In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called C-H olefination of tryptophan residues in peptides: Control of residue selectivity and peptide-amino acid cross-linking, published in 2019-10-04, which mentions a compound: 7524-52-9, mainly applied to tryptophan peptide synthesis olefination solvent effect; peptide amino acid cross linking residue selectivity; protective group peptide coupling, Product Details of 7524-52-9.
There is high demand for new methods to modify peptides, for application in drug discovery and biomedicine. A C-H functionalization protocol for the olefination of tryptophan residues in peptides is described. The modification is successful for Trp residues at any position in the peptide, has broad scope in the styrene coupling partner, and offers opportunities for conjugating peptides with other biomols. For peptides containing both Trp and Phe, directing group manipulation enables full control of residue selectivity.
I hope my short article helps more people learn about this compound(H-Trp-OMe.HCl)Product Details of 7524-52-9. Apart from the compound(7524-52-9), you can read my other articles to know other related compounds.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem