Month: February 2023

Base-mediated Nitrophenyl Reductive Cyclization for the Synthesis of Hexahydro-2,6-methano-1-benzazocines was written by Rodriguez, Laura G.;Delgado, Ana;Ciudad, Carlos J.;Noe, Veronique;Bonjoch, Josep;Bradshaw, Ben. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 126-39-6 This article mentions the following:

A Diels-Alder reaction leading to 4-nitrophenylcyclohexanones followed by a newly developed base-mediated reductive cyclization of the resulting ketone tethered to the nitrobenzene moiety gives access to the hexahydro-2,6-methano-1-benzazocine ring system present in several biol. interesting natural products such as aspernomine. The scope of the reaction was explored with eight substituted nitrobenzenes obtaining yields of up to 87%. The highest cytotoxicity was observed in benzazocine I, bearing an enone moiety, which was active against eight cancer cell lines. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6SDS of cas: 126-39-6).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 126-39-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Reactions of several monosaccharide-derived alcohols with p-acetamidobenzenesulfonyl azide and DBU was written by Sacui, Iulia A.;Norris, Peter. And the article was included in Tetrahedron Letters in 2011.Application of 14131-84-1 This article mentions the following:

Attempted diazo transfer to 1-O-(2-phenylacetyl)-2,3;5,6-di-O-isopropylidene-α-D-mannofuranose using p-acetamidobenzenesulfonyl azide (p-ABSA) and DBU as base affords 1-O-(2-diazo-2-phenylacetyl)-2,3;5,6-di-O-isopropylidene-α-D-mannofuranose in low yield along with 2,3;5,6-di-O-isopropylidene-α-D-mannofuranose, 1-azido-2,3;5,6-di-O-isopropylidene-β-D-mannofuranose, as well as the unreacted starting material. The azido sugar likely arises from α-mannofuranosyl sulfonate ester formation, through displacement of azide from p-ABSA by the sugar lactol, followed by stereospecific displacement by azide anion on the furanosyl sulfonate ester. This outcome has been studied further with the conditions being applied to several common monosaccharide derivatives Accessible substrates afford the azido sugar in an overall one-pot alc.-to-azide conversion, while hindered substrates yield the sulfonate esters. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Application of 14131-84-1).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 14131-84-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The catalytic system ‘Rhodamine B/additive’ for the chemical fixation of CO₂ was written by Wu, Feng-tian;Wu, Ling;Cui, Chun-na. And the article was included in Tetrahedron in 2021.Electric Literature of C8H10O5 This article mentions the following:

The catalytic system ‘Rhodamine B/additive’ was introduced to promote the CO₂ reactions. Various cyclic carbonates I (R¹ = Me, Et, Ph, 4-ClC₆H₄, etc.) in good to excellent yields under the catalysis of rhodamine B and TBAB have been synthesized. A variety of 2-oxazolidinone derivatives II (R¹ = Me, Ph; R² = H, Ph, 3-MeC₆H₄, etc.) were obtained in the presence of rhodamine B and DBU. In the experiment, the researchers used many compounds, for example, (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5Electric Literature of C8H10O5).

(2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Electric Literature of C8H10O5

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Dual Catalytic Strategy for Forging sp²-sp³ and sp³-sp³ Architectures via β-Scission of Aliphatic Alcohol Derivatives was written by Cong, Fei;Lv, Xin-Yang;Day, Craig S.;Martin, Ruben. And the article was included in Journal of the American Chemical Society in 2020.Related Products of 14131-84-1 This article mentions the following:

A dual platform for forging sp²-sp³ and sp³-sp³ carbon bonds via catalytic β-scission of aliphatic alc. derivatives with both aryl and alkyl halides is disclosed [e.g., I + p-(F₃C)C₆H₄Br → II (84%, 77% isolated) in presence of photocatalyst, Hantzsch ester under blue LED irradiation with Ni/(4,4′-di-tert-butyl-2,2′-bipyridyl)]. This protocol is distinguished by its wide substrate scope and broad applicability, even in the context of late-stage functionalization. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Related Products of 14131-84-1).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Related Products of 14131-84-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Molecular Weight Distribution of Two Types of Living Chains Formed during Nitroxide-Mediated Polymerization of Styrene was written by Kim, Kyoungho;Lee, Jieun;Cho, Hong Y.;Lee, Eun Ho;Lee, Seo-Hui;Chang, Taihyun;Jeon, Heung Bae;Paik, Hyun-jong. And the article was included in Macromolecular Rapid Communications in 2021.SDS of cas: 100-79-8 This article mentions the following:

Different types of polymer chains generated during the nitroxide-mediated polymerization of styrene are separated for the first time, and their mol. weight distribution (MWD) is investigated. Living and dead chains are monitored during the reaction; specifically, two types of living chains derived from the initiation of the alkoxyamine (R-T) and the self-initiation of styrene and dead chains present in the as-prepared polystyrene (PS). To distinguish between each polymer species, different numbers of hydroxyl groups are introduced onto the T and R groups of the alkoxyamine (one and two groups, resp.). Each living and dead chains is resolved according to the distinct number of hydroxyl groups on its chain-end using high-performance liquid chromatog. Mol. structures of the fractionated PS are characterized using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and ¹H NMR spectroscopy, and the results of which show two distinct initiation paths: one originating from R-T and the other from the self-initiation of styrene. Mol. weight and MWD are measured using size-exclusion chromatog. and reveal a narrow MWD for the living chains derived from R-T. Contrastingly, a broad and skewed MWD is observed for the other living chains derived from the self-initiation of styrene and the dead chains. In the experiment, the researchers used many compounds, for example, (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8SDS of cas: 100-79-8).

(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 100-79-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Oxidative deprotection of trimethylsilyl and tetrahydropyranyl ethers, acetals and ketals with N,N’-dibenzyl-1,4-diazoniabicyclo[2.2.2]octane peroxodisulfate under non-aqueous conditions was written by Alikarami, Mohammad;Abbasi, Zahra. And the article was included in Organic Chemistry: An Indian Journal in 2013.Computed Properties of C8H14O2 This article mentions the following:

An efficient and convenient conversion of trimethylsilyl and tetrahydropyranyl ethers, acetals and ketals to the corresponding carbonyl compounds with N,N’-dibenzyl-1,4-diazoniabicyclo[2.2.2]octane peroxodisulfate under non-aqueous conditions is described. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Computed Properties of C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Identification of 1,3-dioxolanes in coffee-like flavorings was written by Tateo, Fernando;Bononi, Monica;Lubian, Elisabetta;Martello, Silvia. And the article was included in Journal of High Resolution Chromatography in 1998.Safety of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol This article mentions the following:

Com. available coffee-like flavoring preparations, identifying certain dioxolane structures of particular interest were concerned. The research was carried out by GC/MS, and spectral characterization was performed of the compounds in question, and especially of the acetals and ketals produced from compounds with carbonyl functions and 1,2-propylene glycol. Some determinations by chiral gas chromatog. and by isotope ratio mass spectrometry (IRMS) were useful in improving the anal. characterization of certain dioxolanes. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Safety of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Safety of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

New aromatic azobis ethers obtained by condensation of sodium 4,4′-azodiphenoxide with monochloromethylated derivatives was written by Radu, Stelian;Borrell, Jose Ignacio;Gassiot i Matas, Miquel. And the article was included in Afinidad in 1995.Reference of 2568-30-1 This article mentions the following:

Seven new aromatic azobis ethers were synthesized by condensation of the sodium salt of 4,4′-dihydroxyazobenzene with following monochloromethylated derivatives: 1-chloro-2-(chloromethyl)benzene, 1-chloro-3-(chloromethyl)benzene, 1-chloro-4-(chloromethyl)benzene, 1-(chloromethyl)naphthalene, 2-(chloromethyl)-1H-isoindole-1,3(2H)dione, 2-chloromethyl-1,3-dioxolane and diphenylchloromethane. Behavior as liquid crystals was not detected for these compounds In the experiment, the researchers used many compounds, for example, 2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1Reference of 2568-30-1).

2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Reference of 2568-30-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Rh(III)-Catalyzed Tandem Reaction Access to (Quinazolin-2-yl)methanone Derivatives from 2,1-Benzisoxazoles and α-Azido Ketones was written by Liu, Shan;Wang, An-Jing;Li, Min;Zhang, Jing;Yin, Guo-Dong;Shu, Wen-Ming;Yu, Wei-Chu. And the article was included in Journal of Organic Chemistry in 2022.Safety of 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone This article mentions the following:

A Rh(III)-catalyzed tandem reaction for the synthesis of (quinazolin-2-yl)methanone derivatives was been explored from 2,1-benzisoxazoles and α-azido ketones. The transformation involved Rh(III)-catalyzed denitrogenation of α-azido ketones, aza-[4 + 2] cycloaddition, ring opening, and dehydration aromatization processes. Notably, the aza-[4 + 2] cycloaddition of an imine rhodium complex intermediate with 2,1-benzisoxazoles was key to this reaction. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Safety of 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Safety of 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Alternating Cationic Copolymerization of Vinyl Ethers and Aryl-Substituted Cyclic Acetals: Structural Investigation of Effects of Cyclic Acetals on Copolymerizability was written by Maruyama, Kazuya;Kanazawa, Arihiro;Aoshima, Sadahito. And the article was included in Macromolecules (Washington, DC, United States) in 2022.COA of Formula: C8H14O2 This article mentions the following:

The effects of the structural difference of cyclic acetals were investigated in the cationic copolymerization with vinyl monomers via the concurrent vinyl-addition and ring-opening mechanisms. A series of alkyl- and aryl-substituted cyclic acetals were successfully copolymerized with 2-chloroethyl vinyl ether (CEVE) under appropriate conditions. In particular, copolymerization of an aryl-substituted 2-(4-methoxyphenyl)-1,3-dioxolane (PMPDOL) with CEVE involved exclusive crossover reactions between PMPDOL and CEVE, resulting in alternating copolymers. Copolymerization of PMPDOL and other vinyl ethers and styrene derivatives also proceeded via the frequent crossover reactions, while the copolymerization of 2-methyl-1,3-dioxolane, a methyl-substituted counterpart of PMPDOL, with vinyl monomers except for CEVE proceeded negligibly. The difference in the substituents of cyclic acetals significantly affected the electronic and steric environments around the carbocation generated in the propagation reaction, which is related to the frequency of the crossover reaction. Acid hydrolysis of alternating copolymers resulted in complete degradation and selective generation of a single compound due to the periodic incorporation of acetal structures in the main chains, which supported the well-defined structure of copolymers. The monomer reactivity ratios were also consistent with the copolymerizability difference between the aryl- and alkyl-substituted cyclic acetals. The structure-polymerizability relationship of cyclic acetals in the copolymerization was discussed based on the reaction mechanism during the propagating reaction. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6COA of Formula: C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.COA of Formula: C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem