Category: 4360-63-8

Synthetic Route of C4H7BrO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Optimization studies for hydrothermal gasification of partially burnt wood from forest fires for hydrogen-rich syngas production using Taguchi experimental design. Author is Okolie, Jude A.; Nanda, Sonil; Dalai, Ajay K.; Kozinski, Janusz A..

Forest fires significantly affect the wildlife, vegetation, composition and structure of the forests. This study explores the potential of partially burnt wood recovered in the aftermath of a recent Canadian forest fire incident as a feedstock for generating hydrogen-rich syngas through hydrothermal gasification. Partially burnt wood was gasified in hydrothermal conditions to study the influence of process temperature (300-500 °C), residence time (15-45 min), feed concentration (10-20 wt%) and biomass particle size (0.13 mm and 0.8 mm) using the statistical Taguchi method. Maximum hydrogen yield and total gas yield of 5.26 mmol/g and 11.88 mmol/g, resp. were obtained under optimized process conditions at 500 °C in 45 min with 10 wt% feed concentration using biomass particle size of 0.13 mm. The results from the mean of hydrogen yield show that the contribution of each exptl. factors was in the order of temperature > feed concentration > residence time > biomass particle size. Other gaseous products obtained at optimum conditions include CO2 (3.43 mmol/g), CH4 (3.13 mmol/g) and C2-C4 hydrocarbons (0.06 mmol/g).

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Dioxole | C3H4O2 – PubChem

Application In Synthesis of 2-Bromomethyl-1,3-dioxolane. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Electrochemical Umpolung C-H Functionalization of Oxindoles. Author is Pastor, Miryam; Vayer, Marie; Weinstabl, Harald; Maulide, Nuno.

Herein, a general electrochem. method to access unsym. 3,3-disubstituted oxindoles I (R1 = Me, Ph, Bn, cyclopentyl, etc.; R2 = Me, phenylethyl, Bn, etc.) by direct C-H functionalization where the oxindole fragment behaves as an electrophile was reported. This Umpolung approach does not rely on stoichiometric oxidants and proceeds under mild, environmentally benign conditions. Importantly, it enables the functionalization of these scaffolds through C-O, and by extension to C-C or even C-N bond formation.

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Application In Synthesis of 2-Bromomethyl-1,3-dioxolane. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Iridium-catalyzed enantioselective allylic substitution with aqueous solutions of nucleophiles.

The iridium-catalyzed asym. allylic substitution under biphasic conditions is reported. This approach allows the use of various unstable and/or volatile nucleophiles including hydrazines, methylamine, t-Bu hydroperoxide, N-hydroxylamine, α-chloroacetaldehyde and glutaraldehyde. This transformation provides rapid access to a broad range of products from simple starting materials in good yields and up to >99% ee and 20:1 d.r.. Addnl., these products can be elaborated efficiently into a diverse set of cyclic and acyclic compounds, bearing up to four stereocenters.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Sulfide analogues of flupirtine and retigabine with nanomolar KV7.2/KV7.3 channel opening activity, published in 2019, which mentions a compound: 4360-63-8, Name is 2-Bromomethyl-1,3-dioxolane, Molecular C4H7BrO2, Synthetic Route of C4H7BrO2.

The potassium channel openers flupirtine and retigabine have proven to be valuable analgesics or antiepileptics. Their recent withdrawal due to occasional hepatotoxicity and tissue discoloration, resp., leaves a therapeutic niche unfilled. Metabolic oxidation of both drugs gives rise to the formation of electrophilic quinones. These elusive, highly reactive metabolites may induce liver injury in the case of flupirtine and blue tissue discoloration after prolonged intake of retigabine. We examined which structural features can be altered to avoid the detrimental oxidation of the aromatic ring and shift oxidation toward the formation of more benign metabolites. Structure-activity relationship studies were performed to evaluate the KV7.2/3 channel opening activity of 45 derivatives Sulfide analogs were identified that are devoid of the risk of quinone formation, but possess potent KV7.2/3 opening activity. For example, flupirtine analog 3-(3,5-difluorophenyl)-N-(6-(isobutylthio)-2-(pyrrolidin-1-yl)pyridin-3-yl)propanamide (48) has 100-fold enhanced activity (EC50=1.4 nM), a vastly improved toxicity/activity ratio, and the same efficacy as retigabine in vitro.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Sulfide analogues of flupirtine and retigabine with nanomolar KV7.2/KV7.3 channel opening activity, published in 2019, which mentions a compound: 4360-63-8, mainly applied to flupirtine retigabine potassium channel; KCNQ; KV7; flupirtine; retigabine; sulfides, Electric Literature of C4H7BrO2.

The potassium channel openers flupirtine and retigabine have proven to be valuable analgesics or antiepileptics. Their recent withdrawal due to occasional hepatotoxicity and tissue discoloration, resp., leaves a therapeutic niche unfilled. Metabolic oxidation of both drugs gives rise to the formation of electrophilic quinones. These elusive, highly reactive metabolites may induce liver injury in the case of flupirtine and blue tissue discoloration after prolonged intake of retigabine. We examined which structural features can be altered to avoid the detrimental oxidation of the aromatic ring and shift oxidation toward the formation of more benign metabolites. Structure-activity relationship studies were performed to evaluate the KV7.2/3 channel opening activity of 45 derivatives Sulfide analogs were identified that are devoid of the risk of quinone formation, but possess potent KV7.2/3 opening activity. For example, flupirtine analog 3-(3,5-difluorophenyl)-N-(6-(isobutylthio)-2-(pyrrolidin-1-yl)pyridin-3-yl)propanamide (48) has 100-fold enhanced activity (EC50=1.4 nM), a vastly improved toxicity/activity ratio, and the same efficacy as retigabine in vitro.

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1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromomethyl-1,3-dioxolane(SMILESS: BrCC1OCCO1,cas:4360-63-8) is researched.Name: (2R)-1-[(1R)-1-[Bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene. The article 《Iridium-catalyzed acid-assisted asymmetric hydrogenation of oximes to hydroxylamines》 in relation to this compound, is published in Science (Washington, DC, United States). Let’s take a look at the latest research on this compound (cas:4360-63-8).

Asym. hydrogenations are among the most practical methods for the synthesis of chiral building blocks at industrial scale. The selective reduction of an oxime to the corresponding chiral hydroxylamine derivative remains a challenging variant because of undesired cleavage of the weak nitrogen-oxygen bond. We report a robust cyclometalated iridium(III) complex bearing a chiral cyclopentadienyl ligand as an efficient catalyst for this reaction operating under highly acidic conditions. Valuable N-alkoxy amines can be accessed at room temperature with nondetected overredn. of the N-O bond [e.g., (E)-I → (S)-II (97%, 97.5:2.5 er)]. Catalyst turnover numbers up to 4000 and enantiomeric ratios up to 98:2 are observed The findings serve as a blueprint for the development of metal-catalyzed enantioselective hydrogenations of challenging substrates.

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HPLC of Formula: 4360-63-8. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Stereoselective total synthesis of diplodialide A. Author is Ramakrishna, Kolluri; Sreenivasulu, Reddymasu; Rao, Mandava Venkata Basaveswara; Vidavalur, Siddaiah; Reddy, Boggu Jagan Mohan.

An efficient stereoselective total synthesis of diplodialide A I was achieved from inexpensive and com. available starting material (R)-propylene oxide. This linear synthesis utilizes Wittig reaction, alkylation of 1,3-dithiane and Yamaguchi macrolactonization as key steps.

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Dioxole | C3H4O2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Modular Synthesis of Bicyclic and Tricyclic (Aza-) Arenes from Nucleophilic (Aza-)Arenes with Electrophilic Side Arms via [4+2] Annulation Reactions, the main research direction is bicyclic aza arene preparation; tricyclic aza arene preparation; enolizable carbonyl compound aza arene annulation scandium triflate catalyst.Recommanded Product: 4360-63-8.

An efficient strategy for the synthesis of bicyclic aza-arenes I [R1 = Me, Ph, 2-thienyl, etc.; R2 = Me, OEt, OBn, etc.; Ar = OMe, Cl, Ph, etc.] and tricyclic aza-arenes, e.g., II from a nucleophilic aza-arene with an electrophilic side arm was developed. The aza-arene precursor had both nucleophilic and electrophilic sites, which were fixed at a 1,4-distance. The bicyclic and tricyclic (aza-)arene products I and II were constructed via [4+2] annulation by using scandium(III) triflate as a catalyst and enolizable ketones or aldehydes as the counterpart reagents. A variety of six-membered carbocycles and heterocycles, such as indolizines, indoles, naphthalenes, carbazoles and pyrido[1,2-α]indoles, were successfully synthesized. Some one-pot sequential reactions were also developed, in which the 1,4-donor-acceptor precursors can be synthesized via oxidation of alcs. or a proper condensation reaction.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem