Dioxole related

Chandrasekhar, Sosale published the artcileChloral Hydrate as a Water Carrier for the Efficient Deprotection of Acetals, Dithioacetals, and Tetrahydropyranyl Ethers in Organic Solvents, SDS of cas: 177-10-6, the publication is Synthetic Communications (2014), 44(13), 1904-1913, database is CAplus.

The efficient deprotection of several acetals, dithioacetals, and tetrahydropyranyl (THP) ethers under ambient conditions, using chloral hydrate in hexane, is described. Excellent yields were realized for a wide range of both aliphatic and aromatic substrates. The method is characterized by mild conditions (room temperatures or below), simple workup, and the ready availability of chloral hydrate. High chemoselectivity was also observed in the deprotection, acetonides, esters, and amides being unaffected under the reaction conditions. Products were generally purified chromatog. and identified spectrally. These results constitute a novel addition to current methodol. involving a widely employed deprotection tactic in organic synthesis. It seems likely that the mechanism of the reaction involves adsorption of the substrate on the surface of the sparingly soluble chloral hydrate.

Synthetic Communications published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, SDS of cas: 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Yu, Xiao-Qiang published the artcileRhodium-catalyzed 1,4-addition of lithium 2-furyltriolborates to unsaturated ketones and esters for enantioselective synthesis of γ-oxo-carboxylic acids by oxidation of the furyl ring with ozone, Synthetic Route of 503538-69-0, the publication is Chemistry – An Asian Journal (2011), 6(3), 932-937, database is CAplus and MEDLINE.

Rhodium-catalyzed 1,4-addition of lithium 5-methyl-2-furyltriolborate ([ArB(OCH₂)₃CCH₃]Li, Ar=5-methyl-2-furyl) to unsaturated ketones to give β-furyl ketones was followed by ozonolysis of the furyl ring for enantioselective synthesis of γ-oxo-carboxylic acids. [Rh(nbd)₂]BF₄ (nbd=2,5-norbornadiene) chelated with 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (binap) or 2,3-bis(diphenylphosphino)butane (chiraphos) gave high yields and high selectivities in a range of 91-99 % ee at 30 °C in a basic dioxane/water solution The corresponding reaction of unsaturated esters, such as Me crotonate, had strong resistance under analogous conditions, but the 1,4-adduct was obtained in 70 % yield and with 94 % ee when more electron-deficient Ph crotonate was used as the substrate.

Chemistry – An Asian Journal published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C10H11N3O3S, Synthetic Route of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Ishida, Naoki published the artcile1,5-Rhodium Shift in Rearrangement of N-Arenesulfonylazetidin-3-ols into Benzosultams, Formula: C38H24F4O4P2, the publication is Journal of the American Chemical Society (2013), 135(51), 19103-19106, database is CAplus and MEDLINE.

In the presence of [Rh(COD)(OH)]₂ and the nonracemic bibenzodioxolediphosphine (R)-difluorphos, 1-arylsulfonyl-3-aryl-3-azetidinols such as I (R = Ph, 4-MeOC₆H₄, 4-F₃CC₆H₄; Ts = 4-MeC₆H₄SO₂) underwent enantioselective rearrangement to give fused thiazinediones such as II (R = Ph, 4-MeOC₆H₄, 4-F₃CC₆H₄) in 90-95% yields and in 91:9-93:7 er. Stereoselective rearrangement of nonracemic amino acid-derived 1-arylsulfonyl-3-aryl-3-azetidinols such as III (R¹ = Ph, 4-MeOC₆H₄, 4-F₃CC₆H₄; R² = Me, Me₂CH, MeSCH₂CH₂; R³ = H, Me, MeO, F₃C; R⁴ = H, Me) in the presence of racemic 2,2′-bis{bis(3,5-xylyl)phosphino}-1,1′-binaphthyl yielded fused dihydrohydroxythiazinediones such as IV (R¹ = Ph, 4-MeOC₆H₄, 4-F₃CC₆H₄; R² = Me, Me₂CH, MeSCH₂CH₂; R³ = H, Me, MeO, F₃C; R⁴ = H, Me) as single diastereomers and enantiomers in 97-99% yields. Rearrangement of I (R = Ph) with a perdeuterated tosyl group yielded a deuterated product monolabeled at the N-Me group; a mechanism for the rearrangement is proposed. The structure of IV (R¹ = Ph; R² = Me; R³ = Me; R⁴ = H) was determined by X-ray crystallog.

Journal of the American Chemical Society published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Formula: C38H24F4O4P2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Sakihama, Yasuko published the artcileA photoaffinity probe designed for host-specific signal flavonoid receptors in phytopathogenic Peronosporomycete zoospores of Aphanomyces cochlioides, Related Products of dioxole, the publication is Archives of Biochemistry and Biophysics (2004), 432(2), 145-151, database is CAplus and MEDLINE.

Aphanomyces cochlioides zoospores show chemotaxis to cochliophilin A (5-hydroxy-6,7-methylenedioxyflavone, 1), a host derived attractant, and also respond to 5,7-dihydroxyflavone (2) known as an equivalent chemoattractant. To investigate the chemotactic receptors in the zoospores, we designed photoaffinity probes 4′-azido-5,7-dihydroxyflavone (3) and 4′-azido-7-O-biotinyl-5-hydroxyflavone (4) considering chem. structure of 2. Both 3 and 4 had zoospore attractant activity which was competitive with that of 1. When zoospores were treated with the biotinylated photoaffinity probe followed by UV irradiation and streptavidin-gold or peroxidase-conjugated streptavidin, probe-labeled proteins were detected on the cell membrane. This result indicated that the 1-specific-binding proteins, a candidate for hypothetical cochliophilin A receptor, were localized on the cell membrane of the zoospores. This is the first exptl. evidence of flavonoid-binding proteins being present in zoospores, using chem. synthesized azidoflavone as photoaffinity-labeling reagent.

Archives of Biochemistry and Biophysics published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Tanaka, Maya published the artcileGold-Catalyzed Enantioselective Synthesis, Crystal Structure, and Photophysical/Chiroptical Properties of Aza[10]helicenes, Product Details of C38H24F4O4P2, the publication is Chemistry – A European Journal (2016), 22(28), 9537-9541, database is CAplus and MEDLINE.

The enantioselective synthesis of an aza[10]helicene, possessing two pyridone units, has been achieved by the gold-catalyzed intramol. quadruple hydroarylation of a tetrayne. This aza[10]helicene was successfully converted into a fully aromatic aza[10]helicene, possessing two pyridine units. Structure-photophys. and chiroptical properties relationship in a series of azahelicene isomers has also been disclosed.

Chemistry – A European Journal published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C14H31NO2, Product Details of C38H24F4O4P2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Satoh, Masakazu published the artcileEnantioselective synthesis of fully benzenoid single and double carbohelicenes via gold-catalyzed intramolecular hydroarylation, Computed Properties of 503538-69-0, the publication is Chemistry – A European Journal (2018), 24(21), 5434-5438, database is CAplus and MEDLINE.

The enantioselective synthesis of fully benzenoid single and double carbo[6]helicenes was achieved via the gold-catalyzed intramol. hydroarylation. The single crystal of the racemic double carbo[6]helicene consists of unique layer structures like timbers with halving joints in the woodworking. Furthermore, the double carbo[6]helicenes exhibited relatively large circularly polarized luminescence (CPL) activities among chiral small organic mols.

Chemistry – A European Journal published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Computed Properties of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Ji, Yue published the artcileConcise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process, Category: dioxole, the publication is Journal of the American Chemical Society (2015), 137(33), 10496-10499, database is CAplus and MEDLINE.

A concise deracemization of racemic secondary and tertiary amines with a tetrahydroisoquinoline core has been successfully realized by orchestrating a redox process consisted of N-bromosuccinimide oxidation and iridium-catalyzed asym. hydrogenation. This compatible redox combination enables one-pot, single-operation deracemization to generate chiral 1-substituted 1,2,3,4-tetrahydroisoquinolines with up to 98% ee in 93% yield, offering a simple and scalable synthetic technique for chiral amines directly from racemic starting materials.

Journal of the American Chemical Society published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Category: dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Yao, Zhiwei published the artcileSynthesis and application of novel sulfonic acid-functionalized ionic liquid with benzothiazole cation, Name: 1,4-Dioxaspiro[4.5]decane, the publication is Gongye Cuihua (2013), 21(5), 54-57, database is CAplus.

A novel sulfonic acid-functionalized ionic liquid [(CH₂)₃SO₃HBth][HSO₄] was prepared with benzothiazole as the cation and hydrogen sulfate as the anion, and was used for catalyzing the ketalization of cyclohexanone with glycol. The effects of reaction time, mole ratio of reactants, the dosage of the water carrying agent and the catalyst and the repeated use of the catalyst were investigated. The results showed that 1,4-dioxaspiro[4,5]decane yield of over 97.30% was attained under the optimal reaction condition as follows: cyclohexanone amount 0.01 mol, glycol amount 0.02 mol, catalyst dosage 5% of cyclohexane mol, the amount of water carrying agent cyclohexane 10 mL, and reaction time 3 h. The catalyst possessed good stability, and its activity did not decrease obviously after repeated use for five times.

Gongye Cuihua published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C19H14O2, Name: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Khorshidi, Alireza published the artcileMagnetite nanoparticles catalyzed preparation of isatin ketals under solvent-free conditions promoted by ultrasound irradiation, Application In Synthesis of 177-10-6, the publication is Arabian Journal of Chemistry (2019), 12(8), 2470-2475, database is CAplus.

Fe₃O₄ magnetic nanoparticles (MNPs) were synthesized via chem. precipitation method and used as an efficient and recyclable catalyst in ketalization of isatins I (X = H, 5-Cl, 5-Br, 7-Cl). It was found that a solvent-free process, under irradiation of sonic waves provides good to excellent yields of the desired ketals II (n = 2, 3).

Arabian Journal of Chemistry published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Application In Synthesis of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Du, Yijun published the artcilePreparation of a novel solid acid catalyst with Lewis and Bronsted acid sites and its application in acetalization, Safety of 1,4-Dioxaspiro[4.5]decane, the publication is Turkish Journal of Chemistry (2014), 38(1), 157-163, database is CAplus.

A novel melamine-formaldehyde resin (MFR) supported solid acid with Lewis and Bronsted acid sites was synthesized through the immobilization of acidic ionic liquid and cuprous ion on MFR. The SEM (SEM) characterization showed that addition of PEG-2000 in the synthesis of MFR could promote the formation of regular particles with diameters around 3.7 μm. The XRD pattern demonstrated that some cuprous ions were aggregated. The catalytic performance of this acid catalyst was evaluated by acetalization. The results showed that the catalytic activity of MFR with Bronsted acid could be improved by addition of Lewis acid. The solid acid was very efficient for the acetalization of carbonyl compounds and diols with moderate to excellent yields and there was no loss of catalytic activity even after being recycled for 6 runs.

Turkish Journal of Chemistry published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Safety of 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem