Polysubstituted Oxygen Heterocycles by a Reformatsky-Type Reaction/Reductive Cyclization Approach from Enantiopure β-Ketosulfoxides was written by Colobert, Francoise;Choppin, Sabine;Ferreiro-Mederos, Leticia;Obringer, Michel;Luengo Arratta, Sandra;Urbano, Antonio;Carreno, M. Carmen. And the article was included in Organic Letters in 2007.HPLC of Formula: 6413-10-1 The following contents are mentioned in the article:
The stereoselective synthesis of tetrasubstituted tetrahydrofurans and trisubstituted tetrahydropyrans bearing a sulfoxide moiety was achieved by reductive cyclization (Et3SiH/TMSOTf) of the corresponding enantiopure hydroxy ketones protected as dioxolanes. The latter are easily accessible from a Reformatsky-type reaction between α-bromo-α’-sulfinyl ketones and protected α- or β-ketoaldehydes, followed by diastereoselective reduction of the resulting β-ketosulfoxide. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1HPLC of Formula: 6413-10-1).
Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.HPLC of Formula: 6413-10-1
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem