So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Dong; Wang, Zhentao; Liu, Zhenlin; Huang, Mindong; Hu, Jianyong; Yu, Peng researched the compound: Methyl 5-fluoro-3-pyridinecarboxylate( cas:455-70-9 ).Computed Properties of C7H6FNO2.They published the article 《Strategic C-C Bond-Forming Dearomatization of Pyridines and Quinolines》 about this compound( cas:455-70-9 ) in Organic Letters. Keywords: regioselective diastereoselective tetrahydropyridine tetrahydroquinoline preparation one pot aromatization; dearomative double nucleophilic addition pyridine quinoline. We’ll tell you more about this compound (cas:455-70-9).
A one-pot protocol for the dearomative double nucleophilic addition to pyridines and quinolines, providing convenient, regioselective and diastereoselective access to tetrahydropyridines and tetrahydroquinolines under reductant-free conditions is described. This method also offers a new strategy for the general dearomatization of nitrogen heteroaromatics
This literature about this compound(455-70-9)Computed Properties of C7H6FNO2has given us a lot of inspiration, and I hope that the research on this compound(Methyl 5-fluoro-3-pyridinecarboxylate) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem