Tag: 122.55

Synthesis of N-Substituted (2,3-Dihydro-1,4-Benzodioxin-6-YL)Benzenesulfonamide Derivatives as Potent Antibacterial Agents and Moderate Enzyme Inhibitors was written by Abbasi, M. A.;Farani, S. K.;Aziz-ur-Rehman;Siddiqui, S. Z.;Ahmad, I.;Malik, R.;Ashraf, M.;Qurat-ul-Ain. And the article was included in Pharmaceutical Chemistry Journal in 2017.Application In Synthesis of 2-Chloromethyl-1,3-dioxolane This article mentions the following:

The present research work involved the reaction of 2,3-dihydro-1,4-benzodioxin-6-amine and benzenesulfonyl chloride under dynamic pH control at 10 using aqueous Na₂CO₃. This reaction yielded (2,3-dihydro-1,4-benzodioxin-6-yl)benzenesulfonamide , which was further substituted at N-position with various alkyl/aryl halides in N,N-dimethylformamide and catalytic amount of lithium hydride to obtain N-substituted (2,3-dihydro-1,4-benzodioxin-6-yl)benzenesulfonamides. The projected structures of the synthesized derivatives were confirmed using various spectral techniques (IR, 1H NMR and EIMS). The synthesized derivatives were screened for antibacterial potential and inhibitory activity against lipoxygenase enzyme. In the experiment, the researchers used many compounds, for example, 2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1Application In Synthesis of 2-Chloromethyl-1,3-dioxolane).

2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Application In Synthesis of 2-Chloromethyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Applications of phase transfer catalysis. II. Synthesis of 2-(dihalomethyl)-1,3-dioxolanes and 2-(dihalomethyl)-1,3-dioxanes was written by Steinbeck, Karl. And the article was included in Chemische Berichte in 1979.Computed Properties of C4H7ClO2 This article mentions the following:

(Halomethyl)dioxolanes I (n = 1, R = H, optionally substituted alkyl, Ph, R¹ = Cl) (34 compounds), I (n = 1, R = H, Me, Pr, CHMe₂, Bu, hexyl, Ph, 4-MeOC₆H₄, R¹ = Br) and dioxanes I (n = 2, R = H, Me, Pr, CHMe₂, Bu, hexyl, Ph, 4-MeOC₆H₄, R¹ = Cl) were prepared by C-H insertion reactions of dihalocarbenes generated by phase transfer catalysis; I were free of isomeric by-products. Electron-attracting substituents (R) decreased the yield in the reaction. The reactivity of the dioxanes was much lower than that of the dioxolanes. In the experiment, the researchers used many compounds, for example, 2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1Computed Properties of C4H7ClO2).

2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C4H7ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation of racemic and enantiomerically pure cyclic ketene acetals was written by Diaz-Ortiz, A.;Diez-Barra, E.;de la Hoz, A.;Prieto, P.. And the article was included in Synthetic Communications in 1993.Product Details of 2568-30-1 This article mentions the following:

Cyclic ketene acetals have been prepared from α-haloaldehyde di-Me acetals by transacetalization and subsequent elimination in PTC without solvent conditions. No racemization has been observed when an enantiomerically pure diol has been used. Stability and storage conditions have been studied. Thus, cyclocondensation of XCH₂CH(OR) (R = Me, X = Cl, Br) with diols gave 77-93% cyclic acetals which underwent dehydrohalogenation with KOH-Bu₄N⁺ Br^– to give cyclic ketene acetals, e.g. I–III. In the experiment, the researchers used many compounds, for example, 2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1Product Details of 2568-30-1).

2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 2568-30-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

New aromatic azobis ethers obtained by condensation of sodium 4,4′-azodiphenoxide with monochloromethylated derivatives was written by Radu, Stelian;Borrell, Jose Ignacio;Gassiot i Matas, Miquel. And the article was included in Afinidad in 1995.Reference of 2568-30-1 This article mentions the following:

Seven new aromatic azobis ethers were synthesized by condensation of the sodium salt of 4,4′-dihydroxyazobenzene with following monochloromethylated derivatives: 1-chloro-2-(chloromethyl)benzene, 1-chloro-3-(chloromethyl)benzene, 1-chloro-4-(chloromethyl)benzene, 1-(chloromethyl)naphthalene, 2-(chloromethyl)-1H-isoindole-1,3(2H)dione, 2-chloromethyl-1,3-dioxolane and diphenylchloromethane. Behavior as liquid crystals was not detected for these compounds In the experiment, the researchers used many compounds, for example, 2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1Reference of 2568-30-1).

2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Reference of 2568-30-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Reactions relating to carbohydrates and polysaccharides. XLIV. Synthesis of isomeric bicyclic acetal ethers was written by Hallonquist, E. G.;Hibbert, H.. And the article was included in Canadian Journal of Research in 1933.Computed Properties of C4H7ClO2 This article mentions the following:

3,5,7-Trioxabicyclo[2.2.2]octane (I), m. 99° and of high vapor pressure, results in 95% yield by the action of aqueous KOH at 100° on 1,3-bromoethylideneglycerol 2-benzoate ( Acid hydrolysis of I gives HOCH₂CHO and glycerol, hydrolysis at the acetal ether linkages taking place simultaneously. Glycerol α-benzoate (II), prepared in 98% yield (Fischer, Bergmann and Barwind, C. A. 15, 684), treated with tribromoparaldehyde gives 1,2-bromoethylideneglycerol 3-benzoate (III). III with aqueous KOH gives 3,6,8-trioxabicyclo[3.2.1]octane (IV), m. 56-7° and of high vapor pressure. III in this reaction compared with its isomer is fairly inert. IV on hydrolysis gives HOCH₂CHO and glycerol. I and IV show no indication of interconvertibility on solution in solvents or under the influence of heat (Haskelberg, C. A. 26, 3777). Glycerol (30 g.) and ClCH₂CH(OEt)₂ (50 g.), heated with stirring at 115° for 15 min., gave on distilling chloroethylideneglycerol, b₁₃, 130-4°, in 80% yield. Similarly there was prepared chloroethylideneglycol, b₁₃ 57°, chloroethylidenetrimethylene glycol, b₁₁ 60-2°, β-chloropropylideneglycerol, b₁₅ 129-35°, and β-bromopropylideneglycerol, b₁₈ 136-40°, in yields of 40, 60, 56 and 65%, resp. The application of this method to the synthesis of cyclic acetals from open-chain acetals is being used in the determination of the structure of carbohydrates and polysaccharides. In the experiment, the researchers used many compounds, for example, 2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1Computed Properties of C4H7ClO2).

2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C4H7ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem