Month: November 2022

On April 2, 1984, Yamamoto, Hiroshi; Harada, Masahiko; Inokawa, Saburo; Seo, Kuniaki; Armour, Margaret Ann; Nakashima, Thomas T. published an article.SDS of cas: 38838-06-1 The title of the article was Synthesis of 1,2,3,4-tetra-O-acetyl-5-deoxy-5-C-[(R)- and (S)-methoxyphosphinyl]-α- and -β-D-ribopyranoses. And the article contained the following:

Treatment of Me 5-deoxy-5-C-(diethoxyphosphinyl)-2,3-O-isopropylidene-β-D-ribofuranoside with Na dihydrobis(2-methoxyethoxy)aluminate, followed by H2O2, mineral acid, and H2O2, gave deoxy(hydroxyphosphinyl)ribopyranoses (I) in 40-45% overall yield. The structures of these sugar analogs were effectively established on the basis of the mass and 400-MHz, 1H-NMR spectra of the title compounds, derived by treatment with CH2N2 and then Ac2O in pyridine. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).SDS of cas: 38838-06-1

The Article related to phosphinylribopyranose, ribopyranose hydroxyphosphinyl, Carbohydrates: Monosaccharides, Glycals and other aspects.SDS of cas: 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On November 15, 1979, Garegg, Per J.; Samuelsson, Bertil published an article.Recommanded Product: 38838-06-1 The title of the article was Novel reagent system for converting a hydroxy group into an iodo group in carbohydrates with inversion of configuration. And the article contained the following:

Primary and secondary OH groups were converted into iodo groups, with inversion of configuration, by heating with Ph3P/iodine/imidazole (reagent A) or Ph3P/2,4,5-triiodoimidazole (reagent B) in PhMe at elevated temperature Iodine was introduced at the 2-position in hexopyranosides by these methods. E.g., Me 3,4,6-tri-O-benzyl-α-D-mannopyranoside gave 67 and 82% Me 3,4,6-tri-O-benzyl-2-deoxy-2-iodo-α-D-glucopyranoside by treatment with reagents A and B, resp. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Recommanded Product: 38838-06-1

The Article related to hydroxyl conversion iodo carbohydrate, iodination carbohydrate, Carbohydrates: Monosaccharides, Glycals and other aspects.Recommanded Product: 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Hampton, Alexander; Perini, Florian; Harper, Peter J. published an article in 1974, the title of the article was Derivatives of phosphonate and vinyl phosphate analogs of D-ribose 5-phosphate.SDS of cas: 38838-06-1 And the article contains the following content:

An isosteric α-keto phosphonate analog (I) of D-ribose 5-phosphate was prepared from Me 2,3-O-isopropylidene-β-D-ribofuranoside (II) by conversion of II via the 5-iodo and 5-cyano analogs into III, whose acid chloride reacted with (MeO)3P to give I. Attempts to prepare a β-keto phosphonate analog via the bromomethyl ketone (IV) gave instead the vinyl phosphate (V). The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).SDS of cas: 38838-06-1

The Article related to ribose phosphate analog, phosphonate ribose, phosphate vinyl ribose, Carbohydrates: Monosaccharides, Glycals and other aspects.SDS of cas: 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On September 30, 1979, Binkley, Roger W.; Hehemann, David G. published an article.Synthetic Route of 38838-06-1 The title of the article was Photolysis of deoxyiodo sugars. And the article contained the following:

Deoxyiodo sugars, prepared from the corresponding partially protected carbohydrates by the triflate displacement process, on photolysis for 3 h in Me2CHOH in the presence of NaHCO3 using 450-W medium pressure Hg lamp and a Corex filter gave the corresponding deoxy sugars in 72-100% yield. The choice of conditions for photolysis had a dramatic effect on the product yield, e.g., irradiation of I in MeOH using unfiltered light from an Hg lamp gave a mixture of products from which II was obtained in 32% yield, while irradiation in Me2CHOH and the use of Corex filter gave 100% II. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Synthetic Route of 38838-06-1

The Article related to photolysis iododeoxy sugar, deiodination iododeoxy sugar, deoxy sugar, Carbohydrates: Monosaccharides, Glycals and other aspects.Synthetic Route of 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Binkley, Roger W.; Hehemann, David G. published an article in 1978, the title of the article was New synthesis of deoxyiodo sugars.Recommanded Product: 38838-06-1 And the article contains the following content:

Five deoxyiodo sugars were synthesized by reaction of partially protected monosaccharides with (CF3SO2)2O to produce the corresponding triflate derivatives, which are converted to the deoxyiodo compounds by reaction with Bu4N+ I-. These reactions are convenient, with no competing elimination or rearrangement processes, and the product yields are 65-99%. This reaction sequence provides the first synthesis of 3-deoxy-3-iodo-1,2:5,6-di-O-isopropylidene-α-D-allofuranose (I). Previous attempts to synthesize I have resulted in rearrangement reactions. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Recommanded Product: 38838-06-1

The Article related to sugar deoxyiodo, iododeoxypentose, pentose iododeoxy, hexose iododeoxy, Carbohydrates: Monosaccharides, Glycals and other aspects.Recommanded Product: 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Araki, Younosuke; Endo, Tadatoshi; Tanji, Masaki; Arai, Yoshifusa; Ishido, Yoshiharu published an article in 1988, the title of the article was Synthesis of higher-carbon sugars by tributyltin hydride-azobisisobutyronitrile induced radical additions.Quality Control of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole And the article contains the following content:

The Bu3SnH-AIBN induced radical additions of 3,5-di-O-acetyl-6-deoxy-6-iodo-1,2-O-isopropylidene-α-D-gluco- and -allofuranose (I; R = OAc, R1 = H; R = H, R1 = OAc), and Me 5-deoxy-5-iodo-2,3-O-isopropylidene-β-D-ribofuranoside to di-Me maleate, Me acrylate, acrylonitrile, Me vinyl ketone, and vinylene carbonate gave various types of higher-carbon sugars. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Quality Control of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole

The Article related to higher carbon sugar, radical addition halofuranose, furanose halo radical addition, Carbohydrates: Monosaccharides, Glycals and other aspects.Quality Control of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Rychnovsky, Scott D.; Powers, Jay P. published an article in 2001, the title of the article was Zinc/copper couple.SDS of cas: 38838-06-1 And the article contains the following content:

Properties and applications of zinc/copper couple, an activated form of zinc metal reagent that can be used for cyclopropanation and conjugate addition of alkyl iodides to enones are reviewed. Also used for preparation of dichloroketene and 2-oxyallyl cations for cycloaddition reactions. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).SDS of cas: 38838-06-1

The Article related to review zinc copper couple preparation property reactivity, Organometallic and Organometalloidal Compounds: Reviews and other aspects.SDS of cas: 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On February 3, 2005, Fryszman, Olga M.; Lang, Hengyuan; Lan, Jiong; Chang, Edcon; Fang, Yunfeng published a patent.Application In Synthesis of Methyl 3-(1,3-dioxolan-2-yl)benzoate The title of the patent was Preparation of 5-membered heterocycles, in particular pyrazoles and imidazoles, as p38 kinase inhibitors. And the patent contained the following:

Title compounds I of [wherein R1 = H, acyl, P(:O)(OH)2; R2 = H, halo, (un)substituted alkyl, alkylthio, alkylsulfinyl, etc.; G = hetero/aryl, aralkyl, cycloalkyl, etc.; B = hetero/aryl; A = 5-membered ring containing one or two heteroatoms in the ring; D = CONH2 and derivatives, (un)substituted heteroaryl; R5 = H, halo, halo/thio/alkyl, OH and derivatives, alkyl/amino, etc.; R6 = H, halo, alkyl, alkoxy; and their pharmaceutically acceptable derivatives] were prepared as p38 kinase, including p38α and p38β kinase, inhibitors. Thus, reacting 3-hydrazino-N-methoxy-4-methylbenzamide with NaNO2 in the presence of SnCl2, and cyclization of the hydrazine with 2-(3-iodobenzoyl)-3-phenylaminoacrylonitrile gave II. Selected I displayed IC50 values <1 μM in a p38α kinase inhibition assay. I are useful for the treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, e.g. inflammatory disease, autoimmune disease, etc. The experimental process involved the reaction of Methyl 3-(1,3-dioxolan-2-yl)benzoate(cas: 124038-36-4).Application In Synthesis of Methyl 3-(1,3-dioxolan-2-yl)benzoate

The Article related to imidazole preparation p38 kinase inhibitor inflammation immunomodulator, antiinflammatory agent pyrazole preparation p38 kinase inhibition autoimmune disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application In Synthesis of Methyl 3-(1,3-dioxolan-2-yl)benzoate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On December 31, 2016, Ajay, Sama; Arora, Inderpreet; Saidhareddy, Puli; Shaw, Arun K. published an article.COA of Formula: C9H15IO4 The title of the article was Diversity-Oriented Synthesis of cis-3,4-Dihydroxylated Piperidine and Its Higher Saturated and Unsaturated Homologues from D-Ribose and Their Glycosidase-Inhibition Study. And the article contained the following:

The synthesis of six-, seven-, and eight-membered cis-dihydroxy azacycles has been accomplished from D-ribose using Vasella reductive amination as a key step and utilization of hydroboration-oxidation, Mitsunobu reaction, and ring-closing metathesis (RCM) reactions in a facile manner. These homologous dihydroxylated heterocyclic scaffolds were subjected to the glycosidase inhibition assays. However, only a moderate inhibitory activity for three out of five compounds was observed against α-glucosidases with a high degree of selectivity. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).COA of Formula: C9H15IO4

The Article related to cis dihydroxy azacycle preparation glycosidase inhibitor, ribose reductive amination hydroboration oxidation mitsunobu ring closing metathesis, Heterocyclic Compounds (One Hetero Atom): Higher-Membered Rings and other aspects.COA of Formula: C9H15IO4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On December 12, 2003, Verhelst, Steven H. L.; Martinez, Baltasar Paez; Timmer, Mattie S. M.; Lodder, Gerrit; Van der Marel, Gijsbert A.; Overkleeft, Herman S.; Van Boom, Jacques H. published an article.Synthetic Route of 38838-06-1 The title of the article was A Short Route toward Chiral, Polyhydroxylated Indolizidines and Quinolizidines. And the article contained the following:

In this paper, a rapid route toward functionalized bicyclic alkaloids is presented. In only three steps, an easily accessible carbohydrate derivative was converted into iodomethyl indolizidine I, which can equilibrate to the corresponding iodoquinolizidine II. We provide strong evidence that this equilibration proceeds via an aziridinium ion intermediate. Furthermore, nucleophilic substitution of the iodomethyl indolizidine as well as the aziridinium intermediate gives access to highly functionalized indolizidine and quinolizidine alkaloids. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Synthetic Route of 38838-06-1

The Article related to chiral polyhydroxylated indolizidine quinolizidine preparation, Alkaloids: Alkaloids Containing One Nitrogen Atom At A Bridgehead and other aspects.Synthetic Route of 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem