Month: November 2022

Yang, Shuijin et al. published their research in Rare Metals (Beijing, China) in 2008 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Catalytic synthesis of acetals and ketals with H3PW12O40/PAn was written by Yang, Shuijin;Zhang, Yijun;Du, Xinxian;Merle, Philippe G.. And the article was included in Rare Metals (Beijing, China) in 2008.Category: dioxole The following contents are mentioned in the article:

A new environmental friendly catalyst H3PW12O40/PAn (PAn = polyaniline) was prepared and identified by means of FT-IR, XRD, and TG/DTA. The optimum conditions have been found; i.e., the mass ratio of PAn to H3PW12O40 is 1:1.5, the volume of methanol is 20 mL, and the reflux reaction time is 3 h. The structural identity of Keggin units is preserved after the incorporation into polyaniline matrix. Catalytic activities of H3PW12O40/PAn in synthesizing 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane, 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane, cyclohexanone ethylene ketal, cyclohexanone 1,2-propanediol ketal, butanone ethylene ketal, butanone 1,2-propanediol ketal, 2-phenyl-1,3-dioxolane, 4-methyl-2-phenyl-1,3-dioxolane, 2-propyl-1,3-dioxolane, and 4-methyl-2-propyl-1,3-dioxolane were reported. It has been demonstrated that H3PW12O40/PAn is an excellent catalyst. Various factors concerned in these reactions were investigated. The optimum conditions are as follows: the molar ratio of aldehyde/ketone to glycol (r) is 1:1.5, the mass ratio of the catalyst used to the reactants is 0.6%, and the reaction time is 1.0 h. Under these conditions, the yield is as follows: 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane, 69.0%; 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane, 79.5%; cyclohexanone ethylene ketal, 78.9%; cyclohexanone 1,2-propanediol ketal, 85.3%; butanone ethylene ketal, 56.9%; butanone 1,2-propanediol ketal, 78.1%; 2-phenyl-1,3-dioxolane, 76.3%; 4-methyl-2-phenyl-1,3-dioxolane, 94.2%; 2-propyl-1,3-dioxolane, 70.7%; and 4-methyl-2-propyl-1,3-dioxolane, 79.2%. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Category: dioxole).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Eshtiyaghi, Mahbobeh et al. published their research in Theriogenology in 2016 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Application of 6413-10-1

Royal jelly may improve the metabolism of glucose and redox state of ovine oocytes matured in vitro and embryonic development following in vitro fertilization was written by Eshtiyaghi, Mahbobeh;Deldar, Hamid;Pirsaraei, Zarbakht Ansari;Shohreh, Bahram. And the article was included in Theriogenology in 2016.Application of 6413-10-1 The following contents are mentioned in the article:

The aim of this study was to investigate the effect of different concentrations of royal jelly (RJ) on in vitro maturation (IVM), fertilization, cleavage, blastocyst rates, glutathione (GSH) content in ovine oocyte, mRNA abundance of antioxidant enzymes in both oocyte and cumulus, and glucose metabolism-related genes in cumulus cells. In vitro maturation of oocyte was performed in the presence of control (RJ0), 2.5 (RJ2.5), 5 (RJ5), and 10 (RJ10) mg/mL of RJ. Nuclear status, intracellular GSH content in oocytes, and mRNA abundance of selected genes were evaluated following 24 h of IVM. Following the IVM, fertilization and embryo culture were carried out in all the groups and embryonic development was examined The addition of 10-mg/mL RJ to maturation media not only yielded a higher number of oocytes at MII stage but also showed an increased level of intracellular GSH content than did RJ2.5 and control groups. Fertilization, cleavage, and blastocyst rate were higher in the RJ10 treatment group in comparison to the control one. In cumulus cells, the expression of PFKM, PFKL, and G6PDH were increased following the addition of RJ to the maturation media. Supplementation of 10-mg/mL RJ to IVM medium increased the GPx mRNA abundance in both oocyte and cumulus cells and SOD expression in the cumulus cells. The CAT mRNA abundance was not influenced by the addition of RJ to the maturation media in either oocyte or cumulus cells. It seems that the improvement of oocyte maturation and its subsequent development in RJ10 group may be associated with amelioration of redox status in the oocytes and activation of glucose metabolic pathways in their surrounding cumulus cells. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Application of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Application of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Tran, Quang Vinh et al. published their research in Journal of Porous Materials in 2020 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Preparation and testing of ceasium Bronsted ion-exchanged Al-SBA-15 supported heteropoly acid as heterogeneous catalyst in the fructone fragrancy synthesis was written by Tran, Quang Vinh;Truong, Thi Hanh;Hung, Tran Quang;Doan, Huan V.;Pham, Xuan Nui;Le, Nam Thi Hoai;Bach, Long Giang;Nguyen, Van Tuyen. And the article was included in Journal of Porous Materials in 2020.Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

Here we report a new ceasium Bronsted ion-exchanged Al-SBA-15 (Cs/AS15) supported heteropoly acid (HPA) H3PW12O40 (HPA-Cs/AS15) material which can be prepared and used as heterogeneous catalyst for the fructone fragrancy synthesis. It was demonstrated that Cs+ was more effective than NH4+ as counter cation of ion-exchanged AS15 support for preparing HPA/AS15 catalyst with higher acidity and HPA leaching stability. HPA-Cs/AS15 material showed high acidity with the maximum NH3 desorption peak appeared at 759.6°C in the NH3-TPD spectrum, stronger than pure HPA (635.7°C) and the ammonium Bronsted ion-exchanged Al-SBA-15 supported HPA (HPA-NH4/AS15) (559.1°C) materials. The HPA leaching stability test showed that the HPA content of HPA-Cs/AS15 catalyst reduced only by 2.55% after five washing times, much less than that of HPA-NH4/AS15 catalyst (49.22%). The higher acidity helped improve the HPA-Cs/AS15 catalyst performance in the fructone fragrancy synthesis. The Et acetoacetate conversion over this catalyst was 94.82%, better than those over HPA-NH4/AS15 (93.49%) and pure HPA (89.52%) catalysts, although HPA-Cs/AS15 catalyst had lower HPA content (23.16 wt%) than HPA-NH4/AS15 (24.28 wt%). In addition, it was shown that the reaction conditions such as Et acetoacetate:ethanediol reactant molar ratio of 1:1.5, ethanediol used as the diol reactant, and toluene used as the solvent, the fructone fragrancy synthesis reaction over HPA-Cs/AS15 catalyst reached the highest Et acetoacetate conversion (95.58%). The toluene’s boiling temperature of 110.6°C can promote the dispersion and contact abilities of the reactants with HPA mols. presented inside the pores of HPA-Cs/AS15 catalyst. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Shen, Chuanlei’s team published research in Nanjing Gongye Daxue Xuebao, Ziran Kexueban in 32 | CAS: 68527-74-2

Nanjing Gongye Daxue Xuebao, Ziran Kexueban published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C7H16ClNO2, Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol.

Shen, Chuanlei published the artcileCondensation reaction of vanillin with 1,2-propanediol over silica supported cesium phosphotungstate catalysts, Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, the publication is Nanjing Gongye Daxue Xuebao, Ziran Kexueban (2010), 32(2), 22-25, 30, database is CAplus.

A series of cesium phosphotungstate catalysts supported on silica gel (SiO2) were prepared and used to catalyze the condensation reaction of vanillin with 1,2-propanediol into vanillin propylene glycol acetal. The effects of substituted number of Cs+, loading of cesium phosphotungstate, catalyst amount, mole ratio of 1,2-propanediol to vanillin, and reaction time on the reactivity were investigated. Results showed that the catalyst with Cs+ substituted number of 2.5, and Cs salt loading of 40% exhibited the highest activity. Under optimal reaction conditions, i.e., reaction temperature 368 K, mole ratio of 1,2-propanediol to vanillin 2.4, catalyst mass fraction in reaction medium 1.5%, 30 mL benzene as water removal additive, and reaction time 3 h, the conversion of vanillin was 86.6% and the selectivity for vanillin propylene glycol acetal was 100%.

Nanjing Gongye Daxue Xuebao, Ziran Kexueban published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C7H16ClNO2, Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Tong, Shuo’s team published research in Angewandte Chemie, International Edition in 56 | CAS: 503538-69-0

Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C3H5F3O, Computed Properties of 503538-69-0.

Tong, Shuo published the artcileCatalytic Enantioselective Double Carbopalladation/C-H Functionalization with Statistical Amplification of Product Enantiopurity: A Convertible Linker Approach, Computed Properties of 503538-69-0, the publication is Angewandte Chemie, International Edition (2017), 56(45), 14192-14196, database is CAplus and MEDLINE.

Combining a catalytic enantioselective reaction with dimerization in a single operation is an efficient way to upgrade the enantiomeric excesses (ee) of the product. Palladium-catalyzed reaction of N-(2-iodophenyl)-N-Me methacrylamide derivatives with oxadiazole afforded, by a double enantioselective carbopalladation/intermol. heteroarene C-H alkylation sequence, homodimers I (R1 = H, 5-OMe, 5-Cl, 6-Cl, etc.; R2 = Me, Bn, i-Pr, etc.) in good yields with excellent ee values. The dimer was subsequently elaborated to the monomer in which the linker (oxadiazole) was incorporated into the target product.

Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C3H5F3O, Computed Properties of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Orlandi, Manuel’s team published research in Journal of Organic Chemistry in 85 | CAS: 503538-69-0

Journal of Organic Chemistry published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, COA of Formula: C38H24F4O4P2.

Orlandi, Manuel published the artcileComputational Analysis of Enantioselective Pd-Catalyzed α-Arylation of Ketones, COA of Formula: C38H24F4O4P2, the publication is Journal of Organic Chemistry (2020), 85(17), 11511-11518, database is CAplus and MEDLINE.

The direct α-arylation of carbonyl compounds emerged over the last two decades as a straightforward method for the formation of C(sp3)-C(sp2) bonds. Mechanistic studies suggested a classical cross-coupling catalytic cycle. This consists of oxidative addition of the aryl halide (ArX) to the Pd(0)-catalyst, transmetalation of the Na- or K-enolate generated in situ, and subsequent reductive elimination. Even though the general reaction mechanism was thoroughly investigated, studies focusing on enantioselective variants of this transformation are rare. Here, the computational study of the [Pd(BINAP)]-catalyzed α-arylation of 2-methyltetralone with bromobenzene is reported. The whole reaction energy profile was computed and several mechanistic scenarios were investigated for the key steps of the reaction, which are the enolate transmetalation and the C-C bond-forming reductive elimination. Among the computed mechanisms, the reductive elimination from the C-bound enolate Pd complex was found to be the most favorable one, providing a good match with the stereoselectivity observed exptl. with different ligands and substrates. Detailed anal. of the stereodetermining transition structures allowed us to establish the origin of the reaction enantioselectivity.

Journal of Organic Chemistry published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, COA of Formula: C38H24F4O4P2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Xu, Zhaohui’s team published research in Shipin Keji in | CAS: 68527-74-2

Shipin Keji published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C25H21N3O4, Recommanded Product: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol.

Xu, Zhaohui published the artcileSynthesis of 2-methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (vanillin 1,2-propylene glycol acetal) in presence of ferric potassium sulfate [FeK(SO4)2], Recommanded Product: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, the publication is Shipin Keji (2006), 176-178, database is CAplus.

The title compound, vanillin 1,2-propylene glycol acetal was synthesized from vanillin and 1,2-propylene glycol using ferric potassium sulfate as catalyst. The factors influencing the synthesis were discussed and the better reaction conditions were as follows: vanillin 0.1 mol, molar ratio of vanillin/1,2-propylene glycol 1.0/2.4 (mol/mol), the amount of catalyst 2.0% in proportion to the total reactant materials, the amount of benzene 16 mL, and reaction time 3.0 h. The product yield reached 86.0%.

Shipin Keji published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C25H21N3O4, Recommanded Product: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Lu, Yueqing’s team published research in Bulletin of Materials Science in 35 | CAS: 177-10-6

Bulletin of Materials Science published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Related Products of dioxole.

Lu, Yueqing published the artcileSynthesis of novel carbon/silica composites based strong acid catalyst and its catalytic activities for acetalization, Related Products of dioxole, the publication is Bulletin of Materials Science (2012), 35(3), 419-424, database is CAplus.

Novel solid acid based on carbon/silica composites are synthesized through one-pot hydrothermal carbonization of hydroxyethylsulfonic acid, sucrose and tetra-Et orthosilicate (TEOS). The novel solid acid owned the acidity of 20 mmol/g, much higher than that of the traditional solid acids such as Nafion and Amberlyst-15 (08 mmol/g). The catalytic activities of the solid acid are investigated through acetalization. The results showed that the novel solid acid was very efficient for the reactions. The high acidity and catalytic activities made the novel carbon/silica composites based solid acid hold great potential for the green chem. processes.

Bulletin of Materials Science published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Chen, Wen-long’s team published research in Guangzhou Huagong in 44 | CAS: 177-10-6

Guangzhou Huagong published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Application of 1,4-Dioxaspiro[4.5]decane.

Chen, Wen-long published the artcilePreparation and catalytic application of SO42-/SnO2-WO3/KIT-6 complex solid acid, Application of 1,4-Dioxaspiro[4.5]decane, the publication is Guangzhou Huagong (2016), 44(7), 1-4, database is CAplus.

Complex solid acid of SO42-/SnO2-WO3/KIT-6 was prepared through impregnation method using KIT-6 as template. The solid acid was used as catalyst for the Baeyer-Villiger oxidation of cyclic ketones and the condensation reaction between ketones/aldehyde and diols. It was found that the synthesized solid acid exhibited promising catalytic activity in the two kinds of reactions. The introducing of the WO3 and KIT-6 increased not only the acidity but also the specific area of the solid acid, therefore, the catalytic activity of the solid acid was enhanced.

Guangzhou Huagong published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Application of 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Tao, Duan-Jian’s team published research in Industrial & Engineering Chemistry Research in 51 | CAS: 177-10-6

Industrial & Engineering Chemistry Research published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H7NO4, Category: dioxole.

Tao, Duan-Jian published the artcileKinetics Study of the Ketalization Reaction of Cyclohexanone with Glycol Using Bronsted Acidic Ionic Liquids as Catalysts, Category: dioxole, the publication is Industrial & Engineering Chemistry Research (2012), 51(50), 16263-16269, database is CAplus.

It is remarkable that Bronsted acidic ionic liquids (BAILs) have several unique advantages in the acid-catalysis reaction, which avoids the tech. issues raised from mineral acids. The kinetics for the ketalization of cyclohexanone with glycol using BAILs as catalysts was therefore studied for the first time. The effects of various parameters such as kind of BAILs, temperature, catalyst loading, and molar ratio of the reactants on the conversion of cyclohexanone were examined in detail, and a pseudohomogeneous (PH) kinetic model was used successfully to correlate the exptl. data at from 313.15 to 343.15 K. The kinetic parameters such as reaction rate constant, activation energy, and chem. equilibrium constant then were proposed and utilized to interpret the catalytic activities of the BAILs catalysts. It was also validated from the comparison of catalytic performance among the BAILs, H2SO4, and solid resin that the BAILs were considered to be environmentally friendly and high efficient catalysts, and were suggested to replace mineral and solid acids in the synthesis of ketal.

Industrial & Engineering Chemistry Research published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H7NO4, Category: dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem