Tag: 200-300

Kim, Jack C. et al. published their research in Taehan Hwahakhoe Chi in 1988 | CAS: 3418-21-1

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 3418-21-1

A study of deketalization of rigid β-aminoketones was written by Kim, Jack C.;Lee, Yong Tae;Yoon, Ung Chan;Cho, In Seop;Moon, Sung Hwan;Han, Sun Hong. And the article was included in Taehan Hwahakhoe Chi in 1988.SDS of cas: 3418-21-1 This article mentions the following:

The causes of failure in the deketalization of rigid β-aminoketals were sep. investigated by examining the deketalization of ketals I (R = NH2, N+Me3, NHAc), and by examining the deketalization of non-rigid β-aminoketal 2-amino-1-ethylenedioxyacetophenone (II) and non-rigid aliphatic acetals R1CH(OMe)2 (III, R1 = NMe2, CH2NH2). While I (R = NH2, N+Me3) were not hydrolyzed in the various acidic conditions, I (R = NHAc) was easily deketalized. These results indicate the importance of electrostatic repulsion in the dicationic intermediates as a factor in the failure of deketalization. The easy deketalization of compounds II and III indicate that the structural characters of rigid β-aminoketals are also important factors in the hydrolysis of β-aminoketals. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1SDS of cas: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Hossein, Mahdavi et al. published their research in Chinese Journal of Chemistry in 2010 | CAS: 3418-21-1

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 3418-21-1

Synthesis and application of poly(diallyldimethylammonium tribromide) as a novel polymeric brominating agent was written by Hossein, Mahdavi;Zahra, Kachoei. And the article was included in Chinese Journal of Chemistry in 2010.Product Details of 3418-21-1 This article mentions the following:

In this study, the synthesis and applications of a new supported tribromide reagent is reported. This supported tribromide is used in α-bromoacetalization of ketones, bromination of alkenes and regioselective bromination of activated aromatic compounds This method is mild and no Br2 and HBr were used. Other advantages of this reagent are stability, high efficiency, simple filterability and reusability. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Product Details of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Elinson, M. N. et al. published their research in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1990 | CAS: 3418-21-1

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Anodic functionalization of alkenes in alcoholic medium in the presence of metal halides was written by Elinson, M. N.;Makhova, I. V.;Nikishin, G. I.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1990.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

The electrolysis of arylolefins in presence of alkali metal bromides led to formation of 1-aryl-2-bromo-ketals in alcs. The efficiency of the electrolysis was 60-90%. The 2-methyl-1-phenyl-1-propene formed 1-bromo-2-methyl-1-phenyl-1-propene with yield of 80%. Arylolefins without benzidine H atoms formed 1-aryl-1-alkoxy-2-bromoalkanes. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Rueping, Magnus et al. published their research in Synlett in 2011 | CAS: 3418-21-1

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 3418-21-1

Enantioselective synthesis of quinolizidines and indolizidines via a catalytic asymmetric hydrogenation cascade was written by Rueping, Magnus;Hubener, Lukas. And the article was included in Synlett in 2011.Recommanded Product: 3418-21-1 This article mentions the following:

A catalytic enantioselective synthesis of a new class of quinolizidines and indolizidines is presented. An asym. Bronsted acid catalyzed hydrogenation cascade as well as a sequential Bronsted acid/metal catalyzed hydrogenation protocol of 2-substituted quinolines yields benzofused quinolizidines and indolizidines in good yields with high diastereo- and enantioselectivities. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Roman, Gheorghe et al. published their research in ChemMedChem in 2010 | CAS: 3418-21-1

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Related Products of 3418-21-1

Heme Oxygenase Inhibition by 1-Aryl-2-(1H-imidazol-1-yl/1H-1,2,4-triazol-1-yl)ethanones and Their Derivatives was written by Roman, Gheorghe;Vlahakis, Jason Z.;Vukomanovic, Dragic;Nakatsu, Kanji;Szarek, Walter A.. And the article was included in ChemMedChem in 2010.Related Products of 3418-21-1 This article mentions the following:

Previous studies by our research group have been concerned with the design of selective inhibitors of heme oxygenases (HO-1 and HO-2). The majority of these were based on a four-carbon linkage of an azole, usually an imidazole, and an aromatic moiety. In the present study, we designed and synthesized a series of inhibition candidates containing a shorter linkage between these groups, specifically, a series of 1-aryl-2-(1H-imidazol-1-yl/1H-1,2,4-triazol-1-yl)ethanones and their derivatives As regards HO-1 inhibition, the aromatic moieties yielding best results were found to be halogen-substituted residues such as 3-bromophenyl, 4-bromophenyl, and 3,4-dichlorophenyl, or hydrocarbon residues such as 2-naphthyl, 4-biphenyl, 4-benzylphenyl, and 4-(2-phenethyl)phenyl. Among the imidazole-ketones, five (36-39, and 44) were found to be very potent (IC50<5 μM) toward both isoenzymes. Relative to the imidazole-ketones, the series of corresponding triazole-ketones showed four compounds (54, 55, 61, and 62) having a selectivity index >50 in favor of HO-1. In the case of the azole-dioxolanes, two of them (80 and 85), each possessing a 2-naphthyl moiety, were found to be particularly potent and selective HO-1 inhibitors. Three non-carbonyl analogs (87, 89, and 91) of 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethanone were found to be good inhibitors of HO-1. For the first time in our studies, two azole-based inhibitors (37 and 39) were found to exhibit a modest selectivity index in favor of HO-2. The present study has revealed addnl. candidates based on inhibition of heme oxygenases for potentially useful pharmacol. and therapeutic applications. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Related Products of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Related Products of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Savini, Luisa et al. published their research in Farmaco in 1993 | CAS: 50593-65-2

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C11H8ClNO2

Synthesis of 4-quinolylazide derivatives and evaluation of their antitumor and antimicrobial activity was written by Savini, Luisa;Massarelli, Paola;Pellerano, Cesare. And the article was included in Farmaco in 1993.Formula: C11H8ClNO2 The following contents are mentioned in the article:

Synthesis and pharmacol. evaluation of a series of 4-quinolylazide derivatives are reported. These were screened against P388 lymphocytic leukemia in mice, but they were inactive. All the compounds were also tested for their antimicrobial activity against gram-pos., gram-neg. strains and fungi; only three derivatives exhibited poor activity. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Formula: C11H8ClNO2).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C11H8ClNO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Gemma, Sandra et al. published their research in Tetrahedron Letters in 2008 | CAS: 50593-65-2

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Computed Properties of C11H8ClNO2

Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives was written by Gemma, Sandra;Kukreja, Gagan;Tripaldi, Pierangela;Altarelli, Maria;Bernetti, Matteo;Franceschini, Silvia;Savini, Luisa;Campiani, Giuseppe;Fattorusso, Caterina;Butini, Stefania. And the article was included in Tetrahedron Letters in 2008.Computed Properties of C11H8ClNO2 The following contents are mentioned in the article:

Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. This paper describes the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Computed Properties of C11H8ClNO2).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Computed Properties of C11H8ClNO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Brindisi, Margherita et al. published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2016 | CAS: 50593-65-2

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C11H8ClNO2

Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors was written by Brindisi, Margherita;Brogi, Simone;Giovani, Simone;Gemma, Sandra;Lamponi, Stefania;De Luca, Filomena;Novellino, Ettore;Campiani, Giuseppe;Docquier, Jean-Denis;Butini, Stefania. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2016.Computed Properties of C11H8ClNO2 The following contents are mentioned in the article:

Metallo-β-lactamases (MBLs) represent one of the most important and widespread mechanisms of resistance to β-lactam antibiotics (including the life-saving carbapenems), against which no clin. useful inhibitors are currently available. Here, the authors report a structure-based high-throughput docking campaign on 3 clin.-relevant acquired MBLs (IMP-1, NDM-1 and VIM-2). The initial hit, NF 1810, was optimized providing the broad-spectrum inhibitor , which was able to potentiate the in vitro activity of cefoxitin on a VIM-2-producing Escherichia coli strain. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Computed Properties of C11H8ClNO2).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C11H8ClNO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Pellerano, C. et al. published their research in Farmaco, Edizione Scientifica in 1984 | CAS: 50593-65-2

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Synthesis and biological activities of new compounds having a 1,3-dioxol[4,5-g]quinoline structure was written by Pellerano, C.;Savini, L.. And the article was included in Farmaco, Edizione Scientifica in 1984.Category: dioxole The following contents are mentioned in the article:

Four substituted 1,3-dioxol[4,5-g]quinolines (I; R = OH, Cl, SH or NHHN2) were prepared by heat cyclization of Et β–(3,4-methylenedioxyphenylamino)crotonate  [91918-88-6], followed by substitution of the R groups. By reaction of I (R = NHNH2) with a wide variety of carbonyl compounds, 26 corresponding hydrazones (II) were obtained. All the compounds were tested for antimicrobial activity in vitro and antitumor activity (P388 lymphocytic leukemia) in mice. Most II had good activity against gram-pos. bacteria but not against gram-neg. bacteria, fungi, or Trichomonas vaginalis. I and II were inactive against the tumor. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Category: dioxole).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Kakadiya, Rajesh et al. published their research in Bioorganic & Medicinal Chemistry in 2010 | CAS: 50593-65-2

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Safety of 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline

Potent DNA-directed alkylating agents: Synthesis and biological activity of phenyl N-mustard-quinoline conjugates having a urea or hydrazinecarboxamide linker was written by Kakadiya, Rajesh;Dong, Huajin;Kumar, Amit;Narsinh, Dodia;Zhang, Xiuguo;Chou, Ting-Chao;Lee, Te-Chang;Shah, Anamik;Su, Tsann-Long. And the article was included in Bioorganic & Medicinal Chemistry in 2010.Safety of 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline The following contents are mentioned in the article:

A series of N-mustard-quinoline conjugates bearing a urea or hydrazinecarboxamide linker was synthesized for antitumor evaluation. The in vitro cytotoxicity studies revealed that compounds with hydrazinecarboxamide linkers were generally more cytotoxic than the corresponding urea counterparts in inhibiting human lymphoblastic leukemia and various solid tumor cell growths in culture. The therapeutic efficacy against human tumor xenografts in animal model was studied. It was shown that complete tumor remission in nude mice bearing human breast carcinoma MX-1 xenograft by 17a, i and 18c, d was achieved. In the present study, it was revealed that both linkers are able to lower the chem. reactive N-mustard pharmacophore and thus the newly synthesized conjugates possess a long half-life in rat plasma. Moreover, the new N-mustard derivatives are able to induce DNA crosslinking either by modified comet assay or by alk. agarose gel shift assay. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Safety of 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Safety of 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem