Asymmetric synthesis and structural assignment of (-)-α-conhydrine was written by Enders, Dieter;Nolte, Bert;Raabe, Gerhard;Runsink, Jan. And the article was included in Tetrahedron: Asymmetry in 2002.Application In Synthesis of 2-(3-Bromopropyl)-1,3-dioxolane This article mentions the following:
The first asym. synthesis of the conium alkaloid (-)-α-conhydrine (I) is reported. Starting from a protected glycol aldehyde hydrazone as chiral precursor, a short route based on our α-alkylation/1,2-addition methodol. has been developed. After cleavage of the auxiliary and simultaneous deprotection, the concluding ring closure is accomplished under reductive amination conditions. The title compound is obtained in moderate overall yield and in excellent diastereo- and enantiomeric excess (d.e., e.e. >96%). Single-crystal x-ray crystallog. as well as 1H NMR NOE experiments confirm the expected relative and absolute (2R,7S)-configuration of the product. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Application In Synthesis of 2-(3-Bromopropyl)-1,3-dioxolane).
2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-(3-Bromopropyl)-1,3-dioxolane
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem