Category: Dioxole

A practical RuCl₃-catalyzed oxidation using trichloroisocyanuric acid as a stoichiometric oxidant under mild nonacidic conditions was written by Yamaoka, Hidenori;Moriya, Narimasa;Ikunaka, Masaya. And the article was included in Organic Process Research & Development in 2004.Electric Literature of C12H20O6 This article mentions the following:

The combined use of catalytic RuCl₃ and stoichiometric trichloroisocyanuric acid in the presence of n-Bu₄NBr and K₂CO₃ allowed smooth oxidation of primary alcs. to carboxylic acids. Secondary alcs. can be oxidized to ketones when using the same set of the reagents. By proceeding under the nonacidic biphasic conditions dispensing with hazardous reagents, the oxidation reactions were applicable to structurally diverse alcs., easy to work up, environmentally benign, and basically high-yielding. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Electric Literature of C12H20O6).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Electric Literature of C12H20O6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of vanillin 1,2-propylene glycol acetal catalyzed by iodine was written by Wang, Yong-lan;Bo, Hui-ying;Wang, Hong-she. And the article was included in Huaxue Gongchengshi in 2013.COA of Formula: C11H14O4 This article mentions the following:

Vanillin 1,2-propylene glycol acetal was synthesized through the condensation of vanillin with 1,2-propylene glycol using iodine as a catalyst. The effects of the molar ratio of reactant, the amount of catalyst, reaction temperature and reaction time on the yield of product were discussed. The results showed that the optimized reaction conditions are as follows: the molar ratio of vanillin (0.1 mol) to 1,2-propylene glycol (0.18 mol) is 1 : 1.8; the amount of catalyst is 1.2 g, reaction temperature is 60°C and the reaction time is 20 min. Under the optimum conditions mentioned above, the yield of vanillin 1,2-propylene glycol acetal reached more than 91.3%. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2COA of Formula: C11H14O4).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.COA of Formula: C11H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and cardiotonic activity of a series of substituted 4-alkyl-2(1H)-quinazolinones was written by Bandurco, Victor T.;Schwender, Charles F.;Bell, Stanley C.;Combs, Donald W.;Kanojia, Ramesh M.;Levine, Seymour D.;Mulvey, Dennis M.;Appollina, Mary A.;Reed, Marianne S.. And the article was included in Journal of Medicinal Chemistry in 1987.Reference of 28657-75-2 This article mentions the following:

The synthesis, cardiac fraction III cyclic nucleotide phosphodiesterase (PDE-III) inhibition, and pos. inotropic activity of a series of 2(1H)-quinazolinones are reported. A general synthesis of the series involves the cyclization of 2-aminoacetophenones with KOCN in AcOH. Modifications at the 4-position of the quinazoline nucleus are best achieved by forming the intermediate N₁-acyl-N₃-phenylurea from the appropriate substituted PhNCO and amide. Polyphosphoric acid effects cyclizaiton to the quinazoline product. Generally the structure-activity relationships for the series parallel the 5-point model previously published for PDE-III inhibition. The most active analog of the series is 5,6-dimethoxy-4-methyl-2(1H)-quinazolinone (I) (ORF 16,600), which has ca. twice the i.v. potency of amrinone and is being developed as an oral cardiotonic. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Reference of 28657-75-2).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Reference of 28657-75-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Studies on tridecaptin B₁, a lipopeptide with activity against multidrug resistant Gram-negative bacteria was written by Cochrane, Stephen A.;Lohans, Christopher T.;van Belkum, Marco J.;Bels, Manon A.;Vederas, John C.. And the article was included in Organic & Biomolecular Chemistry in 2015.Category: dioxole This article mentions the following:

Previously, other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type IIA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B₁. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B₁ is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-neg. bacteria, a finding that is timely to the current problem of antibiotic resistance. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Category: dioxole).

2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation of SO₄^2-/TiO₂-MoO₃ solid superacid and its catalytic activity in acetalation and ketalation was written by Yang, Shuijin;Liang, Yongguang;Yu, Xieqing;Sun, Jutang. And the article was included in Chinese Journal of Chemical Engineering in 2005.Recommanded Product: 126-39-6 This article mentions the following:

The SO₄^2-/TiO₂-MoO₃ solid superacid was prepared and its catalytic activity under different synthetic conditions was examined with esterification of n-butanoic acid and Bu alc. as probing reaction. Optimum conditions for catalyst preparation were determined, i.e., the mass ratio of MoO₃ is 25%, the calcination temperature 450°, and the soaked consistency of H₂SO₄ is 0.5 mol·L^-1. The superacid catalyst was evaluated in the preparation of six ketals and acetals. Under molar ratio of aldehyde/ketone to glycol 1:1.5, mass ratio of catalyst to reactants of 0.5%, and reaction time of 1.0 h, the yield of ketals and acetals was up to 63.2%. The catalyst can be easily recovered and reused. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Recommanded Product: 126-39-6).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 126-39-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Indium-catalyzed annulation of o-acylanilines with alkoxyheteroarenes: synthesis of heteroaryl[b]quinolines and subsequent transformation to cryptolepine derivatives was written by Yonekura, Kyohei;Shinoda, Mika;Yonekura, Yuko;Tsuchimoto, Teruhisa. And the article was included in Molecules in 2018.Synthetic Route of C9H9NO3 This article mentions the following:

An efficient method for the synthesis of heteroaryl[b]quinolines such as I [R = H, 4-OH, 2,3-di-MeO, etc.; R¹ = Me, i-Pr, Ph, etc.; X = N, S] was developed via annulation of o-acylanilines and MeO-heteroarenes using an indium Lewis acid as catalyst for tandem N-C and C-C bond formation. A series of indolo[3,2-b]quinolines was subsequently transformed to structurally unprecedented cryptolepine derivatives Mechanistic studies showed that the N-C bond formation was followed by the C-C bond formation. The indium-catalyzed annulation reaction thus started with the nucleophilic attack of the NH₂ group of o-acylanilines to the MeO-connected carbon atom of the heteroaryl ring in an S_NAr fashion and thereby the N-C bond was formed. The resulting intermediate then cyclized and gave C-C bond through the nucleophilic attack of the heteroaryl-ring-based carbon atom to the carbonyl carbon atom, provided the HA[b]Q after aromatizing dehydration. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Synthetic Route of C9H9NO3).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Synthetic Route of C9H9NO3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Zn/CuI-Mediated Coupling of Alkyl Halides with Vinyl Sulfones, Vinyl Sulfonates, and Vinyl Sulfonamides was written by Zhao, Matthew M.;Qu, Chuanxing;Lynch, Joseph E.. And the article was included in Journal of Organic Chemistry in 2005.Category: dioxole This article mentions the following:

A novel high-yielding Zn/CuI-mediated coupling of alkyl halides with vinyl sulfones, vinyl sulfonates, and vinyl sulfonamides is described. This protocol is applicable for primary, secondary, and tertiary alkyl iodides and bromides. Alkyl chlorides and aryl and vinyl halides were unreactive under the reaction conditions. Formamide was found to be a superior solvent for obtaining high yields. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Category: dioxole).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Fixation of carbon dioxide concurrently or in tandem with free radical polymerization for highly transparent polyacrylates with specific UV absorption was written by Liu, Bin;Zhang, Ying-Ying;Zhang, Xing-Hong;Du, Bin-Yang;Fan, Zhi-Qiang. And the article was included in Polymer Chemistry in 2016.Category: dioxole This article mentions the following:

It is still a challenging issue to combine the coupling reaction and free radical polymerization (FRP) for well-controlled and efficient synthesis of polyacrylates bearing the cyclic carbonate group from carbon dioxide (CO₂) and vinyl epoxides. This work describes the efficient catalytic synthesis of poly(2-oxo-1,3-dioxolane-4-yl)methyl methacrylate (PDOMA) from CO₂ and glycidyl methacrylate (GMA) via concurrent or tandem combination of the coupling reaction and FRP. In a concurrent reaction, GMA/CO₂ coupling with 100% oxirane conversion was achieved by using a nanolamellar zinc-cobalt (3) double metal cyanide complex [Zn-Co³⁺ DMCC] (0.30 mol% Zn related to GMA) with cetyltrimethylammonium bromide (0.65 mol% related to GMA) as the catalyst, and PDOMA was obtained via the concurrent free radical polymerization of carbon-carbon double bonds in the presence or absence of addnl. free radical initiator. In the tandem process, (2-oxo-1,3-dioxolane-4-yl)methyl methacrylate (DOMA) was firstly synthesized via GMA/CO₂ coupling catalyzed by Zn-Co(3) DMCC/CTAB and purified by simply passing through a basic aluminum oxide column. DOMA could be polymerized via solution or emulsion polymerization, leading to linear PDOMA or PDOMA nanoparticles with minimized metal residues. The obtained PDOMAs were soluble in strong polar solvents and presented excellent light transmittance in a wavelength range of 314-800 nm (93%) and perfect UV absorption in a wavelength range of 200-313 nm (close to 100%), while most of the common polyacrylates cannot absorb UV light. In addition, the PDOMAs had tunable number-average mol. weights (M_ns) of 12.0-132.0 kg mol^-1 and high glass transition temperatures (T_gs) of 121.0-140.4 °C. Such CO₂-based PDOMAs could be potentially used as wavelength-specific UV-absorbing materials. This work provides a simple and useful synthetic path to directly utilize CO₂ by combining two reaction mechanisms. In the experiment, the researchers used many compounds, for example, (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5Category: dioxole).

(2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Al-free Zr-beta zeolite as a selective catalyst for the ketalization of glycerol was written by Vannucci, Julian A.;Legnoverde, Maria S.;Dalla Costa, Bruno O.;Basaldella, Elena I.;Nichio, Nora N.;Pompeo, Francisco. And the article was included in Molecular Catalysis in 2022.Application of 100-79-8 This article mentions the following:

Two Zr-beta zeolites were synthesized using different methods. Method 1 consisted in the formation of a dealuminated zeolite beta seed followed by Zr incorporation and thermal treatment (ZBZr₁). In Method 2, zeolite beta was prepared and then, the dealumination and subsequent Zr incorporation were performed (ZBZr₂). These materials were tested in the ketalization of glycerol with acetone and compared with a SBAsulf. Both preparation methods incorporate Zr in the zeolitic framework, and no ZrO₂ is detected. Method 1 developed crystallites with an average size of 260 nm, Si/Zr ratio ∼100, total amount of acid sites of 0.375 mmol.g^-1 and a ratio of Bronsted to Lewis acid sites of 1.9. In the case of Method 2, values of 1500 nm, ∼86, 0.32 mmol.g^-1 and 0.7 were obtained, resp. The ZBZr₂ sample presented low catalytic activity, possibly due to diffusion limitations. The turnover frequency (TOF) was calculated as 44.84 and 60.37 min^-1 for ZBZr₁ and SBA_sulf , resp. After one cycle of reaction, both ZBZr₁ and SBA_sulf showed a decrease in the glycerol conversion, however, the selectivity remained constant in the ZBZr₁ material after the reaction cycle and the catalytic activity could be reestablished after a thermal treatment. In the experiment, the researchers used many compounds, for example, (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8Application of 100-79-8).

(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 100-79-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of butanone ethylene ketal with SO₄^2-/TiO₂-La₂O₃ was written by Bai, Ai-min;Du, Xin-xian;Yang, Shui-jin. And the article was included in Huagong Keji in 2007.Recommanded Product: 126-39-6 This article mentions the following:

Butanone ethylene ketal was synthesized from butanone and ethylene glycol in the presence of SO₄^2-/TiO₂-La₂O₃. The factors influencing the synthetic process were discussed and the best conditions were found out. The optimum conditions are: molar ratio of butanone to ethylene glycol is 1:2.0, the quantity of catalyst is equal to 0.50% of feed stocks, the reaction temperature is 79-89°C, and the reaction time is 2.0 h. SO₄^2-/TiO₂-La₂O₃ is an excellent catalyst. For synthesizing butanone ethylene ketal and its yield can reach over 58.1%. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Recommanded Product: 126-39-6).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 126-39-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem