Category: Dioxole

Essential Oil of Deverra tortuosa Aerial Parts: Detailed Chemical Profile, Allelopathic, Antimicrobial, and Antioxidant Activities was written by Fayed, Eman M.;Abd-EIGawad, Ahmed M.;Elshamy, Abdelsamed I.;El-Halawany, El-Sayed F.;EI-Amier, Yasser A.. And the article was included in Chemistry & Biodiversity in 2021.Synthetic Route of C11H12O3 This article mentions the following:

Essential oils (EOs) are a promising group of natural products of the aromatic plants due to their various biol. effects such as allelopathic, antioxidant, antimicrobial activities. The present study aimed to construct the detailed chem. profile of the EO derived from Deverra tortuosa aerial parts along with assessing its allelopathic, antimicrobial, and antioxidant potentialities. The EO was extracted by hydrodistillation and analyzed via gas chromatog.-mass spectrometry (GC/MS). The allelopathic activity of the EO was assessed against the germination and seedling growth of the weed Chenopodium murale. Also, the EO was tested against five microbes. The antioxidant activity was determined using the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). The GC/MS anal. of EO revealed the presence of 86 compounds with a preponderance of oxygenated sesquiterpenes and monoterpene hydrocarbons. Widdrol, β-phellandrene, piperitol, cubedol, α-terpinene, (E)-10-heptadecen-8-ynoic acid Me ester, citronellyl tiglate, and m-cymene were the major compounds A comparative profile was established between the EOs constituents of our study with the documented EOs of D. tortuosa and the other Deverra species around the world via agglomerative hierarchical clustering (AHC) and principal components anal. (PCA). The EO showed a substantial allelopathic activity against C. murale, as well as it showed considerable antimicrobial and antioxidant activities. Thereby, the EO of D. tortuosa could be considered as a promising environmental-friendly bioherbicide against weeds. Also, it could be integrated into food preservation due to its potent antimicrobial and antioxidant activities. However, further study is recommended for more characterization of the major compounds and evaluation of their activities, either singular or synergistic, and assess their efficiency and biosafety. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Synthetic Route of C11H12O3).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Synthetic Route of C11H12O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of vanillin 1,2-propylene glycol acetal catalyzed by H₃PMo₁₂O₄₀ was written by Jiang, Wei-hua;Meng, Qi;Xi, Hai-tao;Jiang, Yan;Sun, Xiao-qiang. And the article was included in Huaxue Shiji in 2009.SDS of cas: 68527-74-2 This article mentions the following:

A method for the synthesis of the title compound [i.e., 2-methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, vanillin 1,2-propylene glycol acetal] is reported here. Vanillin 1,2-propylene glycol acetal was synthesized from vanillin [i.e., 4-hydroxy-3-methoxybenzaldehyde] and 1,2-propylene glycol using H₃PMo₁₂O₄₀ as the catalyst. Factors influencing the product formation, such as molar ratio of reactants, time, catalyst type and amount, and different water entrainment agents, were studied and optimized reaction conditions were determined Reaction conditions were found as follows: molar ratio of aldehyde/glycol = 1.0/1.3, catalyst dosage of 0.3%, a cyclohexane amount of 15 mL, and a reaction time of 4.5 h. The selectivity was above 98% and the product yield was 94.58%. The product structure was determined by IR, GC, NMR. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2SDS of cas: 68527-74-2).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 68527-74-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Effect of polymer matrices of gels bearing a sulfo group on their catalytic properties for acetalization of glycerol to solketal and esterification of oleic acid to ethyl oleate was written by Tokuyama, Hideaki;Ohno, Hiroki;Fujita, Tara. And the article was included in Reactive & Functional Polymers in 2021.Product Details of 100-79-8 This article mentions the following:

A novel type of copolymer gel bearing the sulfo group was developed as a heterogeneous acid catalyst for the solvent free acetalization of glycerol with acetone to form a desirable solketal, as well as the solvent free esterification of oleic acid with ethanol to form Et oleate as a biodiesel fuel. The copolymer gels were synthesized by the copolymerization of a primary monomer (ethoxy diethyleneglycol acrylate (EDGA), N-isopropylacrylamide (NIPA), etc.) with 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS). The copolymer gels, such as EDGA-co-AMPS gel and NIPA-co-AMPS gel, successfully catalyzed both reactions with a higher reaction rate than those of AMPS gel and the conventional sulfonic ion exchange resin (Amberlyst). According to Le Chatelier’s principle, if a gel catalyst absorbs reactants well, and expels or poorly absorbs products, the apparent rate of the reaction occurring within the gel is enhanced. This hypothesis was examined by analyzing the solution absorptions of these gels and their reaction rates, including Eley-Rideal kinetic anal. In the experiment, the researchers used many compounds, for example, (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8Product Details of 100-79-8).

(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Product Details of 100-79-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Antitumor Agents. 211. Fluorinated 2-Phenyl-4-quinolone Derivatives as Antimitotic Antitumor Agents was written by Xia, Yi;Yang, Zheng-Yu;Xia, Peng;Hackl, Torben;Hamel, Ernest;Mauger, Anthony;Wu, Jiu-Hong;Lee, Kuo-Hsiung. And the article was included in Journal of Medicinal Chemistry in 2001.HPLC of Formula: 28657-75-2 This article mentions the following:

Fluorinated 2-phenyl-4-quinolone derivatives were synthesized and evaluated in National Cancer Institute’s 60 human tumor cell line in vitro screen. From the results, the ketone moiety plays an essential role in activity. Among the compounds tested, 2-(2-fluorophenyl)-6-pyrrol-1-yl-4-quinolone (I) exhibited the most potent cytotoxic activities (log GI₅₀ < -8.00) against renal and melanoma tumor cell lines. I was also a potent inhibitor of tubulin polymerization (IC₅₀ = 0.46 μM) and of radiolabeled colchicine binding to tubulin, with activities comparable to those of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2HPLC of Formula: 28657-75-2).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.HPLC of Formula: 28657-75-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Hydroxyl-Functionalized Imidazoles: Highly Active Additives for the Potassium Iodide-Catalyzed Synthesis of 1,3-Dioxolan-2-one Derivatives from Epoxides and Carbon Dioxide was written by Werner, Thomas;Tenhumberg, Nils;Buettner, Hendrik. And the article was included in ChemCatChem in 2014.Application of 13818-44-5 This article mentions the following:

4(5)-(Hydroxymethyl)imidazole and potassium iodide were identified as an efficient catalyst system for the cycloaddition of epoxides, e.g., 1,2-butylene oxide, and carbon dioxide producing 1,3-dioxolan-2-one derivatives, e.g., 4-ethyl-1,3-dioxolan-2-one, under solvent-free conditions. The high activity of the catalyst system even at 60 °C was probably due to synergistic effects between potassium iodide and the substituted imidazole. Various functionalized and nonfunctionalized terminal epoxides as well as internal epoxides were converted into the corresponding cyclic carbonates in high yields (up to 99 %) under mild reaction conditions within a short reaction time. Compared with the previously reported amino alcs., e.g. triethanolamine based catalyzed synthesis of cyclic carbonates, the catalyst system described herein demonstrates a higher activity toward a broad substrate scope. In the experiment, the researchers used many compounds, for example, (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5Application of 13818-44-5).

(2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 13818-44-5

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Chiral Aluminum Complex Controls Enantioselective Nickel-Catalyzed Synthesis of Indenes: C-CN Bond Activation was written by Zhang, Tao;Luan, Yu-Xin;Zheng, Su-Juan;Peng, Qian;Ye, Mengchun. And the article was included in Angewandte Chemie, International Edition in 2020.Synthetic Route of C47H38O4 This article mentions the following:

A chiral aluminum complex controlled, enantioselective nickel-catalyzed domino reaction of aryl nitriles and alkynes proceeding by C-CN bond activation was developed. The reaction provides various indenes, bearing chiral all-carbon quaternary centers, under mild reaction conditions in yields of 32 to 91% and ee values within the 73-98% range. The reaction mechanism and aspects of stereocontrol were investigated by DFT calculations Thus, e.g., domino C-CN bond activation/insertion reaction of nitrile I with 4-octyne in presence of Ni(cod)₂, tris(4-methoxyphenyl)phosphine, a chiral TADDOL and Al(iBu)₃ afforded indene II (86%, 92% ee). In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol) (cas: 171086-52-5Synthetic Route of C47H38O4).

((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol) (cas: 171086-52-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Synthetic Route of C47H38O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of vanillin propylene glycol acetal over different molecular sieve catalysts was written by Wang, Wen-lan;Huang, Yong;Meng, Qing-lei;Liu, Bai-jun. And the article was included in Huaxue Gongchengshi in 2009.Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol This article mentions the following:

The vanillin 1,2-propylene glycol acetal was synthesized using vanillin and 1,2-propylene glycol as starting materials and HZSM-5, HY, H beta, HMCM-22, HMCM-41 different type mol. sieve as the catalyst. The catalysts were characterized by means of N₂ adsorption-desorption and FT-IR of adsorption pyridine. The results indicate that the HMCM-22 mol. sieve has the higher activity and the each kind of mol. sieve active order is: HMCM-22 > H beta > USY > HY > HZSM-5 > HMCM-41. The higher activity was due to the large secondary pore structure of HMCM-22 mol. sieve and the suitable acidity. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic effect of crown ethers in the bromination of 2-alkyl-1,3-dioxacyclanes was written by Kotlyar, S. A.;Pluzhnik-Gladyr, S. M.. And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) in 1998.Product Details of 4360-63-8 This article mentions the following:

Bromination of 2-alkyl-1,3-dioxacyclanes (I; R = H, Me; n = 0, 1, 2) with mol. bromine in the presence of crown ethers in benzene (chloroform) results, regardless of the acetal ring size, in exclusive formation of II (same R, n) in nearly quant. yields. The use of crown ethers allows the bromination to be accomplished at room temperature In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Product Details of 4360-63-8).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 4360-63-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The chemical and metabolite profiles of Gualou-Xiebai-Banxia decoction, a classical traditional Chinese medicine formula, by using high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and in-house software was written by Xiang, Zheng;Wang, Yuzhen;Liu, Shundi. And the article was included in Journal of Ethnopharmacology in 2022.Category: dioxole This article mentions the following:

Gualou-Xiebai-Banxia decoction (GXBD) was a classical traditional Chinese medicine formula for the treatment of coronary heart disease. However, the current study on the chem. and metabolite profiles of GXBD did not follow the ancient prescription and extraction method, which hindered the discovery of effective compounds and quality control. In this study, we prepared GXBD by ancient prescription and extraction methods, and then analyzed the chem. components and xenobiotics of GXBD in vivo using high-performance liquid chromatog. coupled with quadrupole time-of-flight mass spectrometry and inhouse software.49 chem. constituents were preliminarily identified, including 7 terpenoids, 6 flavonoids, 5 alkaloids, 17 organic acids, 8 steroids and steroidal saponins, 2 nucleosides and 4 other types of compounds, of which 10 constituents were confirmed unambiguously with authentic standards Moreover, 129 metabolites were tentatively identified, including 83 metabolites in plasma, 39 metabolites in urine, 25 metabolites in bile and 9 metabolites in feces. Our study speculated that luteolin, adenosine, vanillic acid and curbitacin B might be possible effective components of GXBD for the treatment of coronary heart disease. Dehydration, deglycosylation, dehydrogenation, acetylation and taurine regulation were the main biotransformation reactions of GXBD. Our results provided an important basis for the discovery of effective compounds and quality control of GXBD. In addition, inhouse software was an useful tool for identifcation of metabolites. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Category: dioxole).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Stereoselective Hydrosilylation of Enals and Enones Catalysed by Palladium Nanoparticles was written by Benohoud, Meryem;Tuokko, Sakari;Pihko, Petri M.. And the article was included in Chemistry – A European Journal in 2011.Product Details of 177-10-6 This article mentions the following:

A highly versatile and efficient hydrosilylation method by palladium nanoparticle catalysis allows the direct and chemoselective synthesis of enolsilanes, e.g. I (R = Bn, t-Bu, Boc-N), of high isomeric purity, saturated aldehydes or ketones, e.g. 2-methyl-3-phenylpropanal and 2-nonanone, or the corresponding saturated acetals, e.g. II, from α,β-unsaturated aldehydes or ketones. The choice of the product is determined by simply switching the solvent from THF to mixtures of THF/water or THF/alc. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Product Details of 177-10-6).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 177-10-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem