Dioxole related

Meslard, J. C. published the artcileSynthesis of cyclic acetals under mild conditions. Applications to the acetalization of chloramphenicol, Quality Control of 1193-11-9, the publication is Bulletin de la Societe Chimique de France (1985), 84-9, database is CAplus.

Acetalization of 1-2 and 1-3 diols, even as sterically crowded as chloramphenicol, by carbonyl derivatives with substituents of various sizes has been performed at room temperature under mild conditions, by using heterogeneous catalysis (sulfonated polystyrene) in the presence of mol. sieves. Several new acetals of chloramphenicol e.g. I, have thus been obtained in good yields, isolated and characterized.

Bulletin de la Societe Chimique de France published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Quality Control of 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Mao, Deshou published the artcileAnalysis of volatile constituents from cocoa extract (Theobroma cacao. L) by using stir bar sorptive extraction-thermal desorption/gas chromatography-mass spectrometry, Product Details of C11H14O4, the publication is Xiangliao Xiangjing Huazhuangpin (2012), 5-9, 13, database is CAplus.

The volatile constituents of Cocoa extract were identified by using stir bar sorptive extraction-thermal desorption/gas chromatog.-mass spectrometry (SBSE-TDU/GC-MS). With the MS library search and retention index comparison, 73 compounds were confirmed with PDMS twister, and the main constituents included isovaleric acid (25.28%), isovaleraldehyde propylene glycol acetal (14.57%), benzyl acetate (10.60%), 1,2-propylene glycol (9.17%), phenethyl alc. (9.00%), dibenzyl ketone (5.00%), phenethyl phenylacetate (4.50%), isoamyl isovalerate (3.63%), 2,3,5-trimethylpyrazine (2.34%), 2-methoxy-3-Me pyrazine (2.29%), 2-isopropyl-5-methyl-2-hexenal (1.53%), Et linoleate (1.25%) and acetic acid (1.10%), while with EG-silicone twister, 59 chems. were determined, which included the following main compounds: 2,3,5-trimethylpyrazin (63.59%), acetic acid (12.06%), isovaleraldehyde propylene glycol acetal (4.96%), benzyl acetate (3.92%), palmitic acid (1.89%), guaiacol (1.41%), isovaleric acid (1.08%), dibenzyl ketone (1.08%) and glycerin (1.01%). The research provided technol. supports for exploitation and quality control of cocoa extract

Xiangliao Xiangjing Huazhuangpin published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, Product Details of C11H14O4.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Umeda, Rui published the artcileDesymmetrization of 1,4-Cyclohexadienyltriisopropoxysilane Using Copper Catalysis, Application In Synthesis of 503538-69-0, the publication is Organic Letters (2007), 9(11), 2175-2178, database is CAplus and MEDLINE.

The first catalytic desymmetrization in the field of allylsilane chem. is presented. Desymmetrization of cyclohexadienyltriisopropoxysilane is achieved using copper catalysis. High diastereo- and enantioselectivities are obtained, and the product dienes are highly valuable building blocks for natural product synthesis.

Organic Letters published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C7H5Cl2NO, Application In Synthesis of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Mykhailiuk, Pavel K. published the artcile1-Amino-4,4-difluorocyclohexanecarboxylic acid as a promising building block for drug discovery: design, synthesis and characterization, HPLC of Formula: 177-10-6, the publication is Tetrahedron (2013), 69(20), 4066-4075, database is CAplus.

1-Amino-4,4-difluorocyclohexanecarboxylic acid has been designed as a fluorinated analog of the pharmacol. relevant 1-aminocyclohexanecarboxylic acid. The synthesis has been performed in three steps from a com. available material in 22% overall yield. An impact of fluorine atoms on conformation, lipophilicity, acidity and fluorescent properties of the amino acid has been studied. Various practical applications of the obtained compound are suggested.

Tetrahedron published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, HPLC of Formula: 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Liao, Xuebin published the artcileEnantioselective Total Syntheses of (-)-Taiwaniaquinone H and (-)-Taiwaniaquinol B by Iridium-Catalyzed Borylation and Palladium-Catalyzed Asymmetric α-Arylation, Category: dioxole, the publication is Journal of the American Chemical Society (2011), 133(7), 2088-2091, database is CAplus and MEDLINE.

We report a concise, enantioselective total synthesis of (-)-taiwaniaquinone H (I) and the first enantioselective total synthesis of (-)-taiwaniaquinol B (II) by a route that includes asym. palladium-catalyzed α-arylation of a ketone with an aryl bromide that was generated by sterically controlled halogenation via iridium-catalyzed C-H borylation. This asym. α-arylation creates the benzylic quaternary stereogenic center present in the taiwaniaquinoids. The synthesis was completed efficiently by developing a Lewis acid-promoted cascade to construct the [6,5,6] tricyclic core of an intermediate common to the synthesis of a number of taiwaniaquinoids. Through the preparation of these compounds, we demonstrate the utility of constructing benzylic quaternary stereogenic centers, even those lacking a carbonyl group in the α-position, by asym. α-arylation.

Journal of the American Chemical Society published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Category: dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Gerten, Anthony L. published the artcileEnantioselective dearomative [3 + 2] cycloadditions of indoles with azomethine ylides derived from alanine imino esters, Related Products of dioxole, the publication is Organic Chemistry Frontiers (2016), 3(3), 339-343, database is CAplus.

Catalytic, enantioselective [3 + 2] cycloadditions of azomethine ylides derived from alanine imino esters with 3-nitroindoles were reported. The dearomative cycloaddition reactions occurred in the presence of a catalyst generated in situ from Cu(OTf)₂ and (R)-Difluorphos to form exo’-pyrroloindoline cycloadducts and established four contiguous stereogenic centers, two of which were fully substituted. The exo’-pyrroloindoline products were formed in moderate-to-good yields (39-85%) with high diastereoselectivities (up to 98 : 1 : 1 dr) and enantioselectivities (up to 96% ee).

Organic Chemistry Frontiers published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Berthet, Matheo published the artcileCatalytic Alkynylation of Cyclic Acetals and Ketals Enabled by Synergistic Gold(I)/Trimethylsilyl Catalysis, Quality Control of 177-10-6, the publication is Journal of Organic Chemistry (2017), 82(18), 9916-9922, database is CAplus and MEDLINE.

A completely regioselective and challenging gold(I)-catalyzed ring-opening of cyclic 1,3-dioxolanes and dioxanes by trimethylsilyl alkynes to set diol-derived propargyl trimethylsilyl bis-ethers is reported. This unprecedented and not trivial transformation does not operate with the catalytic methodologies recently reported for catalytic alkynylation of acyclic acetals/ketals, and is uniquely enabled by the application of a recently introduced synergistic gold(I)-silicon catalysis concept capable of producing simultaneously catalytic amounts of two key players, a silicon-based Lewis superacid and a nucleophilic gold acetylide.

Journal of Organic Chemistry published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Quality Control of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Li, Ruiyun published the artcileEfficient and reusable SBA-15-immobilized Bronsted acidic ionic liquid for the ketalization of cyclohexanone with glycol, Synthetic Route of 177-10-6, the publication is RSC Advances (2018), 8(13), 7179-7185, database is CAplus and MEDLINE.

Ketalization of cyclohexanone with glycol has been carried out using mol. sieve SBA-15 immobilized Bronsted acidic ionic liquid catalyst. The properties of the heterogeneous catalysts were characterized by elemental anal., Fourier transform IR spectra, SEM, thermogravimetry/differential scanning calorimetry, and N₂ adsorption-desorption. The results suggested that Bronsted acidic ionic liquid [BSmim][HSO₄] had been successfully immobilized on the surface of SBA-15 and the catalytic performance evaluation demonstrated that the catalyst BAIL@SBA-15 exhibited excellent catalytic activities in the ketalization of cyclohexanone with glycol. In addition, the effects of reaction temperature, catalyst loading, reaction time, and reactant molar ratio have also been investigated in detail, and a general reaction mechanism for the ketalization of cyclohexanone with glycol was given. The SBA-15 immobilized ionic liquid can be recovered easily and after reusing for 5 times in the ketalization reaction, the catalyst could still give satisfactory catalytic activity.

RSC Advances published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Synthetic Route of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Partridge, Benjamin M. published the artcileIridium-catalyzed arylative cyclization of alkynones by 1,4-iridium migration, Safety of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, the publication is Angewandte Chemie, International Edition (2014), 53(25), 6523-6527, database is CAplus and MEDLINE.

1,4-Metal migrations enable the remote functionalization of C-H bonds, and were utilized in a wide variety of valuable synthetic methods. The vast majority of existing examples involve the 1,4-migration of Pd or Rh. Herein, the stereoselective synthesis of complex polycycles by the Ir-catalyzed arylative cyclization of alkynones with arylboronic acids is described.

Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Safety of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Bennet, Andrew J. published the artcileOxygen-18 and secondary deuterium kinetic isotope effects confirm the existence of two pathways for acid-catalyzed hydrolyses of α-arabinofuranosides, Safety of 2,2,4-Trimethyl-1,3-dioxolane, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1985), 1233-6, database is CAplus.

The ¹⁸O kinetic isotope effects observed in the HClO₄-catalyzed hydrolysis of 4-nitrophenyl and iso-Pr α-arabinofuranoside-1–¹⁸O and the secondary D effect observed in the hydrolysis of propan-2-yl-2–d α-arabinofuranoside suggest that the nitrophenyl glycoside reacts with exocyclic C-O cleavage and the propan-2-yl glycoside by endocyclic C-O cleavage.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Safety of 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem