Category: Dioxole

Catalytic synthesis of butanone glycol ketal with strong acid cation-exchange resin was written by Liu, Chun-ling;Liu, He-qun;Gao, Wen-xiu. And the article was included in Huaxue Gongchengshi in 2007.Electric Literature of C6H12O2 This article mentions the following:

Butanone glycol ketal (i.e., 2-ethyl-2-methyl-1,3-dioxolane) was prepared by a reaction of butanone with glycol in the presence of a strongly acidic cation-exchange resin. The cation exchange resin’s catalytic activity to the ketal reaction was discussed. The factors influencing the product yield, such as molar ratio of ketone and alc., catalyst quantity and reaction time were systematically studied. The experiments showed that such a strong-acid cation-exchange resin is a good catalyst to synthesis of butanone glycol ketal. The yield of butanone glycol ketal reach 76.5% under the following optimum conditions: n(butanone) : (glycol) = 1:2, catalyst quantity is equal to 0.5% by mass of the total reaction materials, cyclohexane is used as water entrainment agent, the reaction time is 3h. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Electric Literature of C6H12O2).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Electric Literature of C6H12O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Application of growth promoting hormones alters the composition and antioxidant potential of dill essential oil under salt stress was written by Ghassemi-Golezani, Kazem;Nikpour-Rashidabad, Neda;Samea-Andabjadid, Samira. And the article was included in Scientific Reports in 2022.SDS of cas: 607-91-0 This article mentions the following:

The performance of dill plant may be affected by adverse environments such as salinity. Thus, this research was designed to evaluate changes in chem. composition and antioxidant activity of seed essential oil of dill (Anethum graveolens L.) in response to salinity (0, 5, 10 and 15 dS/m) and 1 mM of each hormonal treatments (gibberellic acid, salicylic acid, and cytokinin). Salicylic acid (SA) reduced Na+ content of roots and leaves by 15.4%, 30.9% and 12.4%, 24.3%, but enhanced K+ content by 29.8%, 51.6% and 76.6%, 73.4% under moderate and severe salinities, resp. Essential oil yield was enhanced with progressing seed filling, despite decreasing essential oil percentage. Percentage of essential oil was increased under low and moderate salinities. Hormonal treatments, particularly SA enhanced seed mass and essential oil percentage, leading to enhanced essential oil yield. The amounts of most constituents were enhanced under moderate salinity. Foliar spray of SA and CK (cytokinin) increased almost all essential oil components, except dill ether and dill apiole, while the GA3 (gibberellic acid) treatment reduced most of the constituents. The α-fenchol was only induced by salt stress. The β-pinene, 1-terpineol, cryptone, oxypeucedanin hydrate, α-thujene and P-α-dimethylstyrene were also specifically synthesized in SA treated plants under salinity. The highest TPC (total phenolic content) and antioxidant activity were recorded for essential oil of SA treated plants at mass maturity under moderate salinity. In general, the SA spray was the most effective treatment for improving essential oil quantity and quality of dill plants. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0SDS of cas: 607-91-0).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 607-91-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and properties of O-glycosyl calix[4]arenes (calixsugars) was written by Dondoni, Alessandro;Marra, Alberto;Scherrmann, Marie-Christine;Casnati, Alessandro;Sansone, Francesco;Ungaro, Rocco. And the article was included in Chemistry – A European Journal in 1997.Recommanded Product: 14131-84-1 This article mentions the following:

Model O-glycosylation reactions at either rim of calix[4]arenes are described with the aim of providing access to a new family of carbohydrate-containing calixarene derivatives named calixsugars. One or two sugar moieties (D-mannofuranose and D-glucopyranose) were introduced at the lower rim of the parent calix[4]arene by glycosylation of the phenolic hydroxyl groups by means of a Mitsunobu reaction. Tetrapropoxy calix[4]-arenes bearing two or four hydroxymethyl groups at the upper rim were coupled with perbenzoylated thioethyl D-galactoside and D-lactoside in the presence of the thiophilic promoter copper(II) triflate. In this way β-linked bis- and tetrakis-O-galactosyl calix[4]arenes were obtained in good yield, the latter showing some solubility in water. For the O-lactosyl derivatives only the bis-substituted compound could be obtained because of the competing formation of an intramol. ether linkage between 1,3-hydroxymethyl groups. Preliminary binding studies showed some affinity of the galactose-containing calixsugars toward charged carbohydrates and dihydrogen phosphate anion. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Recommanded Product: 14131-84-1).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 14131-84-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Derivatives of cyclic acetals. I. Cyclic chloro acetals and their derivatives was written by Yasnitskii, B. G.;Sarkisyants, S. A.;Ivanyuk, E. G.. And the article was included in Zhurnal Obshchei Khimii in 1964.COA of Formula: C4H7ClO2 This article mentions the following:

The sulfonated polystyrene ion-exchange resin (KU-1) was found to be an effective agent for formation of cyclic acetals of ClCH₂CHO. Thus, heating 1 kg. 98% glycerol with 475 g. (ClCH₂CHO)_2.H₂O and 28 g. KU-1 resin 10-12 h. at 80-90° gave 96% glycerol α,β-chloroacetal, b₉ 125-30°. Similarly were prepared 60-86% cyclic acetals of ClCH₂CHO and ethylene glycol (I), propylene glycol, α-chloroglycerol (II), diethylene glycol, pentaerythritol, mannitol, and sorbitol. The cyclic acetal (IIa) of ClCH₂CHO and I added slowly to tert-BuOK in tert-BuOH and then heated 2 h. at 80-5° gave 85% III, b₉ 56-7°, d₂₀ 1.0096, n²⁰_D 1.4350. Similarly were prepared 52% IV, b. 127-8°, -, 1.4465 (at 25°); 75.2% V, b. 169-70°, 1.2346, 1.4530; and 40% VI, m. 52°. To 25 g. K in 500 g. BuOH was added 78.3 g. IIa (b₉ 52-3°, 1.2475, 1.4474) and the mixture kept 10-12 h. at 110-20° to give 62.5% VII, b₅ 47-9°, 0.9892, 1.4225, also formed from III and KOH in BuOH. Similarly was prepared 85% the ethoxy analog. The acetals based on ketene readily formed glassy polymers. The following constants were given for the cyclic chloroacetals (alc., b.p., d₂₀, and n²⁰_D given): glycerol, b₀ 125-30°, 1.3245, 1.475; propylene glycol, b₅ 45-6°, 1.1597, 1.4420; α-chloroglycerol, b₄ 82-3°, 1.3498, 1.4750; diethylene glycol, b₅ 115-18° (m. 45-6°), 1.1670, 1.4562; pentaerythritol, – (m. 92°), -, -; mannitol, b_·1-0.2 195-200°, 1.4473, 1.5048; sorbitol, b_0.05 219-20°, 1.4484, 1.5096. In the experiment, the researchers used many compounds, for example, 2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1COA of Formula: C4H7ClO2).

2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.COA of Formula: C4H7ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthetic study of marine diterpenoid aberrarone: stereocontrolled construction of tetracyclic framework was written by Kobayashi, Toyoharu;Tokumoto, Kasumi;Tsuchitani, Yuki;Abe, Hideki;Ito, Hisanaka. And the article was included in Tetrahedron in 2015.Recommanded Product: 2-Bromomethyl-1,3-dioxolane This article mentions the following:

Highly stereocontrolled synthesis of the tetracyclic framework of the marine diterpenoid aberrarone (I), which possesses antimalarial activity against a chloroquine-resistant strain of Plasmodium, has been accomplished. A key feature of the synthesis is the complete stereocontrolled construction of C- and D-ring using stereoselective 1,4-addition followed by intramol. aldol reaction protocol. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Recommanded Product: 2-Bromomethyl-1,3-dioxolane).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 2-Bromomethyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Ni-Al Bimetallic Catalyzed Enantioselective Cycloaddition of Cyclopropyl Carboxamide with Alkyne was written by Liu, Qi-Sheng;Wang, De-Yin;Yang, Zhi-Jun;Luan, Yu-Xin;Yang, Jin-Fei;Li, Jiang-Fei;Pu, You-Ge;Ye, Mengchun. And the article was included in Journal of the American Chemical Society in 2017.Product Details of 93379-49-8 This article mentions the following:

A Ni-Al bimetallic catalyzed enantioselective cycloaddition reaction of cyclopropyl carboxamides with alkynes was developed. A series of cyclopentenyl carboxamides were obtained in up to 99% yield and 94% ee. The bifunctional-ligand-enabled bimetallic catalysis proved to be an efficient strategy for the C-C bond cleavage of unreactive cyclopropanes. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8Product Details of 93379-49-8).

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Product Details of 93379-49-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Resolution of alkyl pyridyl sulfoxides by complexation with a chiral host compound derived from tartaric acid was written by Zhu, Jin;Qin, Yong;He, Ze;Fu, Fang-Min;Zhou, Zhong-Yuan;Deng, Jin-Gen;Jiang, Yao-Zhong;Chau, Tay-Yuan. And the article was included in Tetrahedron: Asymmetry in 1997.Reference of 93379-49-8 This article mentions the following:

Alkyl pyridyl sulfoxides I (R = Me, Et) were prepared in high enantiomeric excess by resolution through inclusion complexation with a chiral host compound, (2R,3R)- or (2S,3S)-(-)-trans-4,5-bis(hydroxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane (II). The X-ray crystallog. structure anal. of complex (R,R)-(-)-II with (R)-(-)-I (R = Et) is reported. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8Reference of 93379-49-8).

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 93379-49-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D₂ template was written by Mewshaw, Richard E.;Webb, Michael B.;Marquis, Karen L.;McGaughey, Georgia B.;Shi, Xiaojie;Wasik, Theodore;Scerni, Rosemary;Brennan, Julie A.;Andree, Terrance H.. And the article was included in Journal of Medicinal Chemistry in 1999.Related Products of 3308-94-9 This article mentions the following:

A series of 4-(aminoethoxy)indoles I [R₁ = CH₂Ph, (CH₂)₄Ph, n- Bu, etc.; R₂ = H, Me; NR₁R₂ = isoquinolino; X = H, Cl, Y = H, COCF₃, Cl] and a related series of 4-(aminoethoxy)indolones II [R₁ = Me, CH₂Ph, 2-naphthyl, etc.; R₂ = H, Me, (CH₂)₂, CH₂; X = H, Cl, F] were synthesized and evaluated for their affinity for both the high- and low-affinity agonist states (D₂^High and D₂^Low, resp.) of the dopamine (DA) D₂ receptor. The 4-aminoethoxy derivatives I and II were designed as bioisosteric analogs based on the phenol prototype 3-HOC₆H₄OCH₂CH₂NHCH₂Ph. The indolones II were observed to have high affinity for the D₂^High receptor. Comparison of their previously reported chroman analogs with the more flexible 4-(aminoethoxy)indoles revealed the chroman analogs to be more potent, whereas little loss in D₂^High affinity was observed when comparing the 4-(aminoethoxy)indolones with their resp. chroman analogs. Several regions of the phenoxyethylamine framework were modified and recognized as potential sites to modulate the level of intrinsic activity. A conformational anal. was performed and a putative bioactive conformation was proposed which fulfilled the D₂ agonist pharmacophore criteria based on the McDermed model. Structure-activity relationships gained from these studies have aided in the synthesis of D₂ partial agonists of varying intrinsic activity levels. These agents should be of therapeutic value in treating disorders resulting from hypo- and hyperdopaminergic activity, without the side effects associated with complete D₂ agonism or antagonism. In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Related Products of 3308-94-9).

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 3308-94-9

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

1,2,4-Benzothiadiazine derivatives as α₁ and 5-HT_1A receptor ligands was written by Tait, Annalisa;Luppi, Amedeo;Franchini, Silvia;Preziosi, Elisa;Parenti, Carlo;Buccioni, Michela;Marucci, Gabriella;Leonardi, Amedeo;Poggesi, Elena;Brasili, Livio. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Reference of 4360-63-8 This article mentions the following:

A series of 1,2,4-benzothiadiazine derivatives I (R = H, Me, Cl) and II with an arylpiperazine moiety linked at position 3 of the heterocyclic ring were synthesized and assessed for their pharmacol. profiles at α₁-adrenoceptor subtypes (α_1A, α_1B and α_1D) by functional experiments and by in vitro binding studies at human cloned 5-HT_1A receptor. I (R = H) was identified as a α_1D antagonist (pK_bα_1D = 7.59; α_1D/α_1A > 389; α_1D/α_1B = 135) with high selectivity over 5-HT_1A receptor (5-HT_1A/α_1D < 0.01), while II (R = Cl) was characterized as a 5-HT_1A receptor ligand, highly selective over α_1D-adrenoceptor subtype (pK_i5-HT_1A = 8.04; 5-HT_1A/α_1D = 1096). Further pharmacol. studies demonstrated that II (R = Cl) was a partial agonist at 5-HT_1A receptor (E_max = 23, pD₂ = 6.92). In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Reference of 4360-63-8).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 4360-63-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Seasonal variation of the composition of essential oils from Piper cernuum Vell and Piper rivinoides Kunth, ADMET study, DFT calculations, molecular docking and dynamics studies of major components as potent inhibitors of the heterodimer methyltransferase complex NSP16-NSP10 SARS COV-2 protein was written by Alves Borges Leal, Antonio Linkoln;Fonseca Bezerra, Camila;Ferreira e Silva, Andressa Kelly;Everson da Silva, Luiz;Bezerra, Lucas Lima;Almeida-Neto, Francisco Wagner;Marinho, Emanuelle Machado;Celedonio Fernandes, Carla Freire;Nunes da Rocha, Matheus;Marinho, Marcia Machado;Coutinho, Henrique D. M.;Barreto, Humberto Medeiros;Rafaela Freitas Dotto, Ana;Amaral, Wanderlei do;Santos, Helcio Silva dos;Lima-Neto, Pedro de;Marinho, Emmanuel Silva. And the article was included in Journal of Biomolecular Structure and Dynamics.Formula: C11H12O3 This article mentions the following:

Coronavirus disease (COVID-19) has the virus that causes the SARS-CoV-2 severe acute respiratory syndrome, which has reached a pandemic proportion, with thousands of deaths worldwide already registered. In this context, the present study aimed to evaluate the influence of seasonality on the yield and chem. composition of the essential oils of Piper cernuum and Piper rivinoides as well as to evaluate the anti-SARS-CoV-2 potential of the major components of each oil by mol. docking and quantum chem. calculation (D. Functional Theory method), being possible indicate that the winter and autumn periods, the seasons of the year where it is possible to obtain the highest percentage of Piper cernuum and Piper rivinoides oils, resp. Regarding the anti-SARS-Cov-2 potential, the present work showed that the dihydroagarofuran present in Piper cernuum, presented a strong interaction with amino acid residues from Mpro, presenting a potential similar to Remdesivir, a drug for clin. use. Regarding methyltransferase, dihydroagarofuran (Piper cernuum) and myristicin (Piper rivinoids) showed better affinity, with important interactions at the active site of the inhibitor Sinefugin, suggesting a potential inhibitory effect of the heterodimer methyltransferase complex NSP16-NSP10 SARS Cov-2. Mol. docking and mol. dynamics studies represent an initial step, being indicative for future in vitro studies of dihydroagarofuran and myristicin, as possible pharmacol. tools for COVID-19. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Formula: C11H12O3).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C11H12O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem