Month: February 2023

Mass spectrometry of the acetal derivatives of selected generally recognized as safe listed aldehydes with ethanol, 1,2-propylene glycol and glycerol was written by Woelfel, Keith;Hartman, Thomas G.. And the article was included in ACS Symposium Series in 1998.Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol This article mentions the following:

The FEMA-GRAS list offers flavor chemists a repertoire of nearly 2000 chems. for use in compounding natural and synthetic flavors for the U.S. marketplace. Aldehydes constitute an important class of these potential flavorants and are widely utilized to impart specific nuances. Alcs. such as ethanol, 1,2-propylene glycol and glycerol are commonly employed as solvents in compounded flavor systems due to their low odor and miscibility in a wide range of aqueous and organic matrixes. However, alcs. and aldehydes react rapidly under anhydrous conditions to form acetal derivatives which often possess different sensory properties. This well known reaction is reversible and its equilibrium is influenced by time, temperature, pH and moisture content. Mass spectra of acetals are currently under represented in com. databases and few literature references are available. Our investigation involved a systematic mass spectrometric study of the acetal derivatives of selected GRAS aldehydes reacted with ethanol, 1,2-propylene glycol and glycerol. Aldehydes from different chem. classes representing saturated and unsaturated aliphatics, aromatics, heterocyclics, terpenoids and others were included for characterization. The corresponding acetals were synthesized, analyzed by GC-MS in electron ionization mode and their retention indexes on a non-polar (polydimethylsiloxane) capillary column were determined A database of mass spectra was produced which includes many previously unreported species. In total, over 60 individual mass spectra were recorded. The characteristic mass spectral fragmentation pathways for each class of acetal are described. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and application of nanoporous triple-shelled CuAl₂O₄ hollow sphere catalyst for atmospheric chemical fixation of carbon dioxide was written by Heydari, P.;Hafizi, A.;Rajabzadeh, M.;Karimi, M.;Khalifeh, R.;Rahimpour, M. R.. And the article was included in Journal of the Taiwan Institute of Chemical Engineers in 2020.Recommanded Product: (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate This article mentions the following:

Herein, a copper-alumina spinel hollow sphere with a triple-shell structure developed and applied as a novel catalyst for the cycloaddition of CO₂ at atm. pressure. Different operating conditions such as reaction temperature, various solvents and reaction time were studied in this reaction. Besides, different epoxides were converted into corresponding substituted dioxolanones I [R = CH₂Cl, Ph, CH₂OC₆H₅, etc.] at 80°C, under bubbling of CO₂ at atm. pressure, a catalyst loading of 3 weight% and a reaction time of 24 h with isolated yields up to 100%. In addition, the kinetics of the reaction was investigated at different reaction temperatures by calculating the reaction rate constant and activation energy (based on the Arrhenius equation). The nanoporous triple-shell CuAl₂O₄ hollow microspheres reduce the mass transfer path of different reactant and product mols. along with better accessibility of interior active sites that improved the catalytic efficiency with suitable activity and remarkable cycling stability. In the experiment, the researchers used many compounds, for example, (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5Recommanded Product: (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate).

(2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Analysis of volatile components in Asarum heterotropoides by HS-SPME/GC-MS was written by Wang, Feng;Li, Nan;Li, Xue;Zhong, Lingyan;Huang, Zetian;Hu, Ping. And the article was included in Riyong Huaxue Gongye in 2021.Quality Control of 6-Allyl-4-methoxybenzo[d][1,3]dioxole This article mentions the following:

Asarum is a kind of commonly used traditional Chinese medicine, and volatile oil is the main material basis for its efficacy. In traditional studies, the volatile oil is extracted by steam distillation and analyzed by GC-MS. Although the extraction method is easy to operate and has low cost, it is time-consuming, large sample consumption, high extraction temperature and easy thermal decomposition of active components. Moreover, xylene is often added in this method to promote the stratification of volatile oil, which brings great interference to the subsequent GC-MS anal. and component identification of volatile oil. Therefore, Solid Phase microextraction (SPME) technol. that integrates extraction, purification, enrichment, and sampling functions was used to analyze the volatile oil of Asarum for the first time. The HS-SPME/GC-MS method was established to analyze Asarum heterotropoides, and the volatile components were identified by the NIST spectral library search and retention index. A total of 68 components were identified from the volatile oil of Asarum heterotropoides from 6 origins. The relative content of Me eugenol was the highest among the volatile components with peak area percentages ranging from 17.20% to 33.80%. The application of HS-SPME/GC-MS method to the study of the volatile components in Asarum heterotropoides can reflect the overall differences, and the method is simple and rapid, providing new ideas for the quality evaluation of Asarum heterotropoides. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Quality Control of 6-Allyl-4-methoxybenzo[d][1,3]dioxole).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Quality Control of 6-Allyl-4-methoxybenzo[d][1,3]dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Glycidyl Methacrylate Copolymers Modified with CO₂ was written by Yadollahi, M.;Bouhendi, H.;Zohuriaan-Mehr, M. J.;Farhadnejad, H.;Kabiri, K.;Mirabedini, S. M.. And the article was included in Soft Materials in 2013.SDS of cas: 13818-44-5 This article mentions the following:

Functional acrylic resin based on the terpolymer of Bu acrylate (BA)-Me methacrylate (MMA)-glycidyl methacrylate (GMA) was prepared The terpolymer was treated with CO2 gas flow in the presence of cetyltrimethyl ammonium bromide as a catalyst. In terms of the carbonation reaction time, poly(MMA-co-BA-co-GMA-co-2-oxo-1,3-dioxolane-4-yl-Me methacrylate) was prepared in various yields of CO₂ fixation (>90%). Phys., mech., and thermal properties of cured and uncured films were investigated. It was found that, for both cured and uncured films, the mech. properties were improved by increasing carbonation yield. However, their thermal resistance was decreased. In the experiment, the researchers used many compounds, for example, (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5SDS of cas: 13818-44-5).

(2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 13818-44-5

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Nickel-Catalysed Allylboration of Aldehydes was written by Dennis, Francesca M.;Robertson, Craig C.;Partridge, Benjamin M.. And the article was included in Synthesis in 2020.Category: dioxole This article mentions the following:

A nickel catalyst for the allylboration of aldehydes RCHO (R = 4-chlorophenyl, Ph, pyridin-2-yl, cyclohexyl, 2-phenylethane-1-yl, etc.) is reported, facilitating the preparation of anti-homoallylic alcs. RCH(OH)CH(C₆H₅)CH=CH₂ in high diastereoselectivity. The observed diastereoselectivities and NMR experiments suggest that allylation occurs through a well-defined six-membered transition state, with nickel acting as a Lewis acid. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8Category: dioxole).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

BF₃·SiO₂-catalyzed one-pot synthesis of α-aminophosphonates in ionic liquid and neat conditions was written by Reddy, Mudumala Veeranarayana;Dindulkar, Someshwar D.;Jeong, Yeon Tae. And the article was included in Tetrahedron Letters in 2011.SDS of cas: 1544-85-0 This article mentions the following:

α-Aminophosphonates were synthesized in a simple and efficient method from the three-component condensation reaction of 5-amino 2,2-difluoro-1,3-benzodioxole, aromatic aldehydes, and di-Et phosphite by silica-supported boron trifluoride (BF₃·SiO₂) in ionic liquid ([bmim][HCl]) under solvent-free conditions at room temperature in good to excellent yields and short reaction times. The catalyst can be recovered and reused for several times without any significant loss of activity. It was observed that a homogeneous reaction medium proved beneficial for the yield of the reaction. In the experiment, the researchers used many compounds, for example, 2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0SDS of cas: 1544-85-0).

2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.SDS of cas: 1544-85-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Palladium Nanoparticles-Catalyzed Synthesis of Indanone Derivatives via Intramolecular Reductive Heck Reaction was written by Parveen, Naziya;Sekar, Govindasamy. And the article was included in Advanced Synthesis & Catalysis in 2019.Product Details of 28657-75-2 This article mentions the following:

An efficient protocol for the straightforward, single-step synthesis of 3-aryl-1-indanones I (R¹ = H, 6-Br, 6-Ph, 6-PhCC, 5,6-OCH₂O; R² = Ph, 4-MeOC₆H₄, 3-furyl, 2-indolyl, etc.) from 2′-iodochalcones II via reductive Heck reaction using phosphine free, stable and reusable binaphthyl stabilized palladium nanoparticle (Pd-BNP) as a catalyst is described. An immense array of indanones I using both electron-rich and electron-deficient 2′-iodochalcones was synthesized. Further derivatization of the indanone I (R¹ = H; R² = Ph) was achieved successfully. The heterogeneous nature of the Pd-BNP was validated by centrifugation test and mercury poisoning experiment Pd-BNP was successfully recycled up to 5 cycles without any significant loss in reaction yield and particle size of nanoparticles was confirmed by TEM anal. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Product Details of 28657-75-2).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 28657-75-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Chemical reactivity and safener activity of acetal compounds was written by Ekler, Zsigmond;Dutka, Ferenc. And the article was included in Zeitschrift fuer Naturforschung, C: Journal of Biosciences in 1991.SDS of cas: 2568-30-1 This article mentions the following:

The chem. reactivity of acetamide-type compounds as well as their safener activity against thiocarbamate herbicides change with the number of chlorine substituents in the order: nonchlorinated < monochloro < dichloro. Several compounds of another chem. group, acetal (e.g., MG-191, 2-dichloromethyl-2-methyl-1,3-dioxolane), are also effective safeners for thiocarbamate herbicides. According to growthroom studies, the safener activity of acetals also increases with increasing chlorine content up to two chlorine atoms on the same carbon. A number of differently chlorinated acetals were synthesized and their acid-catalyzed hydrolysis rate determined in order to establish a relationship between their bioactivity and chem. reactivity. The hydrolysis rate order of acetals (nonchlorinated > monochloro > dichloro) is the opposite of that found for acetamides. Thus, safener activity of acetals increases with decreasing chem. reactivity. The opposite reactivity order of acetamides and acetals can be explained by the different mechanisms of their hydrolysis. Dichloroacetals are not effective safeners without further modification. In plants, however, they may be activated by a nonhydrolytic pathway. In the experiment, the researchers used many compounds, for example, 2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1SDS of cas: 2568-30-1).

2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.SDS of cas: 2568-30-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

eCF309: a potent, selective and cell-permeable mTOR inhibitor was written by Fraser, Craig;Carragher, Neil O.;Unciti-Broceta, Asier. And the article was included in MedChemComm in 2016.COA of Formula: C4H7BrO2 This article mentions the following:

Kinase inhibitors capable of blocking the phosphorylation of protein substrates with high selectivity are essential to probe and elucidate the etiol. role of such mols. and their signalling pathways. By addressing these biochem. questions in disease relevant cell-based and in vivo models, strong pharmacol. evidence can be generated towards validating or disproving a target hypothesis. Pharmacol. studies can also provide fundamental information to identify appropriate biomarkers and rational drug combination strategies and thereby facilitate clin. translation. However, due to the high number of kinases encoded by the human genome (>500) and their highly conserved catalytic domains, the development of such an elite class of inhibitors-a.k.a. high-quality chem. probes-represents a major challenge. Through a ligand-based inhibitor design, focused library synthesis and phenotypic screening to prioritize compounds with potent cell activity, we recently identified a cell cycle inhibitor with micromolar potency that inhibits mTOR kinase activity. Following a rapid lead optimization campaign, we report the development of eCF309, an mTOR inhibitor displaying low nanomolar potency both in vitro and in cells and an excellent selectivity profile (S-score (35%) = 0.01 at 10 μM). In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8COA of Formula: C4H7BrO2).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.COA of Formula: C4H7BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of acetals and ketals catalyzed by phosphotungstic acid supported on activated carbon was written by Yang, Shui-jin;Du, Xin-xian;Lu, Bao-lan. And the article was included in Beijing Huagong Daxue Xuebao, Ziran Kexueban in 2005.SDS of cas: 126-39-6 This article mentions the following:

Catalytic activities of the active carbon supported with phosphotungstic acid were reported for synthesizing 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane, 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane, cyclohexanone ethylene ketal, cyclohexanone 1,2-propanediol ketal, butanone ethylene ketal, butanone 1,2-propanediol ketal, 2-phenyl-1,3-dioxolane, 4-methyl-2-phenyl-1,3-dioxolane, 2-propyl-1,3-dioxolane,, and 4-methyl-2-propyl-1,3-dioxolane. It is demonstrated that the active carbon supported with phosphotungstic acid is an excellent catalyst. Various factors concerned in these reactions were investigated. The optimum conditions are found, i.e., the molar ratio of aldehyde/ketone to glycol 1/1.5, the mass percent of the catalyst used to the reactants 1.0%, and the reaction time 1 h. Under these conditions, the yield of 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane is 76.4%, and 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane 75.8%, the yield of cyclohexanone ethylene ketal 70.8%, and cyclohexanone 1,2-propanediol ketal 83.3%, the yield of butanone ethylene ketal 60.0%, and butanone 1,2-propanediol ketal 84.6%, the yield of 2-phenyl-1,3-dioxolane 83.0%, and 4-methyl-2-phenyl-1,3-dioxolane 81.3%, the yield of 2-propyl-1,3-dioxolane 91.4%, and 4-methyl-2-propyl-1,3-dioxolane 95.4%. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6SDS of cas: 126-39-6).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 126-39-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem