Category: Dioxole

Lu, Ting et al. published their research in Journal of Solid State Chemistry in 2017 | CAS: 177-10-6

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C8H14O2

Four Strandberg-type polyoxometalates with organophosphine centre decorated by transition metal-2,2′-bipy/H2O complexes was written by Lu, Ting;Feng, Shu-Li;Zhu, Zai-Ming;Sang, Xiao-Jing;Su, Fang;Zhang, Lan-Cui. And the article was included in Journal of Solid State Chemistry in 2017.Formula: C8H14O2 This article mentions the following:

Four inorganic-organic hybrid compounds composed of Strandberg-type organophosphomolybdate anion [(C6H5PO3)2Mo5O15]4- (abbreviated as (PhP)2Mo5) and transition metal (TM)-2,2′-bipy/H2O complex units, namely [(TM(H2O)(bipy))2(C6H5PO3)2Mo5O15]n (TM = Co, (1); Ni, (2)), [(Cu(bipy)2)2(C6H5PO3)2Mo5O15]·2H2O (3) and [(Zn(bipy)(μ-OH))2(Zn(bipy)2(C6H5PO3)2Mo5O15)2]·3H2O (4) (bipy = 2,2′-bipyridine), were successfully constructed under hydrothermal conditions, and their structures were determined by single crystal x-ray diffraction anal. and spectroscopic methods. The central heteroatoms in these polyoxometalates (POMs) are all organophosphine (RP) groups. Compound 1 and compound 2 are isostructural (PhP)2Mo5-based TM-coordination polymers with the two-dimensional layer frameworks. In compound 3, the bi-supporting structure containing one (PhP)2Mo5 unit and two [Cu(bipy)2]2+ cations. For compound 4, it can be regarded as a dimer of two bi-supporting {Zn(bipy)2(PhP)2Mo5Zn(bipy)} clusters that were connected by two μ-OH groups. The acid-catalytic activities and fluorescence properties of the four hybrids have been investigated. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Formula: C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Krishna, Thalishetti et al. published their research in ChemistrySelect in 2019 | CAS: 15186-48-8

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.COA of Formula: C6H10O3

Copper-Catalyzed One-Pot Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives from 1-(2-Aminophenyl)-pyrroles and Aldehydes was written by Krishna, Thalishetti;Reddy, Thatikonda Narendar;Laxminarayana, Eppakayala;Kalita, Dipak. And the article was included in ChemistrySelect in 2019.COA of Formula: C6H10O3 This article mentions the following:

A facile and highly efficient copper-catalyzed strategy has been developed for the synthesis of pyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)-pyrroles and aldehydes at room temperature This reaction proceeds via imine formation, cyclisation, and oxidation in one-pot. This strategy provides a facile and rapid access to pyrrolo[1,2-a]quinoxalines in good to high yields under mild conditions. This process has several advantages, such as simple reaction procedure, readily available starting materials, low catalyst loading, easy product isolation, broad substrate scope, high functional group tolerance, and gram-scale synthesis. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8COA of Formula: C6H10O3).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.COA of Formula: C6H10O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Liu, Taotao et al. published their research in RSC Advances in 2014 | CAS: 177-10-6

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 1,4-Dioxaspiro[4.5]decane

Zeolite nanofiber assemblies as acid catalysts with high activity for the acetalization of carbonyl compounds with alcohols was written by Liu, Taotao;Fu, Wenqian;Zheng, Xiang;Jiang, Jun;Hu, Maolin;Tang, Tiandi. And the article was included in RSC Advances in 2014.Recommanded Product: 1,4-Dioxaspiro[4.5]decane This article mentions the following:

Zeolite nanofiber assemblies (HNB-MOR) as efficient heterogeneous catalysts for the formation of a range of acetals in good yields. The mesoporosity of HNB-MOR benefits mass transfer, and the strong acidic sites on HNB-MOR facilitate acetalization activity. The catalyst can be reused 10 times without loss of activity. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Recommanded Product: 1,4-Dioxaspiro[4.5]decane).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 1,4-Dioxaspiro[4.5]decane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Chen, Zhi-sheng et al. published their research in Guangzhou Huagong in 2011 | CAS: 177-10-6

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C8H14O2

The synthesis of cyclohexanone ethylene ketal catalyzed by solid superacid S2O82-/SnO2-SiO2 catalyst was written by Chen, Zhi-sheng;Guo, Hai-fu;Yan, Peng;Wang, Zhao-zhi. And the article was included in Guangzhou Huagong in 2011.Computed Properties of C8H14O2 This article mentions the following:

Cyclohexanone ethylene ketal was synthesized from cyclohexanone and ethylene glycol in the presence of solid S2O82-/SnO2-SiO2. The effect of molar ratio of cyclohexanone to ethylene glycol, catalyst amount, reaction time, and amount of the water-entraining agent on the ketalization reaction were investigated. The optimum conditions were that molar ratio of cyclohexanone to ethylene glycol was 1:1.5, cyclohexane as water-entraining agent, the quantity of catalyst was equal to 0.5% of feed stocks, and the reaction time was 1.5 h. S2O82-/SnO2-SiO2 was a good catalyst for synthesizing cyclohexanone ethylene ketal and its yield can reach 86.9%. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Computed Properties of C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Kumar, Sanjeev et al. published their research in European Journal of Medicinal Chemistry in 2020 | CAS: 100-79-8

(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C6H12O3

Discovery of indoximod prodrugs and characterization of clinical candidate NLG802 was written by Kumar, Sanjeev;Jaipuri, Firoz A.;Waldo, Jesse P.;Potturi, Hima;Marcinowicz, Agnieszka;Adams, James;Van Allen, Clarissa;Zhuang, Hong;Vahanian, Nicholas;Link, Charles Jr.;Brincks, Erik L.;Mautino, Mario R.. And the article was included in European Journal of Medicinal Chemistry in 2020.Synthetic Route of C6H12O3 This article mentions the following:

A series of different prodrugs of indoximod, including esters and peptide amides were synthesized with the aim of improving its oral bioavailability in humans. The pharmacokinetics of prodrugs that were stable in buffers, plasma and simulated gastric and intestinal fluids was first assessed in rats after oral dosing in solution or in capsule formulation. Two prodrugs that produced the highest exposure to indoximod in rats were further tested in Cynomolgus monkeys, a species in which indoximod has oral bioavailability of 6-10% and an equivalent dose-dependent exposure profile as humans. NLG802 was selected as the clin. development candidate after increasing oral bioavailability (>5-fold), Cmax (6.1-3.6 fold) and AUC (2.9-5.2 fold) in monkeys, compared to equivalent molar oral doses of indoximod. NLG802 is extensively absorbed and rapidly metabolized to indoximod in all species tested and shows a safe toxicol. profile at the anticipated therapeutic doses. NLG802 markedly enhanced the anti-tumor responses of tumor-specific pmel-1 T cells in a melanoma tumor model. In conclusion, NLG802 is a prodrug of indoximod expected to increase clin. drug exposure to indoximod above the current achievable levels, thus increasing the possibility of therapeutic effects in a larger fraction of the target patient population. In the experiment, the researchers used many compounds, for example, (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8Synthetic Route of C6H12O3).

(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C6H12O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Liu, Zhaoyu et al. published their research in Yingyong Huaxue in 2015 | CAS: 177-10-6

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Quality Control of 1,4-Dioxaspiro[4.5]decane

Synthesis and catalytic activity of a Strandberg-type molybdophosphate modified by organic cations was written by Liu, Zhaoyu;Zhu, Haotian;Lu, Mingda;Li, Xiaohui;An, Yue;Zhang, Lancui. And the article was included in Yingyong Huaxue in 2015.Quality Control of 1,4-Dioxaspiro[4.5]decane This article mentions the following:

A Strandberg-type molybdophosphate {H4(H2biim)5(C(NH2)3)4} [H2P2Mo5O23]2 · 8H2O (1, H2biim = 2,2′-biimidazole) modified by 2,2′-biimidazole and guanidinium cations was self-assembled in aqueous solution of pH = 3-4 containing sodium molybdate, 2,2′-biimidazole, guanidine hydrochloride and an excess of phosphoric acid, and was characterized by single crystal X-ray diffraction anal., IR spectroscopy (FT-IR), themogravimetry-DTA (TG-DTA) and X-ray powder diffraction (XRD). Compound 1 has a stable 3D organic-inorganic hybrid framework. It was used as a catalyst for carbonyl-protection. The synthesis of cyclohexanone ethylene ketal was performed as an example to investigate some influence factors on the yield, such as catalyst loading, molar ratio of reactants and reaction time. The optimal conditions are: the molar ratio of catalyst (based on Mo) to ketone is 1:300, the molar ratio of ketone to alc. is 1:1.4, and reaction time is 2.5 h. The catalytic activity of compound 1 for the synthesis of four other ketals was evaluated. The results show that compound 1 is a better catalyst for the synthesis of cyclohexanone ethylene ketal. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Quality Control of 1,4-Dioxaspiro[4.5]decane).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Quality Control of 1,4-Dioxaspiro[4.5]decane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Li, Leping et al. published their research in Journal of Medicinal Chemistry in 1994 | CAS: 28657-75-2

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Reference of 28657-75-2

Antitumor Agents 155. Synthesis and Biological Evaluation of 3′,6,7-Substituted 2-Phenyl-4-quinolones as Antimicrotubule Agents was written by Li, Leping;Wang, Hui-Kang;Kuo, Sheng-Chu;Wu, Tian-Shung;Mauger, Anthony;Lin, Chii M.;Hamel, Ernest;Lee, Kuo-Hsiung. And the article was included in Journal of Medicinal Chemistry in 1994.Reference of 28657-75-2 This article mentions the following:

A series of 3′,6,7-substituted 2-phenyl-4-quinolones were designed and synthesized as antimitotic antitumor agents. All compounds showed cytotoxic effects (log GI50 ≤ -4.0; log drug molar concentration required to cause 50% inhibition) against the growth of a variety of human tumor cell lines, including those derived from solid tumors such as non-small cell lung, colon, central nervous system, ovary, prostate, and breast cancers, when evaluated in the National Cancer Institute’s 60 human tumor cell line in vitro screen. The most potent compound (I) demonstrated strong cytotoxic effects with GI50 values in the nanomolar or subnanomolar range in almost all the tumor cell lines. Compound I was also a potent inhibitor of tubulin polymerization and radiolabeled colchicine binding to tubulin, with activity comparable to those of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Reference of 28657-75-2).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Reference of 28657-75-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Huang, Yixuan et al. published their research in ACS Omega in 2021 | CAS: 100-79-8

(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Electric Literature of C6H12O3

Preparation of the WOX/MCM-41 Solid Acid Catalyst and the Catalytic Performance for Solketal Synthesis was written by Huang, Yixuan;Zhang, Guangcai;Zhang, Qinhui. And the article was included in ACS Omega in 2021.Electric Literature of C6H12O3 This article mentions the following:

In the present work, an efficient and stable WOX/MCM-41 solid acid catalyst was prepared by the wet impregnation method. The characterization of powder X-ray diffraction, transmission electron microscopy, UV-visible, H2 temperature-programmed reduction, XPS, NH3 temperature-programmed desorption, and N2 adsorption-desorption isotherms confirmed that the impregnation amount and calcination temperature of WOX speciation affected the dispersity and acidity of the resulting catalyst. This WOX/MCM-41 solid acid catalyst was subsequently applied in the ketalization reaction of glycerol and acetone to produce solketal. By catalyst screening and reaction condition optimization, WOX/MCM-41 obtained by impregnating 20 weight % and calcining at 350°C exhibited the highest solketal yield and catalytic stability. In the experiment, the researchers used many compounds, for example, (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8Electric Literature of C6H12O3).

(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Electric Literature of C6H12O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Pinho, Pedro et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2017 | CAS: 15186-48-8

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Discovery of β-D-2′-deoxy-2′-dichlorouridine nucleotide prodrugs as potent inhibitors of hepatitis C virus replication was written by Pinho, Pedro;Kalayanov, Genadiy;Westerlind, Hans;Rosenquist, Aasa;Waehling, Horst;Sund, Christian;Almeida, Maria;Ayesa, Susana;Tejbrant, Jan;Targett-Adams, Paul;Eneroth, Anders;Lindqvist, Annelie. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Category: dioxole This article mentions the following:

Discovery of sofosbuvir has radically changed hepatitis C treatment and nucleoside/tide NS5B inhibitors are now viewed as one of the key components in combination therapies with other direct-acting antiviral agents. As part of our program to identify new nucleoside inhibitors of HCV replication, we now wish to report on the discovery of β-D-2′-deoxy-2′-dichlorouridine nucleotide prodrugs as potent inhibitors of HCV replication. Although, cytidine analogs have long been recognized to be metabolized to both cytidine and uridine triphosphates through the action of cytidine deaminase, uridine analogs are generally believed to produce exclusively uridine triphosphate. Detailed investigation of the intracellular metabolism of our newly discovered uridine prodrugs, as well as of sofosbuvir, has now revealed the formation of both uridine and cytidine triphosphates. This occurs, not only in vitro in cell lines, but also in vivo upon oral dosing to dogs. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8Category: dioxole).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Liu, Chun-Sheng et al. published their research in Polymer-Plastics Technology and Engineering in 2009 | CAS: 126-39-6

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C6H12O2

I2-doped chitosan: an easily recoverable and efficient catalyst for acetalization of carbonyl compounds with diols was written by Liu, Chun-Sheng;Luo, Gen-Xiang. And the article was included in Polymer-Plastics Technology and Engineering in 2009.Computed Properties of C6H12O2 This article mentions the following:

Chitosan-I2 is prepared by doping of chitosan with iodine (I2). Chitosan-I2 are characterized by phys. and spectral methods. Chitosan-I2 is used as catalyst for the first time in acetalization of carbonyl compounds The catalyzed acetalization of benzaldehyde and glycol is conducted in excellent yields with simple and more environmental benign procedure. The use of chitosan-I2 catalyst is feasible because of its easy preparation, easy handling, stability, easy recovery, reusability, good activity and eco-friendly. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Computed Properties of C6H12O2).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C6H12O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem