagong Jinzhan in 2011.Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

2-Methyl-2-ethoxycarbonylmethyl-1,3-dioxolane was synthesized by the reaction of Et acetylacetate with glycol with I₂/PAn as the catalyst, and the effect of I₂/PAn on the catalytic activity of ketal reaction as well as the effect of molar ratio of materials, catalyst usage and reaction time on product yield were studied. According to the results, I₂/PAn is a good catalyst for synthesizing 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane. The optimum reaction conditions were identified, i.e. n(Et acetylacetate):n(glycol) = 1:1.6, percentage of catalyst amount in total mass of reaction materials: 0.6%, water carrying agent: cyclohexane, and reaction time: 45 min. The yield of 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane can reach 86.2% at above conditions. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation of fructone catalyzed by aluminum sulfate in ionic liquid medium was written by Lin, Qi;Li, Xinzhong;Chen, Yiting;Lou, Benyong. And the article was included in Journal of Saudi Chemical Society in 2011.Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

Fructone [synthetic aroma, apple ketal 2,4-dimethyl-2-ethylacetoacetate-1,3-dioxolane, 2-methyl-1,3-dioxolane-2-acetic acid Et ester] was prepared from Et acetoacetate (EAA) with 1,2-propanediol (PPO) catalyzed by aluminum sulfate in the presence of an ionic liquid A combination of aluminum sulfate and [bmim]BF₄ exhibited good catalytic activity and high selectivity towards fructone. A synergistic effect of aluminum sulfate and [bmim]BF₄ on the acetalization (ketalization) was observed After the reaction was complete, the products could be separated from the reaction mixture extraction with di-Me ether and the catalyst and ionic liquid could be directly recycled several times without a significant decrease in the activity and selectivity towards fructone. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation and application of magnetic solid acid SO₄^2--/ZrO₂/Fe₃O₄/WO₃ for synthesis of fructone was written by Ren, Bo;Fan, Meiqing;Wang, Jun;Jing, Xiaoyan. And the article was included in Solid State Sciences in 2011.Synthetic Route of C8H14O4 The following contents are mentioned in the article:

A synthesis route to SO₄^2--/ZrO₂/Fe₃O₄/WO₃ solid acid catalysts with magnetism is reported through chem. co-precipitation method. The obtained solid acid catalysts are characterized in detail by x-ray diffraction, Different Scanning Calorimetry (DSC), TEM, Vibrating Sample Magnetometer (VSM), N₂ adsorption-desorption, Temperature-Programmed Pesorption (TPD) of ammonia. The introduction of WO₃ and Fe₃O₄ strongly inhibit the phase transformation of zirconia and improve the thermal stability of zirconia. Furthermore, the obtained materials present super-paramagnetism and magnetism. The super acid exhibits high catalytic activity in forming fructone by condensation. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Synthetic Route of C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Synthetic Route of C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

CycloSal-phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases was written by Spacilova, Pavla;Naus, Petr;Pohl, Radek;Votruba, Ivan;Snasel, Jan;Zabranska, Helena;Pichova, Iva;Ameral, Ria;Birkus, Gabriel;Cihlar, Tomas;Hocek, Michal. And the article was included in ChemMedChem in 2010.Recommanded Product: 158078-04-7 The following contents are mentioned in the article:

A series of cycloSal-phosphate prodrugs of a recently described new class of nucleoside cytostatics (6-hetaryl-7-deazapurine ribonucleosides) was prepared The corresponding 2′,3′-isopropylidene 6-chloro-7-deazapurine nucleosides were converted into 5-O’-cycloSal-phosphates. These underwent a series of Stille or Suzuki cross-couplings with diverse (het)arylstannanes or -boronic acids to yield the protected 6-(het)aryl-7-deazapurine pronucleotides that were subsequently deprotected to give 12 derivatives of free pronucleotides. The in vitro cytostatic effect of the pronucleotides was compared with parent nucleoside analogs. In most cases, the activity of the pronucleotide was similar to or somewhat lower than that of the corresponding parent nucleosides, with the exception of 7-fluoro pronucleotides 13a, 13b, and 13d, which had exhibited GIC₅₀ values that were improved by one order of magnitude (to the low nanomolar range). The presence of a cycloSal-phosphate group also influenced selectivity toward various cell lines. Several pronucleotides were found which strongly inhibit human adenosine kinase but only weakly inhibit the MTB adenosine kinase. This study involved multiple reactions and reactants, such as ((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (cas: 158078-04-7Recommanded Product: 158078-04-7).

((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (cas: 158078-04-7) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 158078-04-7

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A Comparative Human Health Risk Assessment of p-Dichlorobenzene-Based Toilet Rimblock Products Versus Fragrance/Surfactant-Based Alternatives was written by Aronson, Dallas B.;Bosch, Stephen;Gray, D. Anthony;Howard, Philip H.;Guiney, Patrick D.. And the article was included in Journal of Toxicology and Environmental Health in 2007.Synthetic Route of C8H14O4 The following contents are mentioned in the article:

Consumer human health risks from using 1 of 2 types of toilet rimblock products, a p-dichlorobenzene-based rimblock or 2 newer fragrance/surfactant-based alternatives, were assessed. Rimblock products, designed for consumer use worldwide, function by releasing volatile compounds into indoor air with subsequent exposure presumed to be mainly via inhalation. Using the THERdbASE exposure model and exptl. determined emission data, indoor air concentrations and daily intake values were determined for both types of rimblock products. Modeled exposure concentrations from a representative p-dichlorobenzene rimblock product were 1 order of magnitude higher than those from the alternative rimblock products due to its nearly pure composition and high sublimation rate. Lifetime exposure to p-dichlorobenzene or the subset of fragrance components with available reference dose values was not expected to lead to non-cancer-based adverse health effects based on exposure concentrations estimated using the THERdbASE model. A similar comparison of cancer-based effects was not possible since insufficient data were available for the fragrance components. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Synthetic Route of C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of fructone and its derivatives by using acidic ionic liquid as catalyst was written by Yi, Feng-ping;Zhang, Xuan;Pan, Xian-hua;Chen, Shi-hong. And the article was included in Huaxue Shiji in 2011.Quality Control of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

The acid functional ionic liquid 1-(4-sulfobutyl)-3-methylpyrazinium tetrafluoroborate (abbreviated as [4-sulfbmpyrazine][BF₄]), was prepared Fructone and its derivatives I(R¹ = H, Me, R² = MeO, EtO) and II(R = EtO, MeO) were prepared by the reaction of Et acetoacetate and diol in the presence of [4-sulfbmpyrazine][BF₄] as acidic catalyst. And the proper technol. conditions were identified as follows by orthogonal experiments The proper reaction conditions of fructone is a ratio of mol n(Et acetoacetate):n(ethylene glycol) = 0.10:0.15, the reaction time of 6 h, the amount of catalyst of 0.5 g and the amount of cyclohexane as carrying-water reagent of 40 mL. The yield could reach 95.4%. Six kinds of derivatives of fructone are synthesized using acidic functional ionic liquid as catalyst. The catalyst had a fairly high catalytic activity and high yield. The acidic functional ionic liquid could be recovered and reused for at least five times without the loss of efficiency. It provided a new and green way for the synthesis of Fructone and its derivatives This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Quality Control of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Quality Control of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Condensation on the silica-supported cerium (IV) sulfate solid acid catalyst was written by Ren, Liguo;Zhang, Xiaoli;Gao, Wenyi. And the article was included in Xitu in 2012.Reference of 6413-10-1 The following contents are mentioned in the article:

Silica-supported cerium (IV) sulfate [Ce(SO₄)₂/SiO₂] solid acid catalyst was prepared by sol-gel and impregnation methods. The catalytic activities for condensation of Et acetoacetate with 1,3-butandiol were evaluated with the same condition. The effects of the calcination temperature of the catalyst, mass fraction of cerium (IV) sulfate, molar ratio of Et acetoacetate to 1,3-butandiol, mass fraction of Ce(SO₄)₂/SiO₂ and reaction time were discussed in detail. It showed that Ce(SO₄)₂/SiO₂ solid acid was more active than cerium (IV) sulfate tetrahydrate. The yield of fructone was more than 95.5% under the condensation conditions of calcination temperature of catalyst 500 degree, mass fraction of cerium (IV) sulfate 15.0%, molar ratio of Et acetoacetate to 1,3-butandiol 1:1.2, mass fraction of Ce(SO₄)₂/SiO₂ in Et acetoacetate 7.5% and reaction time 120 min. The experiments also revealed that the Ce(SO₄)₂/SiO₂ catalyst had good repetitious and reproducible stability. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Reference of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity was written by Bonday, Zahid Q.;Cortez, Guillermo S.;Grogan, Michael J.;Antonysamy, Stephen;Weichert, Ken;Bocchinfuso, Wayne P.;Li, Fengling;Kennedy, Steven;Li, Binghui;Mader, Mary M.;Arrowsmith, Cheryl H.;Brown, Peter J.;Eram, Mohammad S.;Szewczyk, Magdalena M.;Barsyte-Lovejoy, Dalia;Vedadi, Masoud;Guccione, Ernesto;Campbell, Robert M.. And the article was included in ACS Medicinal Chemistry Letters in 2018.Safety of ((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol The following contents are mentioned in the article:

Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyzes the formation of sym. dimethylarginine in a number of nuclear and cytoplasmic proteins. Although the cellular functions of PRMT5 have not been fully unraveled, it has been implicated in a number of cellular processes like RNA processing, signal transduction and transcriptional regulation. PRMT5 is ubiquitously expressed in most tissues and its expression has been shown to be elevated in several cancers including breast cancer, gastric cancer, glioblastoma and lymphoma. Here we describe the identification and characterization of a novel and selective PRMT5 inhibitor with potent in vitro and in vivo activity. Compound 1 (also called LLY-283) inhibited PRMT5 enzymic activity in vitro and in cells with IC₅₀ of 22 ± 3 nM and 25 ± 1 nM, resp. while its diastereomer, compound 2 (also called LLY-284) was much less active. Compound 1 also showed antitumor activity in mouse xenografts when dosed orally and can serve as an excellent probe mol. for understanding the biol. function of PRMT5 in normal and cancer cells. This study involved multiple reactions and reactants, such as ((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (cas: 158078-04-7Safety of ((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol).

((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (cas: 158078-04-7) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Safety of ((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property was written by Liu, Zhikun;Fang, Lei;Zhang, Huan;Gou, Shaohua;Chen, Li. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

Total sixteen tacrine-curcumin hybrid compounds were designed and synthesized for the purpose of searching for multifunctional anti-Alzheimer agents. In vitro studies showed that these hybrid compounds showed good cholinesterase inhibitory activity. Particularly, the potency of K_3-2 is even beyond tacrine. Some of the compounds exhibited different selectivity on acetylcholinesterase or butyrylcholinesterase due to the structural difference. Thus, the structure and activity relationship is summarized and further discussed based on mol. modeling studies. The ORAC and MTT assays indicated that the hybrid compounds possessed pronounced antioxidant activity and could effectively protect PC12 cells from the H₂O₂/Aβ42-induced toxicity. Moreover, the hybrid compounds also showed pos. metal ions-chelating ability in vitro, suggesting a potential to halt ion-induced Aβ aggregation. All the obtained results demonstrated that the tacrine-curcumin hybrid compounds, in particular compound K_3-2, can be considered as potential therapeutic agents for Alzheimer’s disease. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem