Antitumor Agents. 211. Fluorinated 2-Phenyl-4-quinolone Derivatives as Antimitotic Antitumor Agents was written by Xia, Yi;Yang, Zheng-Yu;Xia, Peng;Hackl, Torben;Hamel, Ernest;Mauger, Anthony;Wu, Jiu-Hong;Lee, Kuo-Hsiung. And the article was included in Journal of Medicinal Chemistry in 2001.HPLC of Formula: 28657-75-2 This article mentions the following:
Fluorinated 2-phenyl-4-quinolone derivatives were synthesized and evaluated in National Cancer Institute’s 60 human tumor cell line in vitro screen. From the results, the ketone moiety plays an essential role in activity. Among the compounds tested, 2-(2-fluorophenyl)-6-pyrrol-1-yl-4-quinolone (I) exhibited the most potent cytotoxic activities (log GI50 < -8.00) against renal and melanoma tumor cell lines. I was also a potent inhibitor of tubulin polymerization (IC50 = 0.46 μM) and of radiolabeled colchicine binding to tubulin, with activities comparable to those of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2HPLC of Formula: 28657-75-2).
1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.HPLC of Formula: 28657-75-2
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem