Day: February 23, 2023

Parallel synthesis of a library of bidentate protein tyrosine phosphatase inhibitors based on the α-ketoacid motif was written by Chen, Yen Ting;Seto, Christopher T.. And the article was included in Bioorganic & Medicinal Chemistry in 2004.Application In Synthesis of 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone This article mentions the following:

Protein tyrosine phosphatases (PTPases) regulate intracellular signal transduction pathways by controlling the level of tyrosine phosphorylation in cells. These enzymes play an important role in a variety of diseases including type II diabetes and infection by the bacterium Yersinia pestis, which is the causative agent of bubonic plague. This report describes the synthesis, using parallel solution-phase methods, of a library of 104 potential inhibitors of PTPases. The library members are based on the bis(aryl α-ketocarboxylic acid) motif that incorporates a carboxylic acid on the central benzene linker. This carboxylic acid was coupled with a variety of different aromatic amines through an amide linkage. The aromatic component of the resulting amides is designed to make contacts with residues that surround the active site of the PTPase. The library was screened against the Yersinia PTPase and PTP1B. Based upon the screening results, four members of the library were selected for further study. These four compounds were evaluated against the Yersinia PTPase, PTP1B, TCPTP, CD45, and LAR. Compound 14 has an IC₅₀ value of 590 nM against PTP1B and is a reversible competitive inhibitor. This affinity represents a greater than 120-fold increase in potency over compound 2, the parent structure upon which the library was based. A second inhibitor, compound 12, has an IC₅₀ value of 240 nM against the Yersinia PTPase. In general, the selectivity of the inhibitors for PTP1B was good compared to LAR, but modest when compared to TCPTP and CD45. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Application In Synthesis of 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Application In Synthesis of 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of (±)-Serralongamine A and the Revised Structure of Huperzine N was written by Saborit, Gisela V.;Bosch, Caroline;Parella, Teodor;Bradshaw, Ben;Bonjoch, Josep. And the article was included in Journal of Organic Chemistry in 2016.Synthetic Route of C6H12O2 This article mentions the following:

A revised structure for the Lycopodium alkaloid huperzine N,is proposed and confirmed by synthesis. The key synthetic steps involve an epimerization of a cis-5-oxodecahydroquinoline to the corresponding trans isomer and a coupling, followed by a diastereoselective hydrogenation using Wilkinson’s catalyst to incorporate the pyridylmethyl moiety. This route allowed the alkaloid serralongamine A, I, to be synthesized for the first time, and two addnl. steps led to the revised structure of huperzine N, II, both products bearing an unusual decahydroquinoline stereostructure. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Synthetic Route of C6H12O2).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C6H12O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Effect of mixing methods of polyethylene and cellulose on volatile products from its co-pyrolysis was written by Sophonrat, Nanta;Yang, Weihong. And the article was included in Energy Procedia in 2017.Synthetic Route of C6H10O3 This article mentions the following:

Co-pyrolysis of biomass and plastic wastes is an alternative solution to produce fuel as well as to reduce environmental problem generated from municipal solid waste (MSW). Polyethylene (PE) and cellulose are the main compositions of waste packaging. To produce fuel from these two feedstocks by pyrolysis, the interaction/synergistic effect between them during pyrolysis should be studied. Due to that the interaction should be more pronounced if the two materials are in close contact, the mixing methods of the feedstocks can affect the product yield. In this work, the effect of mixing PE and cellulose on the volatile products from co-pyrolysis was investigated using Py-GC/MS with pyrolysis temperature of 600 °C. The different mixing methods used were, mixing by melting (cellulose powder submerged in PE film) and not mixing. The results showed that when PE and cellulose were not mixed the change in products were not significant, only slight increase in acetic acid was observed When mixed by melting, more oxygenated compounds were produced e.g. higher acetic acid, aliphatic ketones and some pyrans. However, the increases were small and does not significantly affect the main products which were aliphatic hydrocarbons from PE and levoglucosan from cellulose. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8Synthetic Route of C6H10O3).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C6H10O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Cascade radical reaction of substrates with a carbon-carbon triple bond as a radical acceptor was written by Miyabe, Hideto;Asada, Ryuta;Takemoto, Yoshiji. And the article was included in Beilstein Journal of Organic Chemistry in 2013.Quality Control of 2-Bromomethyl-1,3-dioxolane This article mentions the following:

The limitation of hydroxamate ester as a chiral Lewis acid coordination moiety was demonstrated in an intermol. reaction involving a radical addition and sequential allylation processes. Next, the effect of hydroxamate ester was studied in the cascade addition-cyclization-trapping reaction of substrates with a carbon-carbon triple bond as a radical acceptor. When substrates with a methacryloyl moiety and a carbon-carbon triple bond as two polarity-different radical acceptors were employed, the cascade reaction proceeded effectively. A high level of enantioselectivity was also obtained by a proper combination of chiral Lewis acid and these substrates. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Quality Control of 2-Bromomethyl-1,3-dioxolane).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Quality Control of 2-Bromomethyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Selective Oxidative Decarbonylative Cleavage of Unstrained C(sp³)-C(sp²) Bond: Synthesis of Substituted Benzoxazinones was written by Verma, Ajay;Kumar, Sangit. And the article was included in Organic Letters in 2016.Formula: C9H9NO3 This article mentions the following:

A transition metal (TM)-free practical synthesis of biol. relevant benzoxazinones has been established via a selective oxidative decarbonylative cleavage of an unstrained C(sp³)-C(sp²) bond employing iodine, sodium bicarbonate, and tert-Bu hydroperoxide in DMSO at 95 °C. Control experiments and D. Functional Theory (DFT) calculations suggest that the reaction involves a [1,5]H shift and extrusion of CO gas as the key steps. The extrusion of CO has also been established using PMA-PdCl₂. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Formula: C9H9NO3).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C9H9NO3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The synthesis of ketal catalyzed with H₃PW₁₂O₄₀ supported onto active carbon was written by Gao, Jin-zhang;Wei, Yun-xia;Wang, Xue-mei;Guo, Hao;Yang, Wu. And the article was included in Xibei Shifan Daxue Xuebao, Ziran Kexueban in 2006.Computed Properties of C6H12O2 This article mentions the following:

The behavior of H₃PW₁₂O₄₀ supported onto active carbon (HPW/C) is studied. The catalytic activity for the formation of ketal by using 2-butanone and ethylene glycol is also studied. The target compound thus prepared was 2-ethyl-2-methyl-1,3-dioxolane (2-butanone ethylene ketal). The results show that the yield of ketal is up to 67.3% by using the proposed catalyst, which is higher than that of using the unique H₃PW₁₂O₄₀. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Computed Properties of C6H12O2).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C6H12O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The chemistry of azocines. Intermediates for the synthesis of pyrrolizidines was written by Mariano, Patrick S.;Osborn, Morey E.;Dunaway-Mariano, Debra;Gunn, Brian C.;Pettersen, Roger C.. And the article was included in Journal of Organic Chemistry in 1977.Electric Literature of C6H11BrO2 This article mentions the following:

The preparation of 1,8-dihydro- and 1,6,7,8-tetrahydyroazocines lacking N substitution, and the use of transannular reaction of †4,5-epoxyhexahydroazocines for the generation of highly functionalized pyrrolizidines were described. 3,4-Dicarbomethoxy-1,8-dihydro- and 1,6,7,8-tetrahydroazocines (I and II) were prepared, starting from N-β-styryl-1,2-dihydropyridine and N-[2-[4-(bromomethyl)dioxolan-2-yl]ethyl]-1,2-dihydropyridine; methods using a variety of common N blocking groups were unsuccessful. In addition, procedures to convert azocines into functionalized pyrrolizidines, using transannular cyclization reactions, were explored. A high yielding sequence starting with the Δ4,5-epoxyhexahydroazocine III to give IV and proceeding through the intermediate bicyclic aminoether V (R = H) was developed. The structure of V (R = H) was determined by crystal structure studies of V (R = p-MeC6H4SO2). In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Electric Literature of C6H11BrO2).

2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Electric Literature of C6H11BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of butanone ethylene ketal with SO₄^2-/TiO₂-La₂O₃ was written by Bai, Ai-min;Du, Xin-xian;Yang, Shui-jin. And the article was included in Huagong Keji in 2007.Recommanded Product: 126-39-6 This article mentions the following:

Butanone ethylene ketal was synthesized from butanone and ethylene glycol in the presence of SO₄^2-/TiO₂-La₂O₃. The factors influencing the synthetic process were discussed and the best conditions were found out. The optimum conditions are: molar ratio of butanone to ethylene glycol is 1:2.0, the quantity of catalyst is equal to 0.50% of feed stocks, the reaction temperature is 79-89°C, and the reaction time is 2.0 h. SO₄^2-/TiO₂-La₂O₃ is an excellent catalyst. For synthesizing butanone ethylene ketal and its yield can reach over 58.1%. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Recommanded Product: 126-39-6).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 126-39-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Al-free Zr-beta zeolite as a selective catalyst for the ketalization of glycerol was written by Vannucci, Julian A.;Legnoverde, Maria S.;Dalla Costa, Bruno O.;Basaldella, Elena I.;Nichio, Nora N.;Pompeo, Francisco. And the article was included in Molecular Catalysis in 2022.Application of 100-79-8 This article mentions the following:

Two Zr-beta zeolites were synthesized using different methods. Method 1 consisted in the formation of a dealuminated zeolite beta seed followed by Zr incorporation and thermal treatment (ZBZr₁). In Method 2, zeolite beta was prepared and then, the dealumination and subsequent Zr incorporation were performed (ZBZr₂). These materials were tested in the ketalization of glycerol with acetone and compared with a SBAsulf. Both preparation methods incorporate Zr in the zeolitic framework, and no ZrO₂ is detected. Method 1 developed crystallites with an average size of 260 nm, Si/Zr ratio ∼100, total amount of acid sites of 0.375 mmol.g^-1 and a ratio of Bronsted to Lewis acid sites of 1.9. In the case of Method 2, values of 1500 nm, ∼86, 0.32 mmol.g^-1 and 0.7 were obtained, resp. The ZBZr₂ sample presented low catalytic activity, possibly due to diffusion limitations. The turnover frequency (TOF) was calculated as 44.84 and 60.37 min^-1 for ZBZr₁ and SBA_sulf , resp. After one cycle of reaction, both ZBZr₁ and SBA_sulf showed a decrease in the glycerol conversion, however, the selectivity remained constant in the ZBZr₁ material after the reaction cycle and the catalytic activity could be reestablished after a thermal treatment. In the experiment, the researchers used many compounds, for example, (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8Application of 100-79-8).

(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 100-79-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Fixation of carbon dioxide concurrently or in tandem with free radical polymerization for highly transparent polyacrylates with specific UV absorption was written by Liu, Bin;Zhang, Ying-Ying;Zhang, Xing-Hong;Du, Bin-Yang;Fan, Zhi-Qiang. And the article was included in Polymer Chemistry in 2016.Category: dioxole This article mentions the following:

It is still a challenging issue to combine the coupling reaction and free radical polymerization (FRP) for well-controlled and efficient synthesis of polyacrylates bearing the cyclic carbonate group from carbon dioxide (CO₂) and vinyl epoxides. This work describes the efficient catalytic synthesis of poly(2-oxo-1,3-dioxolane-4-yl)methyl methacrylate (PDOMA) from CO₂ and glycidyl methacrylate (GMA) via concurrent or tandem combination of the coupling reaction and FRP. In a concurrent reaction, GMA/CO₂ coupling with 100% oxirane conversion was achieved by using a nanolamellar zinc-cobalt (3) double metal cyanide complex [Zn-Co³⁺ DMCC] (0.30 mol% Zn related to GMA) with cetyltrimethylammonium bromide (0.65 mol% related to GMA) as the catalyst, and PDOMA was obtained via the concurrent free radical polymerization of carbon-carbon double bonds in the presence or absence of addnl. free radical initiator. In the tandem process, (2-oxo-1,3-dioxolane-4-yl)methyl methacrylate (DOMA) was firstly synthesized via GMA/CO₂ coupling catalyzed by Zn-Co(3) DMCC/CTAB and purified by simply passing through a basic aluminum oxide column. DOMA could be polymerized via solution or emulsion polymerization, leading to linear PDOMA or PDOMA nanoparticles with minimized metal residues. The obtained PDOMAs were soluble in strong polar solvents and presented excellent light transmittance in a wavelength range of 314-800 nm (93%) and perfect UV absorption in a wavelength range of 200-313 nm (close to 100%), while most of the common polyacrylates cannot absorb UV light. In addition, the PDOMAs had tunable number-average mol. weights (M_ns) of 12.0-132.0 kg mol^-1 and high glass transition temperatures (T_gs) of 121.0-140.4 °C. Such CO₂-based PDOMAs could be potentially used as wavelength-specific UV-absorbing materials. This work provides a simple and useful synthetic path to directly utilize CO₂ by combining two reaction mechanisms. In the experiment, the researchers used many compounds, for example, (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5Category: dioxole).

(2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem