Tag: M.W=250-300

Islam, Tofazzal Md. published the artcileHost-specific plant signal and G-protein activator, mastoparan, trigger differentiation of zoospores of the phytopathogenic oomycete Aphanomyces cochlioides, COA of Formula: C16H10O5, the publication is Plant and Soil (2003), 255(1), 131-142, database is CAplus.

We found that a gradient of a host-specific attractant, cochliophilin A (5-hydroxy-6,7-methylenedioxyflavone) isolated from the roots of spinach triggered encystment followed by germination of zoospores of Aphanomyces cochlioides at a concentration less than micromolar order. This compound did not affect the growth and reproduction of this phytopathogen up to 10^-6 M concentration in the culture medium. We also observed that mastoparan, an activator of heterotrimeric G-protein could inhibit the motility of zoospores and then strikingly effect encystment followed by 60-80% germination of cysts. Concomitant application of cochliophilin A and mastoparan showed stronger encystment followed by 100% germination of cysts. In addition, we have observed that chems. interfering with phospholipase C activity (neomycin) and Ca²⁺ influx/release (EGTA and loperamide) suppress cochliophilin A or mastoparan induced encystment and germination. These results suggest that G-protein mediated signal transduction mechanism may be involved in the differentiation of the A. cochlioides zoospores. This is the first report on the differentiation of oomycete zoospores initiated by a host-specific plant signal or a G-protein activator.

Plant and Soil published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, COA of Formula: C16H10O5.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Islam, Tofazzal Md. published the artcileMicroscopic studies on attachment and differentiation of zoospores of the phytopathogenic fungus Aphanomyces cochlioides, Safety of 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, the publication is Journal of General Plant Pathology (2002), 68(2), 111-117, database is CAplus.

The mode of aggregation, attachment and differentiation of zoospores of the phytopathogenic fungus Aphanomyces cochlioides when interacting with the host and a host-specific attractant and a G-protein activator, mastoparan, was studied by light and SEM. When a zoospore approached very close to the host root, it seemed to halt, then coiled its anterior flagellum on its body. The halted zoospore appeared to contact the host surface with its posterior flagellum, which gradually drew the encysting zoospore onto the root surface. The spore then docked precisely on the root surface at its ventral face with the help of the posterior flagellum and anchored itself by releasing some adhesive materials. The adherent spore became a spherical after shedding its flagella and rapidly turned into an expanded cyst forming a smooth cyst coat around it, and finally changed into a smaller cystospore covered with a wrinkled surface. In contrast, the mastoparan- or cochliophilin A-stimulated zoospores on artificial membranes aggregated by using their posterior flagella before encystment. These contrasting phenomena suggest that A. cochlioides zoospores may use their posterior flagella for successful docking on the host surface or for aggregation of encysting spores in the absence of the host.

Journal of General Plant Pathology published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, Safety of 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Wen, Yaolin published the artcilePhenolic constituents of Celosia cristata L. susceptible to spinach root rot pathogen Aphanomyces cochlioides, Related Products of dioxole, the publication is Bioscience, Biotechnology, and Biochemistry (2006), 70(10), 2567-2570, database is CAplus and MEDLINE.

Cochliophilin A (5-hydroxy-6,7-methylenedioxyflavone, 1), known as a host-specific attractant towards the zoospores of A. cochlioides, a cause of root rot and damping-off diseases of Chenopodiaceae, was found in the Amaranthaceae plant, Celosia cristata, that is susceptible to the pathogen. The content of 1 in Celosia seedlings was quantified as 1.4 μg/g fresh weight A new isoflavone, cristatein (5-hydroxy-6-hydroxymethyl-7,2′-dimethoxyisoflavone, 2), and five known flavonoids were also identified.

Bioscience, Biotechnology, and Biochemistry published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C9H7NO4, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Tahara, S. published the artcileSimple flavones possessing complex biological activity, Name: 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, the publication is Studies in Natural Products Chemistry (2000), 457-505, database is CAplus.

A review with 87 references Two simple flavones, each of which exhibits distinct biol. activity despite their closely related structures, have been recognized by detailed bioassays, and bioassay-oriented isolation procedures. The identity of both flavones has been confirmed by synthesis. One of these compounds, 5-methoxy-6,7-methylenedioxyflavone has been found in an extract of Polygonum lapathifolium L. subsp. nodosum (Polygonaceae) using a screening test devised to detect antidotes against the benzimidazole fungicide, benomyl (or its active principle MBC, 1H-benzimidazol-2-ylcarbamic acid Me ester). The other compound, 5-hydroxy-6,7-methylenedioxyflavone, is a host-specific signalling substance that exudes from spinach roots and attracts zoospores of the phytopathogenic fungus Aphanomyces cochlioides the cause of spinach root rot. This review describes the bioassay, isolation and identification of these active compounds, and compares their activity with that of various other related, and unrelated, chems. of either plant or synthetic origin. The possible ecochem. role and mode of action of flavone and non-flavone antidotes and attractants is briefly discussed.

Studies in Natural Products Chemistry published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C8H8O3, Name: 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Kikuchi, Hiroto published the artcileActivity of host-derived attractants and their related compounds toward the zoospores of phytopathogenic Aphanomyces cochlioides, Computed Properties of 110204-45-0, the publication is Bioscience, Biotechnology, and Biochemistry (1995), 59(11), 2033-5, database is CAplus.

Eleven flavones, including cochliophilin A and a chromone, were chem. prepared to determine the attracting activity for zoospores of Aphanomyces cochlioides, a causative fungus of spinach root rot. Analyses of the structure-activity relationship of each revealed a significant correlation between the zoospore attracting activity and the A-ring oxygenation at C-5 and C-7 in flavone skeleton. The relative attractancy of 4 regioisomers of N-trans-feruloyl 4-O-methyldopamine, which was identified as a zoospore attractant specific to another host plant Chenopodium album, was also examined

Bioscience, Biotechnology, and Biochemistry published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, Computed Properties of 110204-45-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Islam, Tofazzal Md. published the artcileInterruption of the homing events of phytopathogenic Aphanomyces cochlioides zoospores by secondary metabolites from nonhost Amaranthus gangeticus, Name: 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, the publication is Journal of Pesticide Science (Tokyo, Japan) (2004), 29(1), 6-14, database is CAplus.

On the screening of 200 nonhost plants, an Amaranthus gangeticus extract was found to attract and subsequently inhibit the motility of Aphanomyces cochlioides zoospores. The attractant was identified as N-trans-feruloyl-4-O-methyldopamine (I) and the motility inhibitor as nicotinamide (II) using bioassay-guided fractionation and spectroscopic methods. Also isolated were cochliophilin A and chondrillasterol 3-O-β-D-glucopyranoside. I had no inhibitory effect on zoospore motility whereas II immediately halted the motility and caused encystment in a dose-dependent manner (MIC, 5 × 10^-8 M). The cystospores produced by II regenerated zoospores instead of germinating. Concomitant application of I and II produced cystospores that germinated to give hyphae. TLC examinations revealed that A. gangeticus seedling exuded sufficient amounts of II from the roots. Exudation of II from A. gangeticus might be involved in its resistance against the soilborne oomycete phytopathogen A. cochlioides.

Journal of Pesticide Science (Tokyo, Japan) published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, Name: 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Wang, Jun-Fei published the artcileSynthesis of Ring A-Modified Baicalein Derivatives, Application of 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, the publication is Helvetica Chimica Acta (2011), 94(12), 2221-2230, database is CAplus.

Baicalein (5,6,7-trihydroxyflavone), an important active constituent of the traditional Chinese herb Scutellaria baicalensis, exhibited antitumor activity and inhibitory activity against P-gp 170. The syntheses of 25 baicalein derivatives are described here. These compounds were systematically modified with O-alkylation and O-acylation at HO-C(5), HO-C(6), and HO-C(7), singly or in combination, on the ring A of baicalein in order to evaluate the effects of such modifications on their inhibitory activities against multidrug-resistant tumor cell lines and P-gp 170 (no data). Highly selective and efficient alkylations at HO-C(7) of peracetylated baicalein were the key to the distinction between HO-C(6) and HO-C(7) of baicalein.

Helvetica Chimica Acta published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C13H11NO, Application of 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem