Dioxole related

Wadamoto, Manabu published the artcileStereochemical Studies of Ag-Catalyzed Hosomi-Sakurai Reaction Using Chiral Silanes, Related Products of dioxole, the publication is European Journal of Organic Chemistry (2009), 5132-5133, database is CAplus and MEDLINE.

Stereochem. aspect of asym. Ag-catalyzed Hosomi-Sakurai reaction with ketones was studied. Several allyltrimethoxysilanes were synthesized and used for the asym. reaction. Remarkably, among several possible diastereomers only two are generated with high levels of diastereo- and enantioselectivities. Based on the observations for different allyltrimethoxysilanes, the authors hypothesize formation of a single allylsilver species which undergoes addition to the ketone.(© KGaA, 69451 Weinheim, Germany, 2009). Wiley-VCH Verlag GmbH and Co.

European Journal of Organic Chemistry published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C14H23N, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Kanai, Shunsuke published the artcileA bifunctional cerium phosphate catalyst for chemoselective acetalization, Recommanded Product: 1,4-Dioxaspiro[4.5]decane, the publication is Chemical Science (2017), 8(4), 3146-3153, database is CAplus and MEDLINE.

In this study, a CePO₄ catalyst was synthesized using a hydrothermal method and found to exhibit high catalytic performance for the chemoselective acetalization of 5-hydroxymethylfurfural with alcs., in sharp contrast to other homogeneous and heterogeneous acid and/or base catalysts. In the presence of CePO₄, various combinations of carbonyl compounds and alcs. are efficiently converted into the corresponding acetal derivatives in good to excellent yields. Mechanistic studies show that CePO₄ most likely acts as a bifunctional catalyst through the interaction of uniform Lewis acid and weak base sites with 5-hydroxymethylfurfural and alc. mols., resp., which results in high catalytic performance.

Chemical Science published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Recommanded Product: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Lamb, Thomas published the artcilePod-based menthol and tobacco flavored e-cigarettes cause mitochondrial dysfunction in lung epithelial cells, HPLC of Formula: 1193-11-9, the publication is Toxicology Letters (2020), 303-311, database is CAplus and MEDLINE.

Current FDA regulations have resulted in a ban of flavored e-cigarette pods, with only menthol and tobacco flavored pods being exempted. Previous work using menthol and tobacco-flavored e-cigarettes have been shown to induce mitochondrial reactive oxygen species. We hypothesized that exposure to pod-based JUUL Menthol and Virginia Tobacco aerosols will alter mitochondrial respiration and electron transport chain protein levels. We determined mitochondrial respiration by using a Seahorse technique and electron transport chain complexes by total OXPHOS antibodies after exposing lung epithelial cells, Beas-2b, to pod-based Menthol and Virginia Tobacco flavored aerosols. Menthol pod exposure resulted in an immediate increase in proton leak and decrease in coupling efficiency, as well as a decrease in complex I, II, and IV. Menthol pod exposure twenty-four hour post-exposure resulted in a decrease in basal respiration, maximal respiration, and spare capacity, as well as a decrease in complex I. Tobacco pod exposure resulted in no significant alterations to mitochondrial respiration, but immediately post final exposure resulted in a significant increase in complex I, IV, and V. Our results indicate that exposure to Menthol flavored e-cigarette pods cause mitochondrial dysfunction in lung epithelial cells.

Toxicology Letters published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, HPLC of Formula: 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Ween, M. P. published the artcileE-cigarettes and health risks: more to the flavor than just the name, Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, the publication is American Journal of Physiology (2021), 320(4), L600-L614, database is CAplus and MEDLINE.

The growing interest in regulating flavored E-liquids must incorporate understanding of the “flavoring profile” of each E-liquid-which flavorings (flavoring chems.) are present and at what concentrations not just focusing on the flavor on the label. We investigated the flavoring profile of 10 different flavored E-liquids We assessed bronchial epithelial cell viability and apoptosis, phagocytosis of bacteria and apoptotic cells by macrophages after exposure to E-cigarette vapor extract (EVE). We validated our data in normal human bronchial epithelial cells (NHBE) and alveolar macrophages (AM) from healthy donors. We also assessed cytokine release and validated in the saliva from E-cigarette users. Increased necrosis/apoptosis (16.1-64.5% apoptosis) in 16HBE cells was flavor dependent, and NHBEs showed an increased susceptibility to flavors. In THP-1 differentiated macrophages phagocytosis was also flavor dependent, with AM also showing increased susceptibility to flavors. Further, Banana and Chocolate were shown to reduce surface expression of phagocytic target recognition receptors on alveolar macrophages. Banana and Chocolate increased IL-8 secretion by NHBE, whereas all 4 flavors reduced AM IL-1β secretion, which was also reduced in the saliva of E-cigarette users compared with healthy controls. Flavorant profiles of E-liquids varied from simple 2 compound mixtures to complex mixtures containing over a dozen flavorants. E-liquids with high benzene content, complex flavoring profiles, high chem. concentration had the greatest impacts. The Flavorant profile of E-liquids is key to disruption of the airway status quo by increasing bronchial epithelial cell apoptosis, causing alveolar macrophage phagocytic dysfunction, and altering airway cytokines.

American Journal of Physiology published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C5H5NO3S, Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Ikeda, Keiichi published the artcileRh(I)-Catalyzed cyclocarbonylation of enynes with glyceraldehyde: an available carbonyl source derived from sugar alcohols, Name: 1,4-Dioxaspiro[4.5]decane, the publication is Synlett (2012), 23(3), 393-396, database is CAplus.

Catalytic cyclocarbonylation reactions using a glyceraldehyde derivative as a carbonyl source are described. The rhodium(I)-catalyzed reaction of enynes, e.g., H₂C:CHCH₂OCH₂CCR ( R = Ph, n-Bu, CMe₃), with glyceraldehyde acetonide I gave bicyclic cyclopentenones, e.g., II, as the products. This presents an interesting use of a sugar alc. derived carbon resource as well as a convenient procedure for the cyclocarbonylation of enynes.

Synlett published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Name: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Bucsi, Imre published the artcileTransformation of 1,2-diols over perfluorinated resinsulfonic acids (Nafion-H), Computed Properties of 1193-11-9, the publication is Tetrahedron (1994), 50(27), 8195-202, database is CAplus.

The transformations of 1,2-diols over perfluorinated resinsulfonic acids (Nafion-H) were studied and correlations were examined between the structures of the investigated diols, the possible dehydration routes and the catalytic properties of Nafion-H. Comparisons were also made between the catalytic properties of Nafion-H and NaHX zeolite. Because of its stronger acidity, Nafion-H functions at temperatures considerably lower than those for the usual dehydrating catalysts, e.g., the zeolites. As is well established for other solid electrophilic catalysts, the dehydration of 1,2-diols mainly proceeds via the pinacol rearrangement. The lower temperatures and the stronger acidity of Nafion-H strongly favor the pinacol rearrangement vs. 1,2-elimination. The reaction conditions are also advantageous for the formation of substituted 1,3-dioxolanes in a secondary condensation step between the unreacted diol and the primarily formed carbonyl compounds Nafion-H gradually deactivates during long use, but it can be partially reactivated by washing with acetone.

Tetrahedron published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Computed Properties of 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Beresnevich, L. B. published the artcileSynthesis of 1,3-dioxolanes from natural carbonyl compounds, Computed Properties of 68527-74-2, the publication is Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk (2009), 73-76, database is CAplus.

Condensation of various naturally occurring aldehydes and ketones R¹R²CO [R¹ = H, R² = n-Pr, i-Bu, 4-MeC₆H₄CH₂CHMe, 4-HO-3-MeOC₆H₃, etc.; R¹R² = (CH₂)₄, (CH₂)₅, etc.; R¹ = R² = n-Pr; R¹ = Me, R² = Et, t-Bu, n-hexyl] with 1,2-propanediol in the presence of sulfonated cationite FIBAN K-1 neat or in benzene gave the corresponding 1,3-dioxolanes in 50-98% yields.

Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, Computed Properties of 68527-74-2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Tahara, Satoshi published the artcilePlant secondary metabolites regulating behavior of zoospores of the phytopathogenic fungus Aphanomyces cochlioides, HPLC of Formula: 110204-45-0, the publication is Pesticide Science (1999), 55(2), 209-211, database is CAplus.

A number of compounds isolated from various plant species were tested for their ability to affect the mobility of zoospores of A. cochlioides which causes root rot in spinach (Spinacia oleracea). Compounds may act as attractants, repellents or stimulants of zoospore movement or they may halt movement by causing the spore to clump and settle. Bioassays revealed compounds with these modes of action, as well as some which acted directly on the fungus.

Pesticide Science published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C12H14IN, HPLC of Formula: 110204-45-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Takayama, Tomohiko published the artcileDrop method as a quantitative bioassay method of chemotaxis of Aphanomyces cochlioides zoospore, Product Details of C16H10O5, the publication is Nippon Shokubutsu Byori Gakkaiho (1998), 64(3), 175-178, database is CAplus.

A drop method using fluorinated hydrocarbon (FC-72) was successfully applied as a quant. assay to determine the threshold concentration of cochliophilin A, a potent Aphanomyces cochlioides zoospore attractant originally isolated from spinach roots. This method revealed that the number of zoospores attracted to droplets containing cochliophilin A increased with time, until approx. 60 to 90 s after injection of the droplet into a zoospore suspension. The threshold concentration, above which cochliophilin A was able to function as a zoospore attractant, was determined to be ∼3.0×10^-9 M. Interestingly, zoospores attracted to droplets containing cochliophilin A at a concentration greater than 1.1×10^-7 M massed on the surface of the droplets, a behavior that was quite similar to that observed on the root surface of host plants. This result suggested that the drop method would be useful not only as a quant. assay of chemotaxis, but also as a technique to investigate the mechanism of zoospore massing.

Nippon Shokubutsu Byori Gakkaiho published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C5H7FO2, Product Details of C16H10O5.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Vershinin, S. S. published the artcileStereochemical aspect of 2,2,4-trimethyl-1,3-dioxolane bromination by molecular bromine, Synthetic Route of 1193-11-9, the publication is Bashkirskii Khimicheskii Zhurnal (2015), 22(1), 92-95, database is CAplus.

Bromination of 2,2,4-trimethyl-1,3-dioxolane by mol. bromine in carbon tetrachloride with molar ratio of dioxolane:Br₂:CCl₄ equal to 1:1:5 at the boiling temperature of the reaction mixture occurs regio- and stereoselectively with full conversion of the substrate to 61% of cis-2-bromomethyl-2,4-dimethyl-1,3-dioxolane and 39% of trans-2-bromomethyl-2,4-dimethyl-1,3-dioxolane. The structure, configuration, and the molar ratio of the isomers were determined by ¹H and ¹³C NMR and gas chromatog. The predominant conformation of the obtained bromodioxolanes is half-chair with pseudoequatorial position of the CH₃-group at carbon atom C-4 with prevalence of the cis-isomer with equatorial orientation of the bromoalkyl substitute.

Bashkirskii Khimicheskii Zhurnal published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C9H12O, Synthetic Route of 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem