144690-92-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Triphenyl methyl olmesartan, cas is 144690-92-6,the Dioxole compound, it is a common compound, a new synthetic route is introduced below.
21.6 g of triethylolmethane-containing methoxycinnamic acid (formula 1a), 3 g of hydroxylamine hydrochloride, 14 mL of acetone and 70 mL of ethanol were added to the reaction part, followed by stirring at 25 to 40 C for 4 hours. When the reaction was completed, the reaction solution was concentrated under reduced pressure. Ethyl acetate (80 mL) was added to the residue, and the mixture was stirred for 3 hours to precipitate crystals. The precipitated crystals were stirred at 20 to 25 C for 2 hours, filtered and washed with 20 mL of purified water. To the filtrate was added 40 mL of ethyl acetate, the temperature was cooled to 0 to 5 C, The pH of the filtrate was adjusted to pH 5.0 to 6.0 by adding 45 g of triethylamine to the filtrate, and crystals were slowly precipitated. The precipitated crystals were stirred at 0 to 5 C for 3 hours, filtered, washed with 30 mL of purified water and 30 mL of acetone, and dried under reduced pressure for 15 hours to obtain 12.3 g (yield 82%, purity 99.96%) of olmesartan methoxysilane (Formula 1b).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Triphenyl methyl olmesartan, 144690-92-6
Reference£º
Patent; DONGBANG FTL CO., LTD; Song, Tae Hong; Jung, Hun Suk; Jang, Do Yeon; Moon, Chung Sun; Jung, Hee Jung; (18 pag.)KR101526249; (2015); B1;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem