Category: 50593-65-2

Savini, Luisa et al. published their research in Farmaco in 1993 | CAS: 50593-65-2

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C11H8ClNO2

Synthesis of 4-quinolylazide derivatives and evaluation of their antitumor and antimicrobial activity was written by Savini, Luisa;Massarelli, Paola;Pellerano, Cesare. And the article was included in Farmaco in 1993.Formula: C11H8ClNO2 The following contents are mentioned in the article:

Synthesis and pharmacol. evaluation of a series of 4-quinolylazide derivatives are reported. These were screened against P388 lymphocytic leukemia in mice, but they were inactive. All the compounds were also tested for their antimicrobial activity against gram-pos., gram-neg. strains and fungi; only three derivatives exhibited poor activity. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Formula: C11H8ClNO2).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C11H8ClNO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Brindisi, Margherita et al. published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2016 | CAS: 50593-65-2

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C11H8ClNO2

Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors was written by Brindisi, Margherita;Brogi, Simone;Giovani, Simone;Gemma, Sandra;Lamponi, Stefania;De Luca, Filomena;Novellino, Ettore;Campiani, Giuseppe;Docquier, Jean-Denis;Butini, Stefania. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2016.Computed Properties of C11H8ClNO2 The following contents are mentioned in the article:

Metallo-β-lactamases (MBLs) represent one of the most important and widespread mechanisms of resistance to β-lactam antibiotics (including the life-saving carbapenems), against which no clin. useful inhibitors are currently available. Here, the authors report a structure-based high-throughput docking campaign on 3 clin.-relevant acquired MBLs (IMP-1, NDM-1 and VIM-2). The initial hit, NF 1810, was optimized providing the broad-spectrum inhibitor , which was able to potentiate the in vitro activity of cefoxitin on a VIM-2-producing Escherichia coli strain. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Computed Properties of C11H8ClNO2).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C11H8ClNO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Gemma, Sandra et al. published their research in Tetrahedron Letters in 2008 | CAS: 50593-65-2

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Computed Properties of C11H8ClNO2

Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives was written by Gemma, Sandra;Kukreja, Gagan;Tripaldi, Pierangela;Altarelli, Maria;Bernetti, Matteo;Franceschini, Silvia;Savini, Luisa;Campiani, Giuseppe;Fattorusso, Caterina;Butini, Stefania. And the article was included in Tetrahedron Letters in 2008.Computed Properties of C11H8ClNO2 The following contents are mentioned in the article:

Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. This paper describes the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Computed Properties of C11H8ClNO2).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Computed Properties of C11H8ClNO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Pellerano, C. et al. published their research in Farmaco, Edizione Scientifica in 1984 | CAS: 50593-65-2

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Synthesis and biological activities of new compounds having a 1,3-dioxol[4,5-g]quinoline structure was written by Pellerano, C.;Savini, L.. And the article was included in Farmaco, Edizione Scientifica in 1984.Category: dioxole The following contents are mentioned in the article:

Four substituted 1,3-dioxol[4,5-g]quinolines (I; R = OH, Cl, SH or NHHN2) were prepared by heat cyclization of Et β–(3,4-methylenedioxyphenylamino)crotonate  [91918-88-6], followed by substitution of the R groups. By reaction of I (R = NHNH2) with a wide variety of carbonyl compounds, 26 corresponding hydrazones (II) were obtained. All the compounds were tested for antimicrobial activity in vitro and antitumor activity (P388 lymphocytic leukemia) in mice. Most II had good activity against gram-pos. bacteria but not against gram-neg. bacteria, fungi, or Trichomonas vaginalis. I and II were inactive against the tumor. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Category: dioxole).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Kakadiya, Rajesh et al. published their research in Bioorganic & Medicinal Chemistry in 2010 | CAS: 50593-65-2

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Safety of 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline

Potent DNA-directed alkylating agents: Synthesis and biological activity of phenyl N-mustard-quinoline conjugates having a urea or hydrazinecarboxamide linker was written by Kakadiya, Rajesh;Dong, Huajin;Kumar, Amit;Narsinh, Dodia;Zhang, Xiuguo;Chou, Ting-Chao;Lee, Te-Chang;Shah, Anamik;Su, Tsann-Long. And the article was included in Bioorganic & Medicinal Chemistry in 2010.Safety of 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline The following contents are mentioned in the article:

A series of N-mustard-quinoline conjugates bearing a urea or hydrazinecarboxamide linker was synthesized for antitumor evaluation. The in vitro cytotoxicity studies revealed that compounds with hydrazinecarboxamide linkers were generally more cytotoxic than the corresponding urea counterparts in inhibiting human lymphoblastic leukemia and various solid tumor cell growths in culture. The therapeutic efficacy against human tumor xenografts in animal model was studied. It was shown that complete tumor remission in nude mice bearing human breast carcinoma MX-1 xenograft by 17a, i and 18c, d was achieved. In the present study, it was revealed that both linkers are able to lower the chem. reactive N-mustard pharmacophore and thus the newly synthesized conjugates possess a long half-life in rat plasma. Moreover, the new N-mustard derivatives are able to induce DNA crosslinking either by modified comet assay or by alk. agarose gel shift assay. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Safety of 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Safety of 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem