Facile Conversion of Cyclopropanols into Linear Conjugate Enones was written by Han, Wei-Bo;Li, Shao-Gang;Lu, Xiao-Wei;Wu, Yikang. And the article was included in European Journal of Organic Chemistry in 2014.Application of 6413-10-1 The following contents are mentioned in the article:
A practical method for the conversion of 1,2-disubstituted cyclopropanol derivatives obtained by a a Kulinkovich cyclopropanation into linear enones was developed. The approach features regioselective cleavage of the cyclopropane rings in EtOH at ambient temperature with inexpensive and readily available bis(acetylacetonate)cobalt [Co(acac)2] as a catalyst and air as a reagent. The crude intermediate peroxides were directly reduced with Ph3P to afford the corresponding β-hydroxy ketones, which, on mesylation and β-elimination performed in a one-pot manner, furnished the end products in good to excellent yields after only one chromatog. step at the end of the whole sequence. The synthesis of the target compounds was achieved using (1R,2R)-rel-2-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-1-(methyl)cyclopropanol and related compounds as key reactants. The title compounds thus formed included (3E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hexen-2-one (alkenone derivative). This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Application of 6413-10-1).
Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application of 6413-10-1
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem