Analyzing the synthesis route of 144690-92-6

With the synthetic route has been constantly updated, we look forward to future research findings about Triphenyl methyl olmesartan,belong Dioxole compound

As a common heterocyclic compound, it belong Dioxole compound,Triphenyl methyl olmesartan,144690-92-6,Molecular formula: C48H44N6O6,mainly used in chemical industry, its synthesis route is as follows.,144690-92-6

Take 40g of compound 5, Add 80mL of methanol, 330 mL of ethyl acetate, Warmed to 45 , After 8 hours of reaction, Add 860mL water, Insoluble matter was removed by filtration, The filtrate was concentrated, In oily liquid, Acetonitrile, Stirred under a solid precipitation, filter, Washed with ethanol, 23.2 g of white solid was obtained, The yield was 83.1% The HPLC purity was 99.2%.

With the synthetic route has been constantly updated, we look forward to future research findings about Triphenyl methyl olmesartan,belong Dioxole compound

Reference£º
Patent; Disha Pharmaceutical Group Co., Ltd.; Zhang Zhaoxing; Zhang Hongqiang; Qin Litai; Li Wei; Li Zongwen; Xia Haijian; (6 pag.)CN103012382; (2016); B;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem