The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ) is researched.Safety of 2-Bromomethyl-1,3-dioxolane.He, Youliang; Wang, Xiaoming published the article 《Synthesis of Cyclic Amidines by Iridium-Catalyzed Deoxygenative Reduction of Lactams and Tandem Reaction with Sulfonyl Azides》 about this compound( cas:4360-63-8 ) in Organic Letters. Keywords: cyclic amidine diastereoselective preparation; iridium catalyst reductive deoxygenation lactam amidation sulfonyl azide. Let’s learn more about this compound (cas:4360-63-8).
An efficient and convenient synthesis of various cyclic amidines has been achieved via iridium-catalyzed deoxygenative reduction of lactams with a silane followed by a one-pot cycloaddition reaction with sulfonyl azides. Using the novel tandem procedure, a large array of cyclic amidines bearing various sized rings were synthesized in good yields from readily available lactams. This methodol. has been successfully utilized in the late stage diversification of complex architectures bearing a lactam moiety.
There is still a lot of research devoted to this compound(SMILES：BrCC1OCCO1)Safety of 2-Bromomethyl-1,3-dioxolane, and with the development of science, more effects of this compound(4360-63-8) can be discovered.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem