Category: 22353-34-0

Ding, Xiao; Dai, Xuedong; Long, Kai; Peng, Cheng; Andreotti, Daniele; Bamborough, Paul; Eatherton, Andrew J.; Edge, Colin; Jandu, Karamjit S.; Nichols, Paula L.; Philps, Oliver J.; Stasi, Luigi Piero; Wan, Zehong; Xiang, Jia-Ning; Dong, Kelly; Dossang, Pamela; Ho, Ming-Hsun; Li, Yi; Mensah, Lucy; Guan, Xiaoming; Reith, Alastair D.; Ren, Feng published an article about the compound: 5-Chloropyridin-3-amine( cas:22353-34-0,SMILESS:NC1=CC(=CN=C1)Cl ).Application of 22353-34-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:22353-34-0) through the article.

Leucine-rich repeat kinase 2 (LRRK2) has been suggested as a potential therapeutic target for Parkinson’s disease. Herein we report the discovery of 5-substituent-N-arylbenzamide derivatives as novel LRRK2 inhibitors. Extensive SAR study led to the discovery of compounds I, which demonstrated potent LRRK2 inhibition activity, high selectivity across the kinome, good brain exposure, and high oral bioavailability.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called The synthesis, structure-toxicity relationship of cisplatin derivatives for the mechanism research of cisplatin-induced nephrotoxicity, published in 2017-08-01, which mentions a compound: 22353-34-0, Name is 5-Chloropyridin-3-amine, Molecular C5H5ClN2, Synthetic Route of C5H5ClN2.

Cisplatin is a widely used antineoplastic drug, while its nephrotoxicity limits the clin. application. Although several mechanisms contributing to nephrotoxicity are reported, the direct protein targets are unclear. Herein the authors reported the synthesis of 29 cisplatin derivatives and the structure-toxicity relation (STR) of these compounds with MTT assay in human renal proximal tubule cells (HK-2) and pig kidney epithelial cells (LLC-PK1). To the best of the authors’ knowledge, this study represented the 1st report regarding the structure-toxicity relation (STR) of cisplatin derivatives The potency of biotin-pyridine conjugated derivative 3 met the requirement for target identification, and the preliminary chem. proteomics results suggested that it is a promising tool for further target identification of cisplatin-induced nephrotoxicity.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Yun, Fan; Cheng, Chunhui; Zhang, Jing; Li, Jingxuan; Liu, Xia; Xie, Rui; Tang, Pingwah; Yuan, Qipeng published the article 《Boric Acid Catalyzed Direct Amidation between Amino-Azaarenes and Carboxylic Acids》. Keywords: azaarylamide preparation green chem chemoselective; aminoazaarene carboxylic acid boric acid tetramethylpropanediamine catalyst amidation.They researched the compound: 5-Chloropyridin-3-amine( cas:22353-34-0 ).Computed Properties of C5H5ClN2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:22353-34-0) here.

A novel and facile boric acid-catalyzed direct amidation between amino-azaarene compounds and carboxylic acids was developed. The amidation proceeded cleanly and provided good to excellent yields of the desired amides. Boric acid is a green and inexpensive catalyst. It was also found that N,N,N’,N’-tetramethylpropane-1,3-diamine acted as an additive accelerating this boric acid-catalyzed amidation. A mixed acid anhydride was postulated to be the active intermediate responsible for this successful amidation. This direct amidation was an atom- and step-economical reaction.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Investigations on the isomerization of ring-substituted derivatives of 3-nitraminopyridines. I. Chloro-3-nitraminopyridines》. Authors are Czuba, Wladyslaw.The article about the compound:5-Chloropyridin-3-aminecas:22353-34-0,SMILESS:NC1=CC(=CN=C1)Cl).HPLC of Formula: 22353-34-0. Through the article, more information about this compound (cas:22353-34-0) is conveyed.

6-(m. 139°), 2- (m. 100-3°), 5- (m. 146°), and 4-Chloro-3-nitraminopyridine (m. 179°) (all with decomposition) heated to 40° in concentrated H2SO4 underwent isomerization to 6,6′-dichloro- (I) (m. 215-17°, yield 10%) and 6,6′-dichloro-2-nitro- (II) (m. 165°, 9%), 2,2′-dichloro- (III) (m. 237-9°, 26%), 5,5′-dichloro- 3, 3′-azopyridine (IV) (m. 183°, 16%) and 5-chloro-3-hydroxypyridine (m. 158°, 32%), and 4,4′-dichloro-3,3′-azopyridine (V) (m. 164°, 40%), resp. I, III, IV, and V with SnCl2, Sn, or NaSH gave the hydrazopyridines, m. 183-5°, 209°, 128-31°, and 172°, resp., yields 70-91%. Reduction of III yielded 6-chloro-2,3-diamino- and -3-aminopyridine. A new method of preparation of 3-amino-5-chloropyridine (VI) was described. Br (32 g.) dissolved in 25 g. NaOH, 50 ml. H2O, and 250 g. ice, 25.5 g. 5-chloronicotinic acid amide added, the mixture heated 0.5 hr. at 75°, the solution saturated with NaCl, extracted with Et2O, dried (K2CO3), and evaporated gave 83% VI, m. 82° (C6H6 + ligroine).

As far as I know, this compound(22353-34-0)HPLC of Formula: 22353-34-0 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Investigations on the isomerization of ring-substituted derivatives of 3-nitraminopyridines. I. Chloro-3-nitraminopyridines》. Authors are Czuba, Wladyslaw.The article about the compound:5-Chloropyridin-3-aminecas:22353-34-0,SMILESS:NC1=CC(=CN=C1)Cl).Synthetic Route of C5H5ClN2. Through the article, more information about this compound (cas:22353-34-0) is conveyed.

6-(m. 139°), 2- (m. 100-3°), 5- (m. 146°), and 4-Chloro-3-nitraminopyridine (m. 179°) (all with decomposition) heated to 40° in concentrated H2SO4 underwent isomerization to 6,6′-dichloro- (I) (m. 215-17°, yield 10%) and 6,6′-dichloro-2-nitro- (II) (m. 165°, 9%), 2,2′-dichloro- (III) (m. 237-9°, 26%), 5,5′-dichloro- 3, 3′-azopyridine (IV) (m. 183°, 16%) and 5-chloro-3-hydroxypyridine (m. 158°, 32%), and 4,4′-dichloro-3,3′-azopyridine (V) (m. 164°, 40%), resp. I, III, IV, and V with SnCl2, Sn, or NaSH gave the hydrazopyridines, m. 183-5°, 209°, 128-31°, and 172°, resp., yields 70-91%. Reduction of III yielded 6-chloro-2,3-diamino- and -3-aminopyridine. A new method of preparation of 3-amino-5-chloropyridine (VI) was described. Br (32 g.) dissolved in 25 g. NaOH, 50 ml. H2O, and 250 g. ice, 25.5 g. 5-chloronicotinic acid amide added, the mixture heated 0.5 hr. at 75°, the solution saturated with NaCl, extracted with Et2O, dried (K2CO3), and evaporated gave 83% VI, m. 82° (C6H6 + ligroine).

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

HPLC of Formula: 22353-34-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Chloropyridin-3-amine, is researched, Molecular C5H5ClN2, CAS is 22353-34-0, about First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-κB Activity As Novel Anticancer Agents. Author is Hamed, Mostafa M.; Darwish, Sarah S.; Herrmann, Jennifer; Abadi, Ashraf H.; Engel, Matthias.

The activation of the NF-κB transcription factor is a major adaptive response induced upon treatment with EGFR kinase inhibitors, leading to the emergence of resistance in nonsmall cell lung cancer and other tumor types. To suppress this survival mechanism, we developed new thiourea quinazoline derivatives that are dual inhibitors of both EGFR kinase and the NF-κB activity. Optimization of the hit compound, identified in a NF-κB reporter gene assay, led to compound 9b, exhibiting a cellular IC50 for NF-κB inhibition of 0.3 μM while retaining a potent EGFR kinase inhibition (IC50 = 60 nM). The dual inhibitors showed a higher potency than gefitinib to inhibit cell growth of EGFR-overexpressing tumor cell lines in vitro and in a xenograft model in vivo, while no signs of toxicity were observed An investigation of the mol. mechanism of NF-κB suppression revealed that the dual inhibitors depleted the transcriptional coactivator CREB-binding protein from the NF-κB complex in the nucleus.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

COA of Formula: C5H5ClN2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Chloropyridin-3-amine, is researched, Molecular C5H5ClN2, CAS is 22353-34-0, about The synthesis, structure-toxicity relationship of cisplatin derivatives for the mechanism research of cisplatin-induced nephrotoxicity.

Cisplatin is a widely used antineoplastic drug, while its nephrotoxicity limits the clin. application. Although several mechanisms contributing to nephrotoxicity are reported, the direct protein targets are unclear. Herein the authors reported the synthesis of 29 cisplatin derivatives and the structure-toxicity relation (STR) of these compounds with MTT assay in human renal proximal tubule cells (HK-2) and pig kidney epithelial cells (LLC-PK1). To the best of the authors’ knowledge, this study represented the 1st report regarding the structure-toxicity relation (STR) of cisplatin derivatives The potency of biotin-pyridine conjugated derivative 3 met the requirement for target identification, and the preliminary chem. proteomics results suggested that it is a promising tool for further target identification of cisplatin-induced nephrotoxicity.

There is still a lot of research devoted to this compound(SMILES：NC1=CC(=CN=C1)Cl)COA of Formula: C5H5ClN2, and with the development of science, more effects of this compound(22353-34-0) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Feng, Rui; Jie, Suyun; Braunstein, Pierre; Li, Bo-Geng published an article about the compound: 5-Chloropyridin-3-amine( cas:22353-34-0,SMILESS:NC1=CC(=CN=C1)Cl ).Name: 5-Chloropyridin-3-amine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:22353-34-0) through the article.

The ring-opening polymerization (ROP) of lactones is an effective method for the preparation of biocompatible and biodegradable aliphatic polyesters, for which the development of efficient organocatalysts with high activity and good controllability is highly desirable. A series of novel pyridyl-urea catalysts was synthesized and applied in the solvent-free ROP of lactones and trimethylene carbonate. Combined with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD), the pyridyl-urea/MTBD systems showed a fast and living/controlled behavior in the ROP, generating polymers with narrow mol. weight distributions. The influences of catalyst structure, type of base, pyridyl-urea/base ratio, feed ratio of monomer/initiator and reaction temperature on the catalytic properties were investigated. A possible mechanism was proposed on the basis of NMR titration and dilution experiments

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Winterton, Sarah E.; Capota, Emanuela; Wang, Xiaoyu; Chen, Hong; Mallipeddi, Prema L.; Williams, Noelle S.; Posner, Bruce A.; Nijhawan, Deepak; Ready, Joseph M. published an article about the compound: 5-Chloropyridin-3-amine( cas:22353-34-0,SMILESS:NC1=CC(=CN=C1)Cl ).Recommanded Product: 5-Chloropyridin-3-amine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:22353-34-0) through the article.

Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Unsaturated fatty acids are required for membrane integrity and for cell proliferation. For these reasons, inhibitors of SCD represent potential treatments for cancer. However, systemically active SCD inhibitors result in skin toxicity, which presents an obstacle to their development. We recently described a series of oxalic acid diamides that are converted into active SCD inhibitors within a subset of cancers by CYP4F11-mediated metabolism Herein, we describe the optimization of the oxalic acid diamides and related N-acyl ureas and an anal. of the structure-activity relationships related to metabolic activation and SCD inhibition.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Formula: C5H5ClN2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloropyridin-3-amine, is researched, Molecular C5H5ClN2, CAS is 22353-34-0, about Silver-Mediated Trifluoromethoxylation of (Hetero)aryldiazonium Tetrafluoroborates. Author is Yang, Yu-Ming; Yao, Jian-Fei; Yan, Wei; Luo, Zhuangzhu; Tang, Zhen-Yu.

Here we report a silver-mediated trifluoromethoxylation of (hetero)aryldiazonium tetrafluoroborates by converting an aromatic amino group into an OCF3 group. This method, which can be considered to be a trifluoromethoxylation variation of the classic Sandmeyer-type reaction, uses readily available aryl and heteroaromatic amines as starting materials and AgOCF3 as trifluoromethoxylating reagents. The broad substrate scope and simple, mild reaction condition made this transformation a valuable method in constructing aryl-OCF3 bonds.

There is still a lot of research devoted to this compound(SMILES：NC1=CC(=CN=C1)Cl)Formula: C5H5ClN2, and with the development of science, more effects of this compound(22353-34-0) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem