The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide( cas:707-61-9 ) is researched.Synthetic Route of C11H13OP.Schirmer, Marie-Luis; Jopp, Stefan; Holz, Jens; Spannenberg, Anke; Werner, Thomas published the article 《Organocatalyzed Reduction of Tertiary Phosphine Oxides》 about this compound( cas:707-61-9 ) in Advanced Synthesis & Catalysis. Keywords: organocatalyzed reduction tertiary phosphine oxide; phosphine borane preparation crystal mol structure. Let’s learn more about this compound (cas:707-61-9).
A novel selective catalytic reduction method of tertiary phosphine oxides to the corresponding phosphines has been developed. Notably, the reaction proceeds smoothly with low catalyst loadings of 1-5 mol% even at low temperature (70°). Under the optimized conditions various phosphine oxides could be selectively reduced and the desired phosphines were usually obtained in excellent yields above 90%. Furthermore, authors have developed a one-pot reaction sequence for the preparation of valuable phosphine·borane adducts. Simple addition of BH3·THF subsequent to the reduction step gave the desired adducts in yields up to 99%.
In addition to the literature in the link below, there is a lot of literature about this compound(4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide)Synthetic Route of C11H13OP, illustrating the importance and wide applicability of this compound(707-61-9).
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem