Day: April 23, 2021

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 54623-25-5, Name is 2,3,5-Tri-O-benzyl-D-ribose, molecular formula is C26H28O5. In an article, author is Meresi, G,once mentioned of 54623-25-5, Product Details of 54623-25-5.

Pulse field gradient NMR study of diffusion of pentane in amorphous glassy perfluorodioxole

Pulse field gradient diffusion measurements of pentane in a random copolymer of tetrafluoroethylene (TFE) and 2,2-bis(trifluoromethyl)-4,5-difluoro-1,3-dioxole (PDD) were made as a function of the time allowed for diffusion to occur. The initial change in echo amplitude at low values of q = gamma deltag was used to determine the apparent diffusion constant. The apparent diffusion constant determined in this way decreases to a constant value as time increases. At a time of 12.4 ms the apparent diffusion constant was 2.2 x 10(-7) cm(2) s(-1), and it decreases to 5.87 x 10(-8) cm(2) s(-1) at 1 s. This change in the apparent diffusion constant was interpreted in terms of morphological structure on the micron length scale in this completely amorphous glassy polymer. This polymer has been considered to have high free volume regions which lead to the observed rapid permeation of gases and vapors. These regions are interspersed in lower free volume regions, and the low free volume regions constitute the majority component. In the pulse field gradient NMR experiment, regions allowing for rapid diffusion interspersed with regions allowing only slow diffusion can lead to changes in the apparent diffusion constant as a function of diffusion time. The data observed in this system were compared with two simple models for the topology of the regions allowing for rapid diffusion: restricted diffusion and tortuous diffusion. The observed behavior is qualitatively similar to tortuous diffusion and can be fit with an equation describing this type of diffusion.

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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 51166-71-3, Name is 2,6-Di-O-methyl-β-cyclodextrin, molecular formula is C56H98O35. In an article, author is Alentiev, A. Yu.,once mentioned of 51166-71-3, Category: dioxoles.

Gas Permeation and Hemocompatibility of Novel Perfluorinated Polymers for Blood Oxygenation

Gas permeation properties of three highly permeable perfluorinated polymers (polyhexafluoropropylene (PHFP), amorphous Teflon AF2400, and polyperfluoro(2-methyl-2-ethyl-dioxole-1,3) (PPFMED)), which are promising materials for the dense thin layer of hollow fiber membranes for extracorporeal membrane oxygenation have been studied using nitrogen, oxygen, and carbon dioxide. Hemocompatibility of the polymeric films has also been investigated on whole blood from healthy donors. Gas permeation of the polymers increases in the order PHFP < PPFMEDD < AF2400, with PHFP alone having the permeability coefficients of the gases do not below those of polydimethylsiloxane applied as the selective layer of blood oxygenation membranes. Hemocompatibility of the polymers declines in the order PHFP > PPFMED > AF2400, with the most permeable polymer AF2400 exhibiting the worst hemocompatibility among the other polymers studied. Polyperfluoro(2-methyl-2-ethyl-dioxole-1,3) is shown to be the most appropriate polymer to fabricate hollow fiber membranes for blood oxygenation.

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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

In an article, author is JAHAN, MS, once mentioned the application of 43157-50-2, Name is 2-Thioadenosine, molecular formula is C10H13N5O4S, molecular weight is 299.3063, MDL number is MFCD00171540, category is dioxole. Now introduce a scientific discovery about this category, Name: 2-Thioadenosine.

EFFECT OF X-IRRADIATION ON OPTICAL-PROPERTIES OF TEFLON-AF

Radiation effects in optical-grade amorphous fluoropolymer, Teflon-AF, is investigated by UV-visible absorption and electron spin resonance (ESR) measurements. When irradiated with low-energy (40 kVp) X-rays at room temperature in air, Teflon-AF is found to develop a broad, structureless UV-absorption band in the wavelength interval 200-350 nm. While the UV absorption increases as a function of X-ray dose, with relative rates of approx 2 x 10(-5) Gy-1 (1 x 10(-5) Gy-1) in Teflon-AF 1600 (Teflon-AF 2400), its optical transparency for a given dose of 67.5 kGy, however, remains unaffected. Additional measurements conducted using electron spin resonance (ESR) technique reveal that the observed UV absorption is caused by the X-ray induced peroxy radical (POO.). The results also suggest that the inclusion of dioxole monomer in the PTFE chain not only improves the optical clarity of Teflon-AF, as reported, but also increases its radiation tolerance. During a post-irradiation storage in air at RT for about 30 days the peroxy radical is observed to decay, with a concomitant decrease in UV absorption. A tentative model is proposed to explain the radiation damage and recovery mechanisms.

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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C6H12O7, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 526-95-4, Name is Gluconic Acid (contains Gluconolactone), molecular formula is C6H12O7. In an article, author is Nijenhuis, Cynthia M.,once mentioned of 526-95-4.

Metabolite profiling of C-14-omacetaxine mepesuccinate in plasma and excreta of cancer patients

1. Omacetaxine mepesuccinate (hereafter referred to as omacetaxine) is a protein translation inhibitor approved by the US Food and Drug Administration for adult patients with chronic myeloid leukemia with resistance and/or intolerance to two or more tyrosine kinase inhibitors. 2. The objective was to investigate the metabolite profile of omacetaxine in plasma, urine and faeces samples collected up to 72h after a single 1.25-mg/m(2) subcutaneous dose of C-14-omacetaxine in cancer patients. 3. High-performance liquid chromatography mass spectrometry (MS) (high resolution) in combination with off-line radioactivity detection was used for metabolite identification. 4. In total, six metabolites of omacetaxine were detected. The reactions represented were mepesuccinate ester hydrolysis, methyl ester hydrolysis, pyrocatechol conversion from the 1,3-dioxole ring. Unchanged omacetaxine was the most prominent omacetaxine-related compound in plasma. In urine, unchanged omacetaxine was also dominant, together with 4′-DMHHT. In feces very little unchanged omacetaxine was found and the pyrocatechol metabolite of omacetaxine, M534 and 4′-desmethyl homoharringtonine (4′-DMHHT) was the most abundant metabolites. 5. Omacetaxine was extensively metabolized, with subsequent renal and hepatic elimination of the metabolites. The low levels of the metabolites found in plasma indicate that the metabolites are unlikely to contribute materially to the efficacy and/or toxicity of omacetaxine.

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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 144690-92-6, Name is Triphenyl methyl olmesartan, SMILES is O=C(C1=C(C(C)(O)C)N=C(CCC)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)C=C2)OCC8=C(C)OC(O8)=O, in an article , author is Duan, Yanwei, once mentioned of 144690-92-6, Computed Properties of C48H44N6O6.

Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine

Berberine is a traditional medicine that has multiple medicinal and agricultural applications. However, little is known about whether berberine can be a bioactive molecule toward carbohydrate-active enzymes, which play numerous vital roles in the life process. In this study, berberine and its analogs were discovered to be competitive inhibitors of glycoside hydrolase family 20 -N-acetyl-d-hexosaminidase (GH20 Hex) and GH18 chitinase from both humans and the insect pest Ostrinia furnacalis. Berberine and its analog SYSU-1 inhibit insect GH20 Hex from O. furnacalis (OfHex1), with K-i values of 12 and 8.5 m, respectively. Co-crystallization of berberine and its analog SYSU-1 in complex with OfHex1 revealed that the positively charged conjugate plane of berberine forms – stacking interactions with Trp(490), which are vital to its inhibitory activity. Moreover, the 1,3-dioxole group of berberine binds an unexplored pocket formed by Trp(322), Trp(483), and Val(484), which also contributes to its inhibitory activity. Berberine was also found to be an inhibitor of human GH20 Hex (HsHexB), human GH18 chitinase (HsCht and acidic mammalian chitinase), and insect GH18 chitinase (OfChtI). Besides GH18 and GH20 enzymes, berberine was shown to weakly inhibit human GH84 O-GlcNAcase (HsOGA) and Saccharomyces cerevisiae GH63 -glucosidase I (ScGluI). By analyzing the published crystal structures, berberine was revealed to bind with its targets in an identical mechanism, namely via – stacking and electrostatic interactions with the aromatic and acidic residues in the binding pockets. This paper reports new molecular targets of berberine and may provide a berberine-based scaffold for developing multitarget drugs.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 144690-92-6, you can contact me at any time and look forward to more communication. Computed Properties of C48H44N6O6.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem