Category: Dioxole

Godefroi, Erik F. et al. published their research in Journal of Medicinal Chemistry in 1969 | CAS: 3418-21-1

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Preparation and antimycotic properties of derivatives of 1-phenethylimidazole was written by Godefroi, Erik F.;Heeres, Jan;Van Cutsem, Jan;Janssen, Paul A. J.. And the article was included in Journal of Medicinal Chemistry in 1969.Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

The synthesis of a large number of β-substituted-1-phenethylimidazoles is described. Many appropriately N-substituted-1-(β-aminophenethyl)imidazoles and cyclic ketals derived from 2-(1-imidazolyl)acetophenones were quite active against dermatophytes. However, 1-(β-benzyloxyphenethyl)-imidazoles displayed potent, broad-spectrum activity, not only against dermatophytes but also against yeast cells (Candida albicans) and gram-pos. bacteria. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Macaev, Fliur et al. published their research in Bioorganic & Medicinal Chemistry in 2005 | CAS: 3418-21-1

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 3418-21-1

Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure-antimycobacterial activities was written by Macaev, Fliur;Rusu, Ghenadie;Pogrebnoi, Serghei;Gudima, Alexandru;Stingaci, Eugenia;Vlad, Ludmila;Shvets, Nathaly;Kandemirli, Fatma;Dimoglo, Anatholy;Reynolds, Robert. And the article was included in Bioorganic & Medicinal Chemistry in 2005.SDS of cas: 3418-21-1 This article mentions the following:

The preparation of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the computer-aided study of their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv (ATCC 27294) are reported. The average accuracy of the electronic-topol. method and neural network methods applied to the activity prediction in leave-one-out cross validation is 80%. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1SDS of cas: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Fournier, M. et al. published their research in Bulletin des Societes Chimiques Belges in 1984 | CAS: 3418-21-1

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 3418-21-1

A new method for bromination: use of tetrabutylammonium tribromide was written by Fournier, M.;Fournier, F.;Berthelot, J.. And the article was included in Bulletin des Societes Chimiques Belges in 1984.Application of 3418-21-1 This article mentions the following:

Styrenes and ketones were treated with Bu4N+ Br3– to give the resp. dibromo derivatives and α-bromo ketones. Thus, PhCH:CH2 was treated with Bu4N+ Br3– to give PhCHBrCH2Br2. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Application of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Olszewski, Tomasz K. et al. published their research in Journal of Organometallic Chemistry in 2010 | CAS: 118336-86-0

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 118336-86-0

Lithiated anions derived from (alkenyl)pentamethyl phosphoric triamides: Useful synthons for the stereoselective synthesis of 9-oxo- and 10-hydroxy-2(E)-decenoic acids, important components of queen substance and royal jelly of honeybee Apis mellifera was written by Olszewski, Tomasz K.;Bomont, Catherine;Coutrot, Philippe;Grison, Claude. And the article was included in Journal of Organometallic Chemistry in 2010.Reference of 118336-86-0 This article mentions the following:

Lithiated anions derived from (alkenyl)pentamethyl phosphoric triamides as homoenolate equivalent are used in the reaction with halogenated acetal and ketal giving regioselectively the γ-alkylation adducts. Chemoselective acidic hydrolysis of the enephosphoramide moiety in the presence of acetal or ketal groups leads to expected carbonyl products, key intermediates in the synthesis of natural compounds The synthetic potential of the presented strategy is illustrated by stereoselective synthesis of two pheromones namely, 9-oxo-2(E)-decenoic acid from queen substance and 10-hydroxy-2(E)-decenoic acid from royal jelly of honeybee Apis mellifera. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Reference of 118336-86-0).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 118336-86-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Giedyk, Maciej et al. published their research in Nature Catalysis in 2020 | CAS: 118336-86-0

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C7H13ClO2

Photocatalytic activation of alkyl chlorides by assembly-promoted single electron transfer in microheterogeneous solutions was written by Giedyk, Maciej;Narobe, Rok;Weiss, Sophia;Touraud, Didier;Kunz, Werner;Koenig, Burkhard. And the article was included in Nature Catalysis in 2020.Formula: C7H13ClO2 This article mentions the following:

Photoredox catalysis has developed into a powerful tool for the synthesis of organic compounds with diverse structures. However, stable carbon-chloride bonds remain beyond the energetic limits of the outer-sphere photoreductive activation. Herein, the organization of the reacting species in microstructured, aqueous solutions is demonstrated which allows generation of carbon-centered radicals from non-activated alkyl chlorides in the presence of double bonds via assembly-promoted single electron transfer. Photocatalytic systems consisting of a surfactant, organic substrates and additives have been designed, characterized and applied for radical dechlorination, addition and cyclization reactions. Cheap and com. available blue light-emitting diodes are used as the irradiation source for the transformations. Mechanistic studies indicate the accumulation of the energy of two visible light photons in one catalytic cycle. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Formula: C7H13ClO2).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C7H13ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Engman, Lars et al. published their research in Organometallics in 1986 | CAS: 3418-21-1

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Synthesis of diphenacyl telluride and related substances was written by Engman, Lars. And the article was included in Organometallics in 1986.Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

(PhCOCH2)2Te was prepared for the first time by a mild Na2S2O5 reduction of (PhCOCH2)2TeCl2 in a two-phase system. (RCOCH2)2TeCl2 (R = substituted Ph, 1-, 2-naphthyl, 2-thienyl, 9-anthryl, 2-benzo[b]furanyl), prepared from TeCl4 and various acetylarom. compounds, were similarly reduced to (RCOCH2)2Te. 4-Methoxyphenyl phenacyl telluride and 2-naphthyl phenacyl telluride were similarly prepared The new materials, although unstable, could be handled and characterized without special precautions. Treatment of (PhCOCH2)2Te with m-ClC6H4C(O)OOH or Na2S caused decomposition with formation of PhCOMe. Photolysis in dry benzene under N also resulted in formation of PhCOMe. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Yu, Mo-han’s team published research in Wuji Huaxue Xuebao in 30 | CAS: 177-10-6

Wuji Huaxue Xuebao published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C18H28N2O7, Computed Properties of 177-10-6.

Yu, Mo-han published the artcileSynthesis, crystal structure and catalytic property of a preyssler-type polyoxometalate modified by Mn(II) complexes, Computed Properties of 177-10-6, the publication is Wuji Huaxue Xuebao (2014), 30(6), 1221-1228, database is CAplus.

A new Preyssler-type polyoxometalate modified by Mn(II)-H2biim/H2O fragments, namely {[Mn(H2biim)2(H2O)2]2[Mn(H2biim)3]5Cl}[H(NaP5W30O110)]·20H2O (1) (H2biim = 2,2′-biimidazole) has been hydrothermally synthesized, and characterized by single-crystal x-ray diffraction, elemental anal., TGA and electrochem. anal. Its catalytic activity for synthesis of cyclohexanone ethylene ketal has been investigated. Compound 1 contains a [NaP5W30O110]14- polyoxo anion, and seven isolated Mn(II)-H2biim/H2O complex units. A 3D framework is constructed through N-HO/OW and N-HCl hydrogen bonds between H2biim mols. and polyoxo-anion or water mols., and Cl–, and π-π interactions between the imidazole rings of biimidazole ligands. Compound 1 is a new environmentally friendly catalyst and has good recyclability for the protection of carbonyl compound

Wuji Huaxue Xuebao published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C18H28N2O7, Computed Properties of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Liu, Ren-Rong’s team published research in Chemical Communications (Cambridge, United Kingdom) in 53 | CAS: 503538-69-0

Chemical Communications (Cambridge, United Kingdom) published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, SDS of cas: 503538-69-0.

Liu, Ren-Rong published the artcileEnantioselective alkynylation of N-sulfonyl α-ketiminoesters via a Friedel-Crafts alkylation strategy, SDS of cas: 503538-69-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(43), 5890-5893, database is CAplus and MEDLINE.

Enantioselective alkynylation of cyclic N-sulfonyl α-ketiminoesters I (R = H, 5-OMe, 7-Cl, etc.; R1 = Et, Me, i-Pr, n-Bu) with terminal alkynes R2CCH (R2 = C6H5, 3-FC6H4, 4-thien-2-yl, etc.) was developed by using an Ni(ClO4)2/(R)-DTBM-Segphos complex as a catalyst. A range of propargylic amides bearing quaternary stereocenters II was afforded in excellent enantioselectivities (up to 97% ee). Theor. studies revealed that this reaction proceeded via a Friedel-Crafts-type reaction pathway.

Chemical Communications (Cambridge, United Kingdom) published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, SDS of cas: 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Wang, Wei’s team published research in Journal of Materials Chemistry in 22 | CAS: 177-10-6

Journal of Materials Chemistry published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C3H5F3O, Recommanded Product: 1,4-Dioxaspiro[4.5]decane.

Wang, Wei published the artcileSelf-assembly synthesis of a high-content sulfonic acid group functionalized ordered mesoporous polymer-based solid as a stable and highly active acid catalyst, Recommanded Product: 1,4-Dioxaspiro[4.5]decane, the publication is Journal of Materials Chemistry (2012), 22(31), 15874-15886, database is CAplus.

A stable and highly active ordered mesoporous polymer-based acid catalyst has been prepared via a ethylene oxide-propylene oxide triblock copolymer surfactant templating of a formaldehyde-3-mercaptopropyltrimethoxysilane-phenol-tetraethoxysilane copolymer and oxidation of the HS to SO3H. The composition and nanostructure are characterized by XRD, NMR, XPS, TEM, nitrogen sorption, elemental and chem. anal. The sulfonic acid groups have been anchored within the well-arranged channels of the polymer-based matrix. Even with a high SO3H group loading (up to about 27.4 wt%) on the mesoporous polymer-based material, the ordered mesostructure and high surface area (∼400 m2 g-1) can be retained and the functional moieties are highly chem. accessible. With the large number of acid sites (0.93-2.38 H+ mmol g-1 determined by acid-base titration) and the hydrophobic character, the mesoporous polymer-based solid exhibits catalytic performance in acid-catalyzed reactions such as condensation and acetalization, not only high activity (per site yield of bisphenol A is over 45 in the condensation of phenol and acetone) but also excellent stability. Loss in acidic loading and activity is negligible even after the catalyst is reused 20 times in the acetalization of butanediol and aldehyde. The stability is most likely attributed to the hydrophobic nature of the mesoporous polymer-based solids, which favors the diffusion of water and thereby inhibits the poisoning of acidic sites caused by water generating in the reaction. Moreover, with large mesopores, the diffusion of reactants and products can be promoted and hence the catalytic activity can be further increased.

Journal of Materials Chemistry published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C3H5F3O, Recommanded Product: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Chen, Jingchao’s team published research in Organic Letters in 20 | CAS: 503538-69-0

Organic Letters published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Formula: C38H24F4O4P2.

Chen, Jingchao published the artcileRhodium-Catalyzed Asymmetric Arylative Ring-Opening Reactions of Heterobicyclic Alkenes with Anilines, Formula: C38H24F4O4P2, the publication is Organic Letters (2018), 20(5), 1283-1286, database is CAplus and MEDLINE.

Asym. arylative ring-opening reactions of heterobicyclic alkenes with anilines have been reported for the first time. A wide range of heterobicyclic alkenes, including azabenzonorbornadienes and oxabenzonorbornadienes, were well tolerated in the reaction with various anilines, and they generally delivered the corresponding chiral aryltetralin derivatives I [R1 = H, 6,7-di-Br, 6,7-di-Me, 5,8-di-OMe etc., R2 = H, o-Me m-OMe, p-OMe etc., R3 = R4 = Me, Et, X = NBoc, O, NTs, NCbz etc.] in good to excellent enantioselectivities. The reaction is speculated to proceed through the Friedel-Crafts reaction pathway.

Organic Letters published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Formula: C38H24F4O4P2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem