Tag: 195.05

Enantioselective Aldehyde α-Nitroalkylation via Oxidative Organocatalysis was written by Wilson, Jonathan E.;Casarez, Anthony D.;MacMillan, David W. C.. And the article was included in Journal of the American Chemical Society in 2009.Related Products of 62563-07-9 This article mentions the following:

The first enantioselective organocatalytic α-nitroalkylation of aldehydes R¹CH₂CHO [R¹ = Me, n-Bu, cyclohexyl, PhCH₂O(CH₂)₃, PhCO₂(CH₂)₄, etc.] with silyl nitronates R²CH:N⁺(O^–)OSiR³₃ [R² = H, Me, Et, MeO₂CCH₂CH₂, cyclohexyl, etc.; SiR³₃ = SiMe₃, Si(i-Pr)₃, Si(t-Bu)Me₂, etc.] has been accomplished. The aforementioned process involves the oxidative coupling of an enamine intermediate, generated transiently via condensation of an amine catalyst with an aldehyde, with a silyl nitronate to produce a β-nitroaldehyde. Two methods, one that furnishes the syn β-nitroaldehyde and a second that provides access to the anti isomer, have been developed. Data are presented to support a hypothesis that explains this phenomenon in terms of a silyl group-controlled change in mechanism. Finally, a three-step procedure for the synthesis of both syn- and anti-α,β-disubstituted β-amino acids is presented. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Related Products of 62563-07-9).

2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Related Products of 62563-07-9

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Asymmetric synthesis and structural assignment of (-)-α-conhydrine was written by Enders, Dieter;Nolte, Bert;Raabe, Gerhard;Runsink, Jan. And the article was included in Tetrahedron: Asymmetry in 2002.Application In Synthesis of 2-(3-Bromopropyl)-1,3-dioxolane This article mentions the following:

The first asym. synthesis of the conium alkaloid (-)-α-conhydrine (I) is reported. Starting from a protected glycol aldehyde hydrazone as chiral precursor, a short route based on our α-alkylation/1,2-addition methodol. has been developed. After cleavage of the auxiliary and simultaneous deprotection, the concluding ring closure is accomplished under reductive amination conditions. The title compound is obtained in moderate overall yield and in excellent diastereo- and enantiomeric excess (d.e., e.e. >96%). Single-crystal x-ray crystallog. as well as ¹H NMR NOE experiments confirm the expected relative and absolute (2R,7S)-configuration of the product. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Application In Synthesis of 2-(3-Bromopropyl)-1,3-dioxolane).

2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-(3-Bromopropyl)-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A Novel Palladium-Catalyzed Arylation-Dehydroaromatization Reaction: Synthesis of 7-Aryltetralones was written by Varseev, Georgy N.;Maier, Martin E.. And the article was included in Organic Letters in 2005.Application of 62563-07-9 This article mentions the following:

A new one-pot room-temperature palladium-catalyzed synthesis of 7-aryltetralones was discovered. This tandem process includes a palladium-catalyzed γ-selective arylation of enone I by aryl bromides or iodides followed by a dehydrogenation-aromatization of the initial cross-coupling product. E.g., Pd(OAc)₂/PPh₃-catalyzed arylation of enone I by BrPh gave 71% 7-phenyl-1-tetralone. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Application of 62563-07-9).

2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application of 62563-07-9

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Nickel-Catalyzed Asymmetric Reductive Arylalkylation of Unactivated Alkenes was written by Jin, Youxiang;Wang, Chuan. And the article was included in Angewandte Chemie, International Edition in 2019.Recommanded Product: 2-(3-Bromopropyl)-1,3-dioxolane This article mentions the following:

Reported is an asym. reductive dicarbofunctionalization of unactivated alkenes [e.g., 1-bromo-2-(3-methylbut-3-en-1-yl)benzene + 4-bromobutyl acetate → I (69%, 94% ee)]. Under the catalysis of a Ni/BOX system, various aryl bromides, incorporating a pendant olefinic unit, were successfully reacted with an array of primary alkyl bromides in the presence of Zn as a reductant, furnishing a series of benzene-fused cyclic compounds bearing a quaternary stereocenter in high enantioselectivities. Notably, this reaction avoids the use of pregenerated organometallics and demonstrates high tolerance of sensitive functionalities. The preliminary mechanistic investigations reveal that this Ni-catalyzed reaction proceeds as a cascade consisting of migratory insertion and cross-coupling with a nickel(I)-mediated intramol. 5-exo cyclization as the enantiodetermining step. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Recommanded Product: 2-(3-Bromopropyl)-1,3-dioxolane).

2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 2-(3-Bromopropyl)-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem