Synthesis and biological activities of new compounds having a 1,3-dioxol[4,5-g]quinoline structure was written by Pellerano, C.;Savini, L.. And the article was included in Farmaco, Edizione Scientifica in 1984.Category: dioxole The following contents are mentioned in the article:
Four substituted 1,3-dioxol[4,5-g]quinolines (I; R = OH, Cl, SH or NHHN2) were prepared by heat cyclization of Et β–(3,4-methylenedioxyphenylamino)crotonate [91918-88-6], followed by substitution of the R groups. By reaction of I (R = NHNH2) with a wide variety of carbonyl compounds, 26 corresponding hydrazones (II) were obtained. All the compounds were tested for antimicrobial activity in vitro and antitumor activity (P388 lymphocytic leukemia) in mice. Most II had good activity against gram-pos. bacteria but not against gram-neg. bacteria, fungi, or Trichomonas vaginalis. I and II were inactive against the tumor. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Category: dioxole).
8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem