So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tarasova, O. A.; Nedolya, N. A.; Albanov, A. I.; Trofimov, B. A. researched the compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ).SDS of cas: 4360-63-8.They published the article 《Unexpected Formation of Thiophene in the Pyrrole Synthesis from Methoxyallene and Methyl Isothiocyanate》 about this compound( cas:4360-63-8 ) in Russian Journal of Organic Chemistry. Keywords: lithiated methoxyallene methyl isothiocyanate bromomethyl dioxolane copper cyclization; dioxolanylmethyl methoxythiophenamine preparation. We’ll tell you more about this compound (cas:4360-63-8).
The sequential reaction of lithiated methoxyallene, Me isothiocyanate, and 2-(bromomethyl)-1,3-dioxolane in the presence of CuBr yields a 2,3-disubstituted thiophene instead of the expected pyrrole. The process was accomplished in one preparative stage and involved intramol. cyclization of the in situ-generated lithium allenylimidothioate and N-alkylation of the resulting lithium thienylamide. Varying the reaction conditions did not affect its route: in all cases, the only product was N-(1,3-dioxolan-2-ylmethyl)-3-methoxy-N-methylthiophen-2-amine.
There is still a lot of research devoted to this compound(SMILES：BrCC1OCCO1)SDS of cas: 4360-63-8, and with the development of science, more effects of this compound(4360-63-8) can be discovered.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem