Day: February 22, 2023

Synthesis of vanillin propylene glycol acetal over different molecular sieve catalysts was written by Wang, Wen-lan;Huang, Yong;Meng, Qing-lei;Liu, Bai-jun. And the article was included in Huaxue Gongchengshi in 2009.Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol This article mentions the following:

The vanillin 1,2-propylene glycol acetal was synthesized using vanillin and 1,2-propylene glycol as starting materials and HZSM-5, HY, H beta, HMCM-22, HMCM-41 different type mol. sieve as the catalyst. The catalysts were characterized by means of N₂ adsorption-desorption and FT-IR of adsorption pyridine. The results indicate that the HMCM-22 mol. sieve has the higher activity and the each kind of mol. sieve active order is: HMCM-22 > H beta > USY > HY > HZSM-5 > HMCM-41. The higher activity was due to the large secondary pore structure of HMCM-22 mol. sieve and the suitable acidity. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Chiral Aluminum Complex Controls Enantioselective Nickel-Catalyzed Synthesis of Indenes: C-CN Bond Activation was written by Zhang, Tao;Luan, Yu-Xin;Zheng, Su-Juan;Peng, Qian;Ye, Mengchun. And the article was included in Angewandte Chemie, International Edition in 2020.Synthetic Route of C47H38O4 This article mentions the following:

A chiral aluminum complex controlled, enantioselective nickel-catalyzed domino reaction of aryl nitriles and alkynes proceeding by C-CN bond activation was developed. The reaction provides various indenes, bearing chiral all-carbon quaternary centers, under mild reaction conditions in yields of 32 to 91% and ee values within the 73-98% range. The reaction mechanism and aspects of stereocontrol were investigated by DFT calculations Thus, e.g., domino C-CN bond activation/insertion reaction of nitrile I with 4-octyne in presence of Ni(cod)₂, tris(4-methoxyphenyl)phosphine, a chiral TADDOL and Al(iBu)₃ afforded indene II (86%, 92% ee). In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol) (cas: 171086-52-5Synthetic Route of C47H38O4).

((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol) (cas: 171086-52-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Synthetic Route of C47H38O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Hydroxyl-Functionalized Imidazoles: Highly Active Additives for the Potassium Iodide-Catalyzed Synthesis of 1,3-Dioxolan-2-one Derivatives from Epoxides and Carbon Dioxide was written by Werner, Thomas;Tenhumberg, Nils;Buettner, Hendrik. And the article was included in ChemCatChem in 2014.Application of 13818-44-5 This article mentions the following:

4(5)-(Hydroxymethyl)imidazole and potassium iodide were identified as an efficient catalyst system for the cycloaddition of epoxides, e.g., 1,2-butylene oxide, and carbon dioxide producing 1,3-dioxolan-2-one derivatives, e.g., 4-ethyl-1,3-dioxolan-2-one, under solvent-free conditions. The high activity of the catalyst system even at 60 °C was probably due to synergistic effects between potassium iodide and the substituted imidazole. Various functionalized and nonfunctionalized terminal epoxides as well as internal epoxides were converted into the corresponding cyclic carbonates in high yields (up to 99 %) under mild reaction conditions within a short reaction time. Compared with the previously reported amino alcs., e.g. triethanolamine based catalyzed synthesis of cyclic carbonates, the catalyst system described herein demonstrates a higher activity toward a broad substrate scope. In the experiment, the researchers used many compounds, for example, (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5Application of 13818-44-5).

(2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 13818-44-5

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Antitumor Agents. 211. Fluorinated 2-Phenyl-4-quinolone Derivatives as Antimitotic Antitumor Agents was written by Xia, Yi;Yang, Zheng-Yu;Xia, Peng;Hackl, Torben;Hamel, Ernest;Mauger, Anthony;Wu, Jiu-Hong;Lee, Kuo-Hsiung. And the article was included in Journal of Medicinal Chemistry in 2001.HPLC of Formula: 28657-75-2 This article mentions the following:

Fluorinated 2-phenyl-4-quinolone derivatives were synthesized and evaluated in National Cancer Institute’s 60 human tumor cell line in vitro screen. From the results, the ketone moiety plays an essential role in activity. Among the compounds tested, 2-(2-fluorophenyl)-6-pyrrol-1-yl-4-quinolone (I) exhibited the most potent cytotoxic activities (log GI₅₀ < -8.00) against renal and melanoma tumor cell lines. I was also a potent inhibitor of tubulin polymerization (IC₅₀ = 0.46 μM) and of radiolabeled colchicine binding to tubulin, with activities comparable to those of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2HPLC of Formula: 28657-75-2).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.HPLC of Formula: 28657-75-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Effect of polymer matrices of gels bearing a sulfo group on their catalytic properties for acetalization of glycerol to solketal and esterification of oleic acid to ethyl oleate was written by Tokuyama, Hideaki;Ohno, Hiroki;Fujita, Tara. And the article was included in Reactive & Functional Polymers in 2021.Product Details of 100-79-8 This article mentions the following:

A novel type of copolymer gel bearing the sulfo group was developed as a heterogeneous acid catalyst for the solvent free acetalization of glycerol with acetone to form a desirable solketal, as well as the solvent free esterification of oleic acid with ethanol to form Et oleate as a biodiesel fuel. The copolymer gels were synthesized by the copolymerization of a primary monomer (ethoxy diethyleneglycol acrylate (EDGA), N-isopropylacrylamide (NIPA), etc.) with 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS). The copolymer gels, such as EDGA-co-AMPS gel and NIPA-co-AMPS gel, successfully catalyzed both reactions with a higher reaction rate than those of AMPS gel and the conventional sulfonic ion exchange resin (Amberlyst). According to Le Chatelier’s principle, if a gel catalyst absorbs reactants well, and expels or poorly absorbs products, the apparent rate of the reaction occurring within the gel is enhanced. This hypothesis was examined by analyzing the solution absorptions of these gels and their reaction rates, including Eley-Rideal kinetic anal. In the experiment, the researchers used many compounds, for example, (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8Product Details of 100-79-8).

(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Product Details of 100-79-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of vanillin 1,2-propylene glycol acetal catalyzed by H₃PMo₁₂O₄₀ was written by Jiang, Wei-hua;Meng, Qi;Xi, Hai-tao;Jiang, Yan;Sun, Xiao-qiang. And the article was included in Huaxue Shiji in 2009.SDS of cas: 68527-74-2 This article mentions the following:

A method for the synthesis of the title compound [i.e., 2-methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, vanillin 1,2-propylene glycol acetal] is reported here. Vanillin 1,2-propylene glycol acetal was synthesized from vanillin [i.e., 4-hydroxy-3-methoxybenzaldehyde] and 1,2-propylene glycol using H₃PMo₁₂O₄₀ as the catalyst. Factors influencing the product formation, such as molar ratio of reactants, time, catalyst type and amount, and different water entrainment agents, were studied and optimized reaction conditions were determined Reaction conditions were found as follows: molar ratio of aldehyde/glycol = 1.0/1.3, catalyst dosage of 0.3%, a cyclohexane amount of 15 mL, and a reaction time of 4.5 h. The selectivity was above 98% and the product yield was 94.58%. The product structure was determined by IR, GC, NMR. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2SDS of cas: 68527-74-2).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 68527-74-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Essential Oil of Deverra tortuosa Aerial Parts: Detailed Chemical Profile, Allelopathic, Antimicrobial, and Antioxidant Activities was written by Fayed, Eman M.;Abd-EIGawad, Ahmed M.;Elshamy, Abdelsamed I.;El-Halawany, El-Sayed F.;EI-Amier, Yasser A.. And the article was included in Chemistry & Biodiversity in 2021.Synthetic Route of C11H12O3 This article mentions the following:

Essential oils (EOs) are a promising group of natural products of the aromatic plants due to their various biol. effects such as allelopathic, antioxidant, antimicrobial activities. The present study aimed to construct the detailed chem. profile of the EO derived from Deverra tortuosa aerial parts along with assessing its allelopathic, antimicrobial, and antioxidant potentialities. The EO was extracted by hydrodistillation and analyzed via gas chromatog.-mass spectrometry (GC/MS). The allelopathic activity of the EO was assessed against the germination and seedling growth of the weed Chenopodium murale. Also, the EO was tested against five microbes. The antioxidant activity was determined using the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). The GC/MS anal. of EO revealed the presence of 86 compounds with a preponderance of oxygenated sesquiterpenes and monoterpene hydrocarbons. Widdrol, β-phellandrene, piperitol, cubedol, α-terpinene, (E)-10-heptadecen-8-ynoic acid Me ester, citronellyl tiglate, and m-cymene were the major compounds A comparative profile was established between the EOs constituents of our study with the documented EOs of D. tortuosa and the other Deverra species around the world via agglomerative hierarchical clustering (AHC) and principal components anal. (PCA). The EO showed a substantial allelopathic activity against C. murale, as well as it showed considerable antimicrobial and antioxidant activities. Thereby, the EO of D. tortuosa could be considered as a promising environmental-friendly bioherbicide against weeds. Also, it could be integrated into food preservation due to its potent antimicrobial and antioxidant activities. However, further study is recommended for more characterization of the major compounds and evaluation of their activities, either singular or synergistic, and assess their efficiency and biosafety. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Synthetic Route of C11H12O3).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Synthetic Route of C11H12O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

I₂-doped chitosan: an easily recoverable and efficient catalyst for acetalization of carbonyl compounds with diols was written by Liu, Chun-Sheng;Luo, Gen-Xiang. And the article was included in Polymer-Plastics Technology and Engineering in 2009.Computed Properties of C6H12O2 This article mentions the following:

Chitosan-I₂ is prepared by doping of chitosan with iodine (I₂). Chitosan-I₂ are characterized by phys. and spectral methods. Chitosan-I₂ is used as catalyst for the first time in acetalization of carbonyl compounds The catalyzed acetalization of benzaldehyde and glycol is conducted in excellent yields with simple and more environmental benign procedure. The use of chitosan-I₂ catalyst is feasible because of its easy preparation, easy handling, stability, easy recovery, reusability, good activity and eco-friendly. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Computed Properties of C6H12O2).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C6H12O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Discovery of β-D-2′-deoxy-2′-dichlorouridine nucleotide prodrugs as potent inhibitors of hepatitis C virus replication was written by Pinho, Pedro;Kalayanov, Genadiy;Westerlind, Hans;Rosenquist, Aasa;Waehling, Horst;Sund, Christian;Almeida, Maria;Ayesa, Susana;Tejbrant, Jan;Targett-Adams, Paul;Eneroth, Anders;Lindqvist, Annelie. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Category: dioxole This article mentions the following:

Discovery of sofosbuvir has radically changed hepatitis C treatment and nucleoside/tide NS5B inhibitors are now viewed as one of the key components in combination therapies with other direct-acting antiviral agents. As part of our program to identify new nucleoside inhibitors of HCV replication, we now wish to report on the discovery of β-D-2′-deoxy-2′-dichlorouridine nucleotide prodrugs as potent inhibitors of HCV replication. Although, cytidine analogs have long been recognized to be metabolized to both cytidine and uridine triphosphates through the action of cytidine deaminase, uridine analogs are generally believed to produce exclusively uridine triphosphate. Detailed investigation of the intracellular metabolism of our newly discovered uridine prodrugs, as well as of sofosbuvir, has now revealed the formation of both uridine and cytidine triphosphates. This occurs, not only in vitro in cell lines, but also in vivo upon oral dosing to dogs. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8Category: dioxole).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation of the WO_X/MCM-41 Solid Acid Catalyst and the Catalytic Performance for Solketal Synthesis was written by Huang, Yixuan;Zhang, Guangcai;Zhang, Qinhui. And the article was included in ACS Omega in 2021.Electric Literature of C6H12O3 This article mentions the following:

In the present work, an efficient and stable WO_X/MCM-41 solid acid catalyst was prepared by the wet impregnation method. The characterization of powder X-ray diffraction, transmission electron microscopy, UV-visible, H₂ temperature-programmed reduction, XPS, NH₃ temperature-programmed desorption, and N₂ adsorption-desorption isotherms confirmed that the impregnation amount and calcination temperature of WO_X speciation affected the dispersity and acidity of the resulting catalyst. This WO_X/MCM-41 solid acid catalyst was subsequently applied in the ketalization reaction of glycerol and acetone to produce solketal. By catalyst screening and reaction condition optimization, WO_X/MCM-41 obtained by impregnating 20 weight % and calcining at 350°C exhibited the highest solketal yield and catalytic stability. In the experiment, the researchers used many compounds, for example, (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8Electric Literature of C6H12O3).

(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Electric Literature of C6H12O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem