Month: November 2022

Shuqing, Wang published the artcileSynthesis of the vanillin 1,2 – propylene glycol acetal catalyzed by strong acid cation exchange resin, Category: dioxole, the publication is Jingxi Shiyou Huagong Jinzhan (2008), 9(7), 17-19, database is CAplus.

Vanillin 1,2-propylene glycol acetal was synthesized using 1,2-propylene glycol and vanillin as starting materials and strongly acidic cation exchange resin as catalyst. The effect of reaction temperature, reaction time, materials ratio, and the amounts of catalyst on the synthesis was studied, and the proper technol. conditions were given as follows: vanillin was 0.1mol, n(1,2-propanediol):n(vanillin) was 2.2; reaction temperature was 90-95°C, reaction time was 3.5 h, the amount of strongly acidic cation exchange resin was 1 g; and the water-carrying agent (cyclohexane) was 30 mL. The yield of vanillin 1,2-propylene glycol acetal can reach 84.86%. Purity of the vanillin 1,2-propylene glycol acetal is 98.5% and the catalysts can be used repeatedly.

Jingxi Shiyou Huagong Jinzhan published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C9H21NO3, Category: dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Zhong, Feng published the artcileConstruction of Chiral 2,3-Allenols through a Copper(I)-Catalyzed Asymmetric Direct Alkynylogous Aldol Reaction, Computed Properties of 503538-69-0, the publication is Angewandte Chemie, International Edition (2020), 59(4), 1562-1566, database is CAplus and MEDLINE.

Chiral 2,3-allenols were constructed through copper(I)-catalyzed asym. direct alkynylogous aldol reaction. With aromatic and heteroaromatic aldehydes, the alkynylogous aldol reaction with (R)-DTBM-SEGPHOS as the ligand proceeded smoothly to furnish the products in excellent regioselectivity with good to high diastereoselectivity and excellent enantioselectivity. In the cases of aliphatic aldehydes, esters of but-2-yn-1-ol as the substrates and (R,R)-Ph-BPE as the ligand are crucial to get good to high regio- and diastereoselectivity. The produced chiral 2,3-allenols are easily transformed into synthetically useful 2-furanones through cyclization. Finally, the developed method was successfully applied in the rapid synthesis of two chiral intermediates toward the synthesis of two pharmaceutically active compounds that are proposed for the treatment of neurol. disorders.

Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C19H21N3O3S, Computed Properties of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Peng, Fang published the artcileCatalytic application of H₄SiW₁₂O₄₀/TiO₂-SiO₂ in synthesis of acetals and ketals, Recommanded Product: 1,4-Dioxaspiro[4.5]decane, the publication is Applied Mechanics and Materials (2014), 320-325, database is CAplus.

The environmental friendly catalyst, H₃SiW₁₂O₄₀/TiO₂-SiO₂ was prepared by the impregnation method. The synthesis of cyclohexanone glycol ketal was as the probe reaction and investigated the different influences on the catalytic activity of H₄SiW₁₂O₄₀/TiO₂-SiO₂ by the quality of the carrier TiO₂-SiO₂ ratio, load of heteropoly acid, catalyst preparation conditions of the activation time and the calcination temperature, etc. The results showed the best condition for the preparation of the catalyst is the mass ratio of TiO₂ and SiO₂ is 1: 5, the load ratio of H₄SiW₁₂O₄₀ is 10 %, calcination temperature is 300 °C and the roasting time is 3.0 h. Under the condition of the molar ratio of aldehydes (ketones) and glycol (1,2-propanediol) is 1: 1.6, the mass percent of the catalyst is 1.4 %, and the reaction time of 70 min, the yields of eight kinds acetal (ketal) are 71.6 %∼ 90.5 %.

Applied Mechanics and Materials published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Recommanded Product: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Zhou, Yali published the artcileDevelopment of highly efficient platinum catalysts for hydroalkoxylation and hydroamination of unactivated alkenes, Product Details of C38H24F4O4P2, the publication is Nature Communications (2021), 12(1), 1953, database is CAplus and MEDLINE.

The design and discovery of “donor-acceptor”-type platinum catalysts that were highly effective in both hydroalkoxylation and hydroamination of unactivated alkenes over a broad range of substrates under mild conditions were described. A number of alkene substitution patterns were accommodated, including tri-substituted, 1,1-disubstituted, (E)-disubstituted, (Z)-disubstituted and even mono-substituted double bonds. Detailed mechanistic investigations suggested a plausible pathway that included an unexpected dissociation/re-association of the electron-deficient ligand to form an alkene-bound “donor-acceptor”-type intermediate. These mechanistic studies helped to understand the origins of the high reactivity exhibited by the catalytic system and provided a foundation for the rational design of chiral catalysts towards asym. hydrofunctionalization reactions.

Nature Communications published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C9H4F6O, Product Details of C38H24F4O4P2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Du, Yao published the artcileAsymmetric reductive Mannich reaction to ketimines catalyzed by a Cu(I) complex, Computed Properties of 503538-69-0, the publication is Journal of the American Chemical Society (2008), 130(48), 16146-16147, database is CAplus and MEDLINE.

A highly diastereoselective reductive Mannich coupling of ketimines and α,β-unsaturated esters was developed using CuOAc-PPh₃ or CuOAc-MePPh₂ complex as a catalyst (5 mol %) and pinacolborane as a reducing reagent. The reaction was easily conducted at room temperature, and the substrate generality was broad. This platform methodol. was extended to the first catalytic asym. reductive Mannich reaction of ketimines using CuOAc-DIFLUORPHOS as the catalyst (10 mol %). Switching the reducing reagent from pinacolborane to (EtO)₃SiH was key to inducing the high enantioselectivity (82-93% ee). High diastereoselectivity was also maintained (3:1∼30:1). Thus, products containing contiguous tetra- and trisubstituted carbons were catalytically synthesized with high stereoselectivities. Products were converted to α,β,β-trisubstituted (β^2,3,3) amino acid derivatives without any racemization and epimerization through simple treatment under acidic conditions. This method is the first entry of the catalytic asym. synthesis of β^2,3,3-amino acid derivatives, which constitute important chiral building blocks of biol. significant mols.

Journal of the American Chemical Society published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Computed Properties of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Wang, Hu published the artcileSynthesis of vanillin 1,2-propylene glycol acetal catalyzed by mesopore materials MCM-41 supported phosphotungstic acid hydrate, Application of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, the publication is Fenzi Kexue Xuebao (2012), 28(5), 432-436, database is CAplus.

Vanillin 1,2-propylene glycol acetal was synthesized using 1,2-propylene glycol and vanillin as starting materials, mesopore materials MCM-41 supported phosphotungstic acid hydrate as catalyst and cyclohexane as water stripping agent. Effects of factors on yield of product, such as molar ratio of the reactant, reaction time, the amount of water stripping agent and catalyst dosage and supported contents, were investigated. Exptl. results showed that the preferential conditions were as follows: the molar ratio of vanillin to 1,2-propylene glycol was 1:2.4; supported content was 50%, the dosage of catalyst was 2.0% of the total weight of the reactants; the amount of cyclohexane as water stripping agent was 15 mL; the reaction time was 2.0 h. Under these conditions, the yield can achieve 92%.

Fenzi Kexue Xuebao published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C6H10O3, Application of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Li, Sifeng published the artcilePalladium/Zinc Co-Catalyzed syn-Stereoselectively Asymmetric Ring-Opening Reaction of Oxabenzonorbornadienes with Phenols, Computed Properties of 503538-69-0, the publication is Chemistry – A European Journal (2015), 21(25), 9003-9007, database is CAplus and MEDLINE.

A new palladium/zinc co-catalyst system associated with chiral (R)-Difluorphos for asym. ring-opening reaction of oxabenzonorbornadienes with phenols is reported. This catalyst system allows the formation of cis-2-aryloxy-1,2-dihydronaphthalen-1-ol I (Ar = Ph, 4-FC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, etc.) and II (R = 5,8-(OCH₃)₂, 5,8-(CH₃)₂, 6,7-Br₂, 6,7-OCH₂O, 6,7-(OCH₃)₂) products in good yields (up to 95 % yield) with excellent enantioselectivities (up to 99 % ee). The cis-configuration of the product has been confirmed by X-ray crystal structure anal. To the best of our knowledge, it represents the first example in ring-opening reactions of bicycloalkenes with heteronucleophiles in a syn-stereoselective manner.

Chemistry – A European Journal published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Computed Properties of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Tu, Yuan-hong published the artcileSynthesis of vanillin 1,2-propylene glycol acetal catalyzed by silica supported ferric sulfate, SDS of cas: 68527-74-2, the publication is Riyong Huaxue Gongye (2008), 38(1), 39-41, database is CAplus.

Vanillin 1,2-propylene glycol acetal was synthesized using 1,2 -propylene glycol and vanillin as starting materials and silica supported ferric sulfate as catalyst. Effects of factors on yield of product, such as molar ratio of the reactants, reaction time, catalyst dosage and its stability, were investigated. Exptl. results showed that the preferential conditions were as follows: based on 0.1 mol of vanillin, the molar ratio of vanillin to 1,2 -propylene glycol was 1.0: 1.4; the dosage of catalyst was 2.5% of the total weight of the reactants; the amount of cyclohexane as water stripping agent was 12 mL; the reaction time was 3.0 h; under these conditions, the yield could achieve 86.0%.

Riyong Huaxue Gongye published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C6H10F3NO, SDS of cas: 68527-74-2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Shao, Lin-Jun published the artcileSynthesis of melamine-formaldehyde resin functionalized with sulfonic groups and its catalytic activities, HPLC of Formula: 177-10-6, the publication is Chemical Papers (2014), 68(7), 983-988, database is CAplus.

Spherical melamine-formaldehyde resin (MFR) particles were synthesized using the condensation reaction of melamine and formaldehyde with PEG-2000 as an additive. After thermal treatment at 200°C and then sulfonation by chlorosulphuric acid, an MFR-supported strong acid catalyst (SMFR) was prepared with an acidity of 3.23 mmol g^-1. This new acid catalyst was evaluated in the reactions of esterification and acetalization, with the results indicating that this novel acid catalyst was highly efficient in the traditional acid-catalyzed reaction. Its high activity, stability and reusability give it great potential for “green” chem. processes.

Chemical Papers published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C5H12O2, HPLC of Formula: 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem