Month: November 2022

Wang, Jun-Fei published the artcileSynthesis of Ring A-Modified Baicalein Derivatives, Application of 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, the publication is Helvetica Chimica Acta (2011), 94(12), 2221-2230, database is CAplus.

Baicalein (5,6,7-trihydroxyflavone), an important active constituent of the traditional Chinese herb Scutellaria baicalensis, exhibited antitumor activity and inhibitory activity against P-gp 170. The syntheses of 25 baicalein derivatives are described here. These compounds were systematically modified with O-alkylation and O-acylation at HO-C(5), HO-C(6), and HO-C(7), singly or in combination, on the ring A of baicalein in order to evaluate the effects of such modifications on their inhibitory activities against multidrug-resistant tumor cell lines and P-gp 170 (no data). Highly selective and efficient alkylations at HO-C(7) of peracetylated baicalein were the key to the distinction between HO-C(6) and HO-C(7) of baicalein.

Helvetica Chimica Acta published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C13H11NO, Application of 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Leggetter, B. E. published the artcileThe relative ease of reductive cleavage of 1,3-dioxolanes and 1,3-dioxanes in ether solution by LiAlH₄-AlCl₃, Synthetic Route of 1193-11-9, the publication is Canadian Journal of Chemistry (1964), 42(9), 2113-18, database is CAplus.

In ether solution, 1,3-dioxolanes are hydrogenolyzed faster by LiAlH₄-AlCl₃ than are the corresponding 1,3-dioxanes. This difference is attributed to the relative ease of oxocarbonium ion formation in the rate-determining step of the reaction. The results obtained have been utilized to explain the selective cleavage of the five- and six-membered acetal structures found in the polyacetals of hexitols.

Canadian Journal of Chemistry published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Synthetic Route of 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Curto, John M. published the artcileAsymmetric Synthesis of α-Allyl-α-Aryl α-Amino Acids by Tandem Alkylation/π-Allylation of α-Iminoesters, Synthetic Route of 503538-69-0, the publication is Organic Letters (2014), 16(7), 1948-1951, database is CAplus and MEDLINE.

The first asym. synthesis of α-allyl-α-aryl α-amino acids by means of a three-component coupling of α-iminoesters, Grignard reagents, and cinnamyl acetate is reported. Notably, the enolate from the tandem process provides a much higher level of reactivity and selectivity than the same enolate generated via direct deprotonation, presumably due to differences in the solvation/aggregation state. A novel method for removal of a homoallylic amine protecting group delivers the free amine congeners. The α-allyl group offers a means to generate further valuable α-amino acid structures as exemplified by ring closing metathesis to generate a higher ring homolog of α-aryl-proline.

Organic Letters published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Synthetic Route of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Xu, Ruofei published the artcileExploitation and application of natural edible fungi as cigarette flavor, HPLC of Formula: 1193-11-9, the publication is Jingxi Huagong (2006), 23(11), 1089-1093, database is CAplus.

Three special natural perfumes as cigarette flavor were produced by water distillation, enzyme treating and Maillard reaction from natural edible fungi: Lentinus edodes. The experiments with the perfumes were conducted. The results showed that special fragrant was endowed and smoking and moist quality of cigarette was significantly improved with the cigarette flavor by enzyme treating; both fragrant and sweet of cigarette were improved and smoking was soft with the cigarette flavor by Maillard reaction; and fragrant was improved and awful aftertaste was effectively reduced with the cigarette flavor by water distillation The volatile components in the perfumes were analyzed, and 23, 50 and 38 compounds were identified in the cigarette flavors by water distillation, enzyme treating and Maillard reaction resp.

Jingxi Huagong published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C15H18BF3O2, HPLC of Formula: 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Ibezim, Akachukwu published the artcileBinding of anti-Trypanosoma natural products from African flora against selected drug targets: a docking study, Recommanded Product: 1,4-Dioxaspiro[4.5]decane, the publication is Medicinal Chemistry Research (2017), 26(3), 562-579, database is CAplus.

Recent publications have suggested that African medicinal plants and their derived products could be viable source of new and better trypanocidal drugs. Nowadays, in silico methods are often used in drug discovery processes to identify new potential drug leads. In this study, the authors have developed a small library named Afrotryp, comprising three-dimensional chem. structures of potential trypanocidal compounds derived from medicinal plants in Africa (a total of 321 unique chem. structures). The authors have predicted the pharmacokinetic properties of the library using Qikprop software and employed the three docking/scoring methods implemented in Mol. Operating Environment Dock Tool to assess the affinity of the library dataset towards the binding site of six selected validated anti-Trypanosoma drug targets. It was observed that about 42% of the compounds contained in the Afrotryp dataset were predicted to show a good overall performance in terms of predicted parameters for absorption, distribution, metabolism, elimination and toxicity properties. Docking calculations identified 15 compounds with lowest theor. binding energies toward the studied proteins, nine of which are suited for the treatment of stage 2 human African trypanosomiasis, due to their low polar surface area. Anal. of their binding modes gave basis for the observed unique mol. interactions which exist between the Afrotryp dataset and the six studied drug targets. The results lay the foundations for the rational development of novel trypanocidal drugs with improved potency.

Medicinal Chemistry Research published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Recommanded Product: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Spada, Fernanda Papa published the artcileComprehensive chocolate aroma characterization in beverages containing jackfruit seed flours and cocoa powder, Recommanded Product: 2,2,4-Trimethyl-1,3-dioxolane, the publication is Future Foods (2022), 100158, database is CAplus.

Jackfruit (Artocarpus heterophyllus Lam) occurs abundantly in Brazil, but its seeds are often underutilized in food nutrition. Previously, we showed that roasted jackfruit seeds are an innovative source of chocolate aroma. In this study, we characterized the volatile content of exptl. beverages containing jackfruit seed flours as compared to non-alk. cocoa powder. The three key results of this study were that (i) the fermented jackfruit seed flour beverage (FJSBev) was similar to the non-alk. cocoa powder beverage (CTRLBev); (ii) similar volatile groups (acids, alcs., aldehydes, ester, furans, and pyrazines) were identified in the samples (FJSBev and CTRLBev); (iii) the beverages contained volatile compounds with a low threshold of cocoa attributes (butter, cocoa, coffee, floral, fruit, green, honey, mushroom, nut, and roasted). To conclude, the beverage formulation containing fermented jackfruit seeds had more volatile compounds and odor-active constituents than that with non-alk. cocoa powder. Collectively, our data demonstrate that fermentation is critical to producing a chocolate aroma. Fermented jackfruit seed flours could be used as a partial or total additive to improve chocolate aroma in food formulations.

Future Foods published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C17H28ClNO3, Recommanded Product: 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Hou, Wenqian published the artcileRapidly monitoring the quality of flavoring essence based on microwave-induced plasma ionization mass spectrometry and multivariate statistical analysis, SDS of cas: 1193-11-9, the publication is Talanta (2019), 97-104, database is CAplus and MEDLINE.

Microwave-induced plasma ionization mass spectrometry (MIPI-MS) combined with multivariate statistical anal. was first applied to rapidly monitor the quality of tobacco flavoring essence. A small isolation and reaction chamber was set up between the ion source and the injection port of mass spectrometer to effectively eliminate the interference of external environment in the process of analyzing samples. The improved exptl. apparatus (MIPI-MS) could achieve online and high-throughput anal., with minimal sample preparation steps. Further, two types of tobacco flavoring essences with the similar appearance and physicochem. parameters were employed to verify the usability of the promising method in the field of quality monitoring. Firstly, the mass spectral fingerprint of each essence was established by the improved MIPI-MS method within 2 min. Then, two multivariate statistical processes were carried out to analyze mass spectral data. The similarity results indicated that the thresholds of tobacco flavoring essences from different batches were 1.512 and 2.638, resp. The first three principal components of the established PLS-DA described 93.6% of the total variability, and provided a visualized comparison for the two types of flavoring materials. Finally, the adulterated samples were successfully distinguished by employing the two multivariate statistical processes.

Talanta published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, SDS of cas: 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Seiser, Tobias published the artcileRhodium(I)-Catalyzed 1,4-Silicon Shift of Unactivated Silanes from Aryl to Alkyl: Enantioselective Synthesis of Indanol Derivatives, Computed Properties of 503538-69-0, the publication is Angewandte Chemie, International Edition (2010), 49(52), 10163-10167, S10163/1-S10163/55, database is CAplus and MEDLINE.

Enantioselective Rh-promoted activation and 1,4-positional swap of unactivated tetraorganosilanes, e.g., 1-ethyl-3-methyl-3-(2-(trimethylsilyl)phenyl)cyclobutanol (I) to give (1S,3S)-1-ethyl-3-methyl-3((trimethylsilyl)methyl)indanol (II). E.g., reaction of silylphenyl tert-cyclobutanol I with 2.5 mol% [Rh(cod)OH]₂/6.0 mol% (R)-Difluorphos ligand at 100° in mesitylene gave 82% yield of trans-indanol II (97% ee).

Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C12H17BO4S, Computed Properties of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Climent, Maria Jose published the artcileSynthesis of hyacinth, vanilla, and blossom orange fragrances: the benefit of using zeolites and delaminated zeolites as catalysts, Recommanded Product: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, the publication is Applied Catalysis, A: General (2004), 263(2), 155-161, database is CAplus.

The synthesis of phenylacetaldehyde glycerol acetals, 2-benzyl-4-hydroxymethyl-1,3-dioxolane (1), 2-benzyl-5-hydroxy-1,3-dioxane (2), and vanillin propylene glycol acetal (2-(4-hydroxy-3-methoxyphenyl)-4-methyl-1,3-dioxolane) (3) which are flavoring compounds with hyacinth and vanilla scent fragrances, have been carried out successfully by acetalization of phenylacetaldehyde and vanillin with glycerol and propylene glycol, resp., using toluene as solvent and zeolite catalysts whose adsorption properties have been optimized. However, in the case of a larger size acetal such as 2-acetonaphthone propylene glycol acetal (4) with blossom orange scent, geometrical constraints make the diffusion of reactants and products inside the micropores more difficult. In this case, a delaminated zeolite (ITQ-2) with very large and structured external surface is an active and selective catalyst. Furthermore, the delaminated zeolite allows the reaction to be carried out in a solvent-free system, opening the possibility for an environmentally friendly process for the synthesis of acetal fragrances.

Applied Catalysis, A: General published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, Recommanded Product: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Lin, Junzhong published the artcileHierarchical Shell-Like ZSM-5 with Tunable Porosity Synthesized by using a Dissolution-Recrystallization Approach, Quality Control of 177-10-6, the publication is Chemistry – A European Journal (2018), 24(56), 14974-14981, database is CAplus and MEDLINE.

Zeolites have been widely used in various fields in industry, such as catalysis, separation, and adsorption, etc. The small pore size of the micropores in the zeolite could lead to severe diffusion resistance in mass transfer. Numerous efforts have been dedicated to imposing hierarchical pore systems into zeolites by using templates or leaching methods. Here, we report the synthesis of single-crystalline hierarchical shell-like ZSM-5 by utilizing a dissolution-recrystallization post-treatment on mesoporous ZSM-5. Tetrapropylammonium hydroxide solution was used in the post-treatment. The hierarchical porosity in the crystalline shell can be controlled by adding sodium cations into the synthesis system. The hierarchical shell-like ZSM-5 reported here shows higher catalytic activity in acetalization reactions containing bulky mols.

Chemistry – A European Journal published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Quality Control of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem