Month: February 2023

A new convenient method for the synthesis of chiral C₃-synthons was written by Emons, Carry H. H.;Kuster, Ben F. M.;Vekemans, Jozef A. J. M.;Sheldon, Roger A.. And the article was included in Tetrahedron: Asymmetry in 1991.Safety of (R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid This article mentions the following:

Routes are described for the facile preparation of protected optically pure D– and L-glyceric acid, e.g. I [R = Me, RR = (CH₂)₅], starting from D-mannitol, D-isoascorbic acid, and L-ascorbic acid. The key step is a ruthenium catalyzed oxidative cleavage of the vicinal diols, e.g. II, or the α-hydroxy acids, e.g. III. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid (cas: 114746-70-2Safety of (R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid (cas: 114746-70-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Safety of (R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Design of hybrid nonisocyanate polyurethane coatings for advanced ambient temperature curing applications was written by Asemani, Hamidreza;Zareanshahraki, Forough;Mannari, Vijay. And the article was included in Journal of Applied Polymer Science in 2019.Related Products of 13818-44-5 This article mentions the following:

This study is focused on development of environmentally benign, two component, high solid, nonisocyanate Polyurethane (NIPU) coatings through a novel route based on cyclic carbonate/amine chem. Cyclic carbonates are synthesized and reacted with an excess amount of amine to yield polyurethane polyamines (PUPAs). Coatings are then prepared by using stoichiometric proportions of PUPAs and aliphatic epoxies as crosslinkers and their coating properties are studied. Results reveal that by proper design of NIPU oligomers-functional group content, backbone structure, and mol. weight (M_n)-coatings with outstanding performance features such as low temperature flexibility and resistance to chems. can be obtained and selected coatings containing PUPA with M_n = 1480 and 1:1.5 mol ratio of low-mol.-weight amine exceed the performance of a conventional isocyanate-based reference sample. Elimination of isocyanates, substantially reduced volatile organic compounds as well as fast ambient curing, make these polyurethane coatings a promising alternative for various industrial applications. © 2018 Wiley Periodicals, Inc.J. Appl. Polym. Sci. 2018, 9999, 47266. In the experiment, the researchers used many compounds, for example, (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5Related Products of 13818-44-5).

(2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Related Products of 13818-44-5

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Correlation between bond dissociation energies and spin distribution for the radicals of ethers: A DFT study was written by Przybylak, Katarzyna R.;Cronin, Mark T. D.. And the article was included in Journal of Molecular Structure: THEOCHEM in 2010.SDS of cas: 126-39-6 This article mentions the following:

The bond dissociation energy (BDE) of the C-H bond at the α-position of 43 ethers was examined in terms of the ability of the ether to form peroxide. D. functional theory (DFT) calculations, based on the B3LYP level, were performed to determine essential factors governing the thermochem. stabilization of the radicals. Anal. of the structural properties of the radical species suggested that hyperconjugation, resonance stabilization and ring strain are the main features responsible for thermochem. stability. These effects are well reflected in the spin distribution in the radical species, which assists in the understanding of the trend of BDEs for the ethers. A good correlation was obtained between BDE and spin distribution for the whole set of ethers. Improved correlations were obtained by splitting the data set into subcategories based on structural properties, i.e. saturated acyclic ethers, polyethers and 5-membered cyclic ethers. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6SDS of cas: 126-39-6).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 126-39-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Facile carbohydrate-mimetic modifications of poly(ethylene imine) carriers for gene delivery applications was written by Englert, Christoph;Fevre, Mareva;Wojtecki, Rudy J.;Cheng, Wei;Xu, Qingxing;Yang, Chuan;Ke, Xiyu;Hartlieb, Matthias;Kempe, Kristian;Garcia, Jeannette M.;Ono, Robert J.;Schubert, Ulrich S.;Yang, Yi Yan;Hedrick, James L.. And the article was included in Polymer Chemistry in 2016.Synthetic Route of C12H20O6 This article mentions the following:

Com.-available linear and branched PEIs (LPEI and BPEI) were chem.-modified with carbohydrates and carbohydrate-mimetics to improve biocompatibility. Hydroxyl moieties were installed in a close proximity via reaction of PEI’s amines with paraformaldehyde (pF) or glycidol. Mixing PEI with pF led to the formation of hemiaminal moieties as well as N-methylation of the backbone through an Eschweiler-Clarke-type rearrangement. The amount of attached hydroxyl groups depended on the initial amount of pF and the results were in agreement with NMR studies on model reactions with primary and secondary amines. The primary amines of BPEI triggered the ring-opening of glycidol and sugar-containing epoxides, in methanol and at room temperature PEI chains modified with pF displayed the same cytotoxicity as the parent polymer, unless a sufficient amount of pF was added to trigger N-methylation of the backbone. In contrast, glycidol and sugar-functionalized BPEIs exhibited lower toxicity but similar (if not higher) transfection efficiency as compared to unmodified BPEI. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Synthetic Route of C12H20O6).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C12H20O6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The microwave synthesis of cyclohexanone glycol ketal catalyzed by activated carbon supported p-toluene sulfonic acid was written by Zhang, Ai-Hua;Yin, Du-Lin;Liu, Wen-Ping;Peng, Zhi-Yuan. And the article was included in Guangpu Shiyanshi in 2009.Synthetic Route of C8H14O2 This article mentions the following:

Cyclohexanone glycol ketal was synthesized from cyclohexanone and glycol using activated carbon supported p-toluene sulfonic acid as heterogeneous catalyst without solvent under microwave irradiation The effects of different factors such as mole ratio of reactants, catalyst dosage, microwave irradiation power, microwave irradiation time on the yield of cyclohexanone glycol ketal were carefully investigated. The activated carbon supported p-toluene sulfonic acid exhibited excellently catalytic activity. The best reaction conditions were as follows: the amount of cyclohexanone 0.2 mol, n(cyclohexanone):n(glycol)=1:1.6, the dosage of catalyst was 0.75% of the total mass of the reactants, microwave irradiation power 450W and radiation time 4min. Under this condition, the yield of cyclohexanone glycol ketal was up to 76.7%. The catalyst can be repeatedly used for six times without losing its catalytic activity. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Synthetic Route of C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Synthetic Route of C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Studies Toward the Enantiospecific Total Synthesis of Rhodexin A was written by Jung, Michael E.;Guzaev, Mikhail. And the article was included in Journal of Organic Chemistry in 2013.COA of Formula: C6H12O2 This article mentions the following:

Studies toward the enantiospecific total synthesis of rhodexin A via a very hindered inverse electron demand Diels-Alder reaction are described. The C8-diastereomer of the fully elaborated tetracyclic core of rhodexin A, I, was prepared in good yield and excellent selectivity using as the key step the stepwise Diels-Alder reaction of the very hindered dienone II and the silyl enol ether III catalyzed by the very strong Lewis acid, dimethylaluminum triflimide. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6COA of Formula: C6H12O2).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.COA of Formula: C6H12O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The effect of nutmeg essential oil constituents on Novikoff hepatoma cell viability and communication through Cx43 gap junctions was written by Mickus, Rokas;Janciuke, Gintare;Raskevicius, Vytautas;Mikalayeva, Valeryia;Matulyte, Inga;Marksa, Mindaugas;Maciunas, Kestutis;Bernatoniene, Jurga;Skeberdis, Vytenis Arvydas. And the article was included in Biomedicine & Pharmacotherapy in 2021.Category: dioxole This article mentions the following:

Essential oils from plants are a potential source of mols. having anti-inflammatory, anticancer, cardiotropic, and other activities. However, most of these effects lack mechanistic explanations and structure-activity relationship testing. In the present study, we: (1) identified the nutmeg essential oil (NEO) composition; (2) using mol. docking, we determined the putative regulatory binding sites on the connexin 43 (Cx43) that is responsible for gap junction-dependent intercellular communication (GJIC) in the majority of tissues; (3) examined the effect of NEO and its three constituents – sabinene, α-pinene, and α-copaene – on GJ conductance and gating in Novikoff cells expressing endogenous Cx43; and (4) verified whether NEO effects on GJIC correlated with its action on Novikoff cell viability, proliferation, and colony formation capability. Our results revealed NEO and its constituents as potent and efficient Cx43 GJ inhibitors acting by slow gating mechanism. In addition, NEO reduced Novikoff hepatoma cell viability, proliferation, and colony formation capability; however, this was achieved at higher doses and was unrelated to its effects on GJIC. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Category: dioxole).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Ruthenium(II)biscarboxylate-Catalyzed Hydrogen-Isotope Exchange by Alkene C-H Activation was written by Bechtoldt, Alexander;Ackermann, Lutz. And the article was included in ChemCatChem in 2019.Name: 2-Bromomethyl-1,3-dioxolane This article mentions the following:

Ruthenium(II) biscarboxylate catalysis enabled efficient hydrogen isotope exchange of acrylic C-H bonds with user-friendly D₂O. The C-H labeling was characterized by excellent positional selectivity and a broad functional group tolerance. The deuteration was successfully conducted on 55 mmol scale with TONs of >1000, while mechanistic studies provided insights into ruthenium(II) oxidase catalysis. The obtained deuterated alkenes enabled the synthesis of labeled standards for mass spectrometry of irradiated foodstuffs. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Name: 2-Bromomethyl-1,3-dioxolane).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Name: 2-Bromomethyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and biological screening of S-substituted derivatives of 5-{1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl}-1,3,4-oxadiazol-2-yl sulfide was written by Nafeesa, Khadija;Aziz-ur-Rehman;Abbasi, M. Athar;Siddiqui, Sabahat Z.;Rasool, Shahid;Hussain, Ghulam;Ahmed, Irshad. And the article was included in Asian Journal of Chemistry in 2015.Electric Literature of C4H7BrO2 This article mentions the following:

In present research, a novel series of S-substituted derivatives of 5-[1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl]-1,3,4-oxadiazole-2-thiol I [R = (CH₂)₂Br, i-Pr, s-Bu, etc.] were synthesized by a multistep protocol starting from Et piperidine-3-carboxylate, which reacted with (4-chlorobenzene)sulfonyl chloride. The resulting Et 1-[(4-chlorophenyl)sulfonyl]piperidine-3-carboxylate was subsequently converted into its corresponding carbohydrazide and then to the 2,5-disubstituted-1,3,4-oxadiazole by intermol. cyclization. The compound 5-[1-(4-chlorophenylsulfonyl)-3-piperidinyl]-1,3,4-oxadiazole-2-thiol was derivatized by different alkyl halides. All of the synthesized compounds were screened for antibacterial activity and enzyme inhibition potential against lipoxygenase enzyme. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Electric Literature of C4H7BrO2).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C4H7BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Daphniphyllum alkaloids. 10. Classical total synthesis of methyl homodaphniphyllate was written by Heathcock, Clayton H.;Davidsen, Steven K.;Mills, Sander G.;Sanner, Mark A.. And the article was included in Journal of Organic Chemistry in 1992.Application of 84764-41-0 This article mentions the following:

(±)-Me homodaphniphyllate (I) was prepared from the keto acid II in 15 steps via lactam III and tetracyclic ketal IV in 1.1% overall yield. In the experiment, the researchers used many compounds, for example, 2-(2-(2-Methyl-1,3-dioxolan-2-yl)ethyl)isoindoline-1,3-dione (cas: 84764-41-0Application of 84764-41-0).

2-(2-(2-Methyl-1,3-dioxolan-2-yl)ethyl)isoindoline-1,3-dione (cas: 84764-41-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application of 84764-41-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem