Category: Dioxole

Tahara, S. published the artcileSimple flavones possessing complex biological activity, Name: 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, the publication is Studies in Natural Products Chemistry (2000), 457-505, database is CAplus.

A review with 87 references Two simple flavones, each of which exhibits distinct biol. activity despite their closely related structures, have been recognized by detailed bioassays, and bioassay-oriented isolation procedures. The identity of both flavones has been confirmed by synthesis. One of these compounds, 5-methoxy-6,7-methylenedioxyflavone has been found in an extract of Polygonum lapathifolium L. subsp. nodosum (Polygonaceae) using a screening test devised to detect antidotes against the benzimidazole fungicide, benomyl (or its active principle MBC, 1H-benzimidazol-2-ylcarbamic acid Me ester). The other compound, 5-hydroxy-6,7-methylenedioxyflavone, is a host-specific signalling substance that exudes from spinach roots and attracts zoospores of the phytopathogenic fungus Aphanomyces cochlioides the cause of spinach root rot. This review describes the bioassay, isolation and identification of these active compounds, and compares their activity with that of various other related, and unrelated, chems. of either plant or synthetic origin. The possible ecochem. role and mode of action of flavone and non-flavone antidotes and attractants is briefly discussed.

Studies in Natural Products Chemistry published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C8H8O3, Name: 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Senda, Yasuhisa published the artcileCarbon-13 NMR spectra of methyl-1,3-dioxolanes, Application In Synthesis of 1193-11-9, the publication is Bulletin of the Chemical Society of Japan (1977), 50(10), 2813-14, database is CAplus.

The ¹³C NMR spectra of 13 Me substituted 1,3-dioxolanes were measured. The carbon chem. shifts of the Me groups imply that the 1,3-transannular nonbonded interaction of the Me groups is negligible, except in the cases of 2,2,4-trimethyl- and 2,2,4,5-tetramethyl-1,3-dioxolanes.

Bulletin of the Chemical Society of Japan published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C4H6N2, Application In Synthesis of 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Wen, Yaolin published the artcilePhenolic constituents of Celosia cristata L. susceptible to spinach root rot pathogen Aphanomyces cochlioides, Related Products of dioxole, the publication is Bioscience, Biotechnology, and Biochemistry (2006), 70(10), 2567-2570, database is CAplus and MEDLINE.

Cochliophilin A (5-hydroxy-6,7-methylenedioxyflavone, 1), known as a host-specific attractant towards the zoospores of A. cochlioides, a cause of root rot and damping-off diseases of Chenopodiaceae, was found in the Amaranthaceae plant, Celosia cristata, that is susceptible to the pathogen. The content of 1 in Celosia seedlings was quantified as 1.4 μg/g fresh weight A new isoflavone, cristatein (5-hydroxy-6-hydroxymethyl-7,2′-dimethoxyisoflavone, 2), and five known flavonoids were also identified.

Bioscience, Biotechnology, and Biochemistry published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C9H7NO4, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Islam, Tofazzal Md. published the artcileMicroscopic studies on attachment and differentiation of zoospores of the phytopathogenic fungus Aphanomyces cochlioides, Safety of 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, the publication is Journal of General Plant Pathology (2002), 68(2), 111-117, database is CAplus.

The mode of aggregation, attachment and differentiation of zoospores of the phytopathogenic fungus Aphanomyces cochlioides when interacting with the host and a host-specific attractant and a G-protein activator, mastoparan, was studied by light and SEM. When a zoospore approached very close to the host root, it seemed to halt, then coiled its anterior flagellum on its body. The halted zoospore appeared to contact the host surface with its posterior flagellum, which gradually drew the encysting zoospore onto the root surface. The spore then docked precisely on the root surface at its ventral face with the help of the posterior flagellum and anchored itself by releasing some adhesive materials. The adherent spore became a spherical after shedding its flagella and rapidly turned into an expanded cyst forming a smooth cyst coat around it, and finally changed into a smaller cystospore covered with a wrinkled surface. In contrast, the mastoparan- or cochliophilin A-stimulated zoospores on artificial membranes aggregated by using their posterior flagella before encystment. These contrasting phenomena suggest that A. cochlioides zoospores may use their posterior flagella for successful docking on the host surface or for aggregation of encysting spores in the absence of the host.

Journal of General Plant Pathology published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, Safety of 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Likhterov, V. R. published the artcile1,3-Dioxolanes. I. Chlorination of some cyclic ketals of acetone and vicinal glycols, Product Details of C6H12O2, the publication is Zhurnal Organicheskoi Khimii (1968), 4(1), 69-72, database is CAplus.

Chlorination of 2,2,4-trimethyl-1,3-dioxolane (I), 2,2-dimethyl-4-chloromethyl-1,3-dioxolane, 2,2-dimethyl-4-methoxymethyl-1,3-dioxolane, 2,2-dimethyl-4-acetoxymethyl-1,3-dioxolane (II), and 2,2-dimethyl-1,3-dioxolane is described. The exothermic reaction was carried out with cooling at 15-20° by passing Cl through the dioxolane followed by distillation The starting dioxolanes were all known previously with the exception of II, b2 71-2°. Chlorination gave 2-chloromethyl-2-methyl-4-(R-substituted)-1,3-dioxolanes (III) (R, % yield, b.p./mm., and n20D given): Me, 73.5, 53-4°/15, 1.4352; CH2Cl, 78.3, 71-2°/2, 1.4701; MeOCH2, 71.3, 69-71°/2, 1.4486; MeCO2CH2, 72.0, 103-5°/2, 1.4535; H, 76.0, 60-3°/20, 1.4450. Alk. hydrolysis of III (R = MeCO2CH2) gave III (R = CH2OH), b3 96-8°, n20D 1.4688 (containing 46-50% cis- and 50-4% trans-isomer). Reaction of III (R = CH2Cl) with MeCO2K gave III (R = MeCO2CH2). Action of PCl5 on III (R = CH2OH) gave III (R = CH2Cl). Hydrolysis of III gave MeCOCH2Cl, identified by the m.p. of its 2,4-dinitrophenylhydrazone derivative

Zhurnal Organicheskoi Khimii published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Product Details of C6H12O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Lu, Ting published the artcileFour Strandberg-type polyoxometalates with organophosphine centre decorated by transition metal-2,2′-bipy/H₂O complexes, Recommanded Product: 1,4-Dioxaspiro[4.5]decane, the publication is Journal of Solid State Chemistry (2017), 52-57, database is CAplus.

Four inorganic-organic hybrid compounds composed of Strandberg-type organophosphomolybdate anion [(C₆H₅PO₃)₂Mo₅O₁₅]^4- (abbreviated as (PhP)₂Mo₅) and transition metal (TM)-2,2′-bipy/H₂O complex units, namely [(TM(H₂O)(bipy))₂(C₆H₅PO₃)₂Mo₅O₁₅]_n (TM = Co, (1); Ni, (2)), [(Cu(bipy)₂)₂(C₆H₅PO₃)₂Mo₅O₁₅]·2H₂O (3) and [(Zn(bipy)(μ-OH))₂(Zn(bipy)₂(C₆H₅PO₃)₂Mo₅O₁₅)₂]·3H₂O (4) (bipy = 2,2′-bipyridine), were successfully constructed under hydrothermal conditions, and their structures were determined by single crystal x-ray diffraction anal. and spectroscopic methods. The central heteroatoms in these polyoxometalates (POMs) are all organophosphine (RP) groups. Compound 1 and compound 2 are isostructural (PhP)₂Mo₅-based TM-coordination polymers with the two-dimensional layer frameworks. In compound 3, the bi-supporting structure containing one (PhP)₂Mo₅ unit and two [Cu(bipy)₂]²⁺ cations. For compound 4, it can be regarded as a dimer of two bi-supporting {Zn(bipy)₂(PhP)₂Mo₅Zn(bipy)} clusters that were connected by two μ-OH groups. The acid-catalytic activities and fluorescence properties of the four hybrids have been investigated.

Journal of Solid State Chemistry published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Recommanded Product: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Yuan, Zhenbo published the artcilePalladium-Catalyzed Asymmetric Intramolecular Reductive Heck Desymmetrization of Cyclopentenes: Access to Chiral Bicyclo[3.2.1]octanes, Application In Synthesis of 503538-69-0, the publication is Angewandte Chemie, International Edition (2019), 58(9), 2884-2888, database is CAplus and MEDLINE.

A palladium-catalyzed asym. reductive Heck reaction of unactivated aliphatic alkenes, with eliminable β-hydrogen atoms, was realized for the first time. A series of optically active bicyclo[3.2.1]octanes bearing chiral quaternary and tertiary carbon stereocenters were obtained in good yields with excellent enantioselectivities, exhibited good functional-group tolerance and scalability. Moreover, deuterated optically active bicyclo[3.2.1]octanes were also obtained in high efficiency.

Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C9H10O4, Application In Synthesis of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Rigo, Davide published the artcileAcid-Catalyzed Reactions of Isopropenyl Esters and Renewable Diols: A 100% Carbon Efficient Transesterification/Acetalization Tandem Sequence, from Batch to Continuous Flow, Recommanded Product: 2,2,4-Trimethyl-1,3-dioxolane, the publication is ACS Sustainable Chemistry & Engineering (2019), 7(23), 18810-18818, database is CAplus.

A new acid-catalyzed tandem sequence was investigated for the upgrading of renewable 1,2-diols such as propylene glycol (PG) and ethylene glycol (EG), with isopropenyl esters. For example, at 50 °C and in the presence of Amberlyst-15, the reaction of PG with nontoxic isopropenyl acetate allowed an initial irreversible monotransesterification of the diol, releasing acetone which then promoted acetalization on a second mol. of the glycol. The overall protocol was 100% carbon efficient, affording water as the sole byproduct. The reaction scope was extended to higher homologs of enol esters as isopropenyl-octanoate and phenylbutyrate. Addnl., the tandem sequence was successfully transferred in the continuous-flow (CF) mode where the catalyst (Amberlyst-15) could be used virtually indefinitely without loss of performance, and the solvent (THF or CPME) was quant. recovered and reused. Under CF conditions, the reaction of PG with isopropenyl acetate could be run at 30 °C and atm. pressure with a (nonoptimized) productivity up to 9.7 mmol g_cat^-1 h^-1, 3 times higher than that achieved in the batch mode. When ethylene glycol was used, a lower tandem selectivity was observed due to predominance of transesterification products, mono- and diesters, over the acetal compound A 100% carbon efficient upgrading of renewable 1,2-diols through tandem monotransesterification and acetalization reactions mediated by isopropenyl esters is presented.

ACS Sustainable Chemistry & Engineering published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Recommanded Product: 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Shan, Gang published the artcileC-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors, Recommanded Product: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, the publication is Angewandte Chemie, International Edition (2018), 57(43), 14250-14254, database is CAplus and MEDLINE.

In the presence of a nonracemic cyclopentenopyridine rhodium complex, O-(arylpentynyl) arylhydroxamates such as I underwent enantioselective C-H activation and cyclization reactions mediated by dibenzoyl peroxide and CsOAc in 2-chloroethanol/1,2-dichloroethane to yield atropisomeric arylisoquinolinones such as II in 45-95% yields and in 78:22-96:4 er. Five of the arylisoquinolinone products (including II) inhibited the Hedgehog pathway in human cells; one of the compounds tested inhibited the Hedgehog pathway but did not displace labeled cyclopamine from Smoothened, implying that at least one of the arylisoquinolinones does not inhibit the Hedgehog pathway through binding to Smoothened.

Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C18H34N4O5S, Recommanded Product: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Liu, Taotao published the artcileZeolite nanofiber assemblies as acid catalysts with high activity for the acetalization of carbonyl compounds with alcohols, Category: dioxole, the publication is RSC Advances (2014), 4(35), 18217-18221, database is CAplus.

Zeolite nanofiber assemblies (HNB-MOR) as efficient heterogeneous catalysts for the formation of a range of acetals in good yields. The mesoporosity of HNB-MOR benefits mass transfer, and the strong acidic sites on HNB-MOR facilitate acetalization activity. The catalyst can be reused 10 times without loss of activity.

RSC Advances published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Category: dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem