Yun, Fan; Cheng, Chunhui; Zhang, Jing; Li, Jingxuan; Liu, Xia; Xie, Rui; Tang, Pingwah; Yuan, Qipeng published the article 《Boric Acid Catalyzed Direct Amidation between Amino-Azaarenes and Carboxylic Acids》. Keywords: azaarylamide preparation green chem chemoselective; aminoazaarene carboxylic acid boric acid tetramethylpropanediamine catalyst amidation.They researched the compound: 5-Chloropyridin-3-amine( cas:22353-34-0 ).Computed Properties of C5H5ClN2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:22353-34-0) here.
A novel and facile boric acid-catalyzed direct amidation between amino-azaarene compounds and carboxylic acids was developed. The amidation proceeded cleanly and provided good to excellent yields of the desired amides. Boric acid is a green and inexpensive catalyst. It was also found that N,N,N’,N’-tetramethylpropane-1,3-diamine acted as an additive accelerating this boric acid-catalyzed amidation. A mixed acid anhydride was postulated to be the active intermediate responsible for this successful amidation. This direct amidation was an atom- and step-economical reaction.
When you point to this article, it is believed that you are also very interested in this compound(22353-34-0)Computed Properties of C5H5ClN2 and due to space limitations, I can only present the most important information.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem