Can You Really Do Chemisty Experiments About 22353-34-0

Compounds in my other articles are similar to this one(5-Chloropyridin-3-amine)Synthetic Route of C5H5ClN2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors, published in 2017-09-01, which mentions a compound: 22353-34-0, Name is 5-Chloropyridin-3-amine, Molecular C5H5ClN2, Synthetic Route of C5H5ClN2.

Leucine-rich repeat kinase 2 (LRRK2) has been suggested as a potential therapeutic target for Parkinson’s disease. Herein we report the discovery of 5-substituent-N-arylbenzamide derivatives as novel LRRK2 inhibitors. Extensive SAR study led to the discovery of compounds I, which demonstrated potent LRRK2 inhibition activity, high selectivity across the kinome, good brain exposure, and high oral bioavailability.

Compounds in my other articles are similar to this one(5-Chloropyridin-3-amine)Synthetic Route of C5H5ClN2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem