Category: Dioxole

Synthesis and characterization of 4-substituted ethyl 2-methyl-6,7-methylenedioxy-3-quinolinecarboxylate was written by Zhu, Zhaofu. And the article was included in Huaxue Yanjiu Yu Yingyong in 2003.COA of Formula: C9H9NO3 This article mentions the following:

Et 4-R-2-methyl-6,7-methylenedioxy-3-quinolinecarboxylate (R = Me, Et, Pr, or isopropyl) was prepared from benzodioxole by acylation, nitration, reduction, and condensation in a yield of 74-87%. The mol. structures were determined by IR, ¹H-NMR, and MS. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2COA of Formula: C9H9NO3).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.COA of Formula: C9H9NO3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of vanillin 1,2-propylene glycol acetal by phosphomolybdic acid was written by Jin, Lie;Zhou, Tong-wu. And the article was included in Huaxue Gongchengshi in 2010.Category: dioxole This article mentions the following:

Vanillin 1,2-propylene glycol acetal was synthesized from vanillin and 1,2-propylene glycol using H₃PO₃-MoO₃-xH₂O as the catalyst. Factors influencing the yield, such as the molar ratio of starting materials, time, catalyst species and amount, and different water entraining agents, were studied and the better reaction conditions were determined The factors influencing the synthesis were studied and the optimal reaction conditions were found as follows: a molar ratio of cinnamaldehyde/ethylene glycol = 1.0/1.3, a catalyst dosage of 0.3%, a cyclohexane amount of 15 mL and a reaction time of 4.5 h. The selectivity was above 98% and the product yield was 94.58%. The structure of vanillin 1,2-propylene glycol acetal was identified by means of IR and GC. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Category: dioxole).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

BOIMPYs: Rapid Access to a Family of Red-Emissive Fluorophores and NIR Dyes was written by Patalag, Lukas J.;Jones, Peter G.;Werz, Daniel B.. And the article was included in Angewandte Chemie, International Edition in 2016.Product Details of 15186-48-8 This article mentions the following:

A fundamental, highly fluorescent, and easily accessible scaffold derived from the BODIPY core is reported. The use of benzimidazole as a bridging ligand at the meso position enables the binding of two BF₂ units to provide sufficient rigidity and enhanced electron-withdrawing strength. Absorption and emission events thus take place in the red (λ≈600 nm); the fluorescence quantum yields can reach unity (0.96) and show little dependence on solvent polarity. The synthetic route was shortened to two steps starting from com. available precursors while the preparation is modular and tolerates various pyrrole and benzimidazole moieties. Fluoride replacement by propynyl groups, various halogenations, as well as Knoevenagel-type condensations were applied to extend the versatility of these new photostable fluorophores, which we termed BOIMPYs. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8Product Details of 15186-48-8).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Product Details of 15186-48-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of 3-aryl-5-R-thio-[1,3]thiazolo[4′,5′:4,5]pyrimido[1,6-a]benzimidazole-2(3H)-thiones was written by Ivachtchenko, Alexandre;Kovalenko, Sergiy;Parkhomenko, Olexiy;Chernykh, Valentyn. And the article was included in Heterocyclic Communications in 2002.SDS of cas: 4360-63-8 This article mentions the following:

A new five-component condensation of isothiocyanates R¹C₆H₄NCS (R¹ = 4-EtO, 3-MeO), sulfur, 2-(cyanomethyl)benzimidazole, triethylamine and carbon disulfide furnishes triethylammonium 3-aryl-[1,3]thiazolo[4′,5′:4,5]pyrimido[1,6-a]benzimidazole-2(3H)-thioxo-5-thiolates I, the alkylation of which gives 3-aryl-5-R-thio-[1,3]thiazolo[4′,5′:4,5]pyrimido[1,6-a]benzimidazole-2(3H)-thiones II (R² = Me, CH₂CO₂Et, Q). In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8SDS of cas: 4360-63-8).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.SDS of cas: 4360-63-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of 2-(1,4-dioxaspiro[4.5]decan-6-yl)acrylamides from 2-acetylcyclohexanone via palladium-catalysed aminocarbonylation was written by Farkas, Roland;Petz, Andea;Kollar, Laszlo. And the article was included in Monatshefte fuer Chemie in 2015.Name: 1,4-Dioxaspiro[4.5]decane This article mentions the following:

6-(1-Iodovinyl)-1,4-dioxaspiro[4.5]decane, an iodoalkene obtained from 2-acetylcyclohexanone via ethylene ketal formation, hydrazone formation and iodination, was aminocarbonylated in the presence of a palladium-phosphine precatalyst. Systematic investigations revealed that 2-(1,4-dioxaspiro[4.5]decan-6-yl)acrylamides I [R¹ = H; R² = tBu, CH₂CO₂Me, CH(CH₃)CO₂Me, CH{CH(CH₃)₂}CO₂Me; R¹R² = (CH₂)₅, (CH₂)O(CH₂)₂, CH(CO₂Me)(CH₂)₃] can be obtained in high yields via palladium-catalyzed aminocarbonylation. The influence of the amine nucleophiles and of the reaction conditions on the isolated yields was investigated. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Name: 1,4-Dioxaspiro[4.5]decane).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Name: 1,4-Dioxaspiro[4.5]decane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of the all-cis-trimethyldecalin fragment of unusual terpenes by radical-mediated protonolysis of an alkylboron derivative was written by Villa, Giorgio;Bradshaw, Ben;Burki, Cedric;Bonjoch, Josep;Renaud, Philippe. And the article was included in Tetrahedron Letters in 2014.Recommanded Product: 126-39-6 This article mentions the following:

The synthesis of an enantiopure building-block (I) with a contiguous all-cis-trimethyldecalin motif embedded in unusual terpenes is described. Starting from the Wieland-Miescher ketone, the key step is a one-pot hydroboration of an exocyclic methylene double bond promoted by disiamylborane and radical-mediated protonolysis of the corresponding alkylborane using 4-tert-butylcatechol. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Recommanded Product: 126-39-6).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 126-39-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Enantioselective conjugate additions of aldoximes to 3-crotonoyl-2-oxazolidinone and 1-crotonoyl-3-phenyl-2-imidazolidinone catalyzed by the aqua complex between R,R-DBFOX/Ph and zinc(II) perchlorate was written by Nakama, Kimitaka;Seki, Sumito;Kanemasa, Shuji. And the article was included in Tetrahedron Letters in 2002.Safety of ((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol) This article mentions the following:

Conjugate addition reactions of aldoximes to 3-crotonoyl-2-oxazolidinone and to 1-crotonoyl-3-phenyl-2-imidazolidinone are accelerated in the presence of a catalytic amount of Lewis acids. The chiral ligands included (4R,4′R)-2,2′-(4,6-dibenzofurandiyl)bis[4,5-dihydro-4-phenyloxazole] (I), (4S,4′S)-2,2′-(1-methylethylidene)bis[4-(1,1-dimethylethyl)-4,5-dihydrooxazole], (4R,4′R)-2,2′-(1-methylethylidene)bis[4,5-dihydro-4-phenyloxazole], 2,6-bis[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]pyridine, (4S,5S)-2,2-dimethyl-α,α,α’,α’-tetra-1-naphthalenyl-1,3-dioxolane-4,5-dimethanol. The most effective catalyst was derived from zinc perchlorate hexahydrate and I. The reaction of 2-furancarboxaldehyde oxime in dichloromethane in the presence of I-zinc perchlorate hexahydrate complex gave a moderate enantioselectivity of 64% ee at 0°C. Reactions using other metal complexes are also discussed. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol) (cas: 171086-52-5Safety of ((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol)).

((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol) (cas: 171086-52-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Safety of ((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol)

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Investigation of the inhibition of leukotriene A₄ hydrolase was written by Ollmann, Ian R.;Hogg, J. Heather;Munoz, Benito;Haeggstroem, Jesper Z.;Samuelsson, Bengt;Wong, Chi-Huey. And the article was included in Bioorganic & Medicinal Chemistry in 1995.Synthetic Route of C6H11BrO2 This article mentions the following:

In an effort to better understand the favorable binding interactions between the reversible picomolar inhibitor 3-(4-benzyloxyphenyl)-2-(R)-amino-1-propanethiol (1) and leukotriene A₄ (LTA₄) hydrolase (EC 3.3.2.6), we prepared a number of derivatives of 1–L and other related structures, and assayed their inhibition of LTA₄ hydrolase-catalyzed hydrolysis of L-alanine-p-nitroanilide. The inhibition data was analyzed using a weighted non-linear least-squares curve fitting computer program developed for this purpose to fit data derived under the non-Michaelis-Menten condition of [T]_t < [E]_t. The free thiol is necessary for sub-micromolar binding and the enzyme prefers the R enantiomer over the S enantiomer, in contrast to the stereoselectivity displayed towards bestatin, an inhibitor of somewhat similar structure. Substitution of acid moieties around the periphery of the benzyloxyphenyl portion of 1–L leads to substantially decreased binding, suggesting that this group resides within a large hydrophobic pocket when bound to the enzyme. Possible LTA₄ binding modes in the active site of LTA₄ hydrolase, including a possible direct role for the carboxylic acid of LTA₄ in the enzyme-catalyzed hydrolysis of leukotriene A₄, are discussed. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Synthetic Route of C6H11BrO2).

2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Synthetic Route of C6H11BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of a novel multi-SO₃H functionalized ionic liquid and its catalytic activities was written by Sun, Xudong;Xiao, Huiquan;Du, Yijun;Zhang, Jingjing;Liang, Xuezheng;Qi, Chenze. And the article was included in Kinetics and Catalysis in 2012.Computed Properties of C8H14O2 This article mentions the following:

A novel multi-SO₃H functionalized ionic liquid is synthesized and a detailed account of its catalytic activities in acetalization and acetylation is given. The results showed that the ionic liquid is very efficient in the conventional acid-catalyzed reactions with good to excellent yields within a short reaction time. Operational simplicity, small amounts required, low cost of the catalyst, high yields, scalability and reusability are the key features of this methodol., which indicates the high potentialities of the novel ionic liquid to be used in environmentally friendly processes. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Computed Properties of C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and Unexpected Transformation of 5-[(1,3-Dioxolan-2-ylmethyl)sulfanyl]-1H-pyrrol-2-amine into 5-{[2-(2-Hydroxyethoxy)ethenyl]sulfanyl}-1H-pyrrol-2-amine in the Presence of a Superbase was written by Nedolya, N. A.;Tarasova, O. A.;Albanov, A. I.;Trofimov, B. A.. And the article was included in Russian Journal of Organic Chemistry in 2021.Category: dioxole This article mentions the following:

Successive one-pot reactions of monolithiated N,N-diethylprop-2-yn-1-amine with 2-(ethenyloxy)ethyl isothiocyanate and 2-(bromomethyl)-1,3-dioxolane afforded I in 91% yield. In the system t-BuOK-DMSO at room temperature (1 h), the product was converted to E/Z-II (yield 68%) instead of expected 1-vinyl derivative In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Category: dioxole).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem