Month: February 2023

Resolution of alkyl pyridyl sulfoxides by complexation with a chiral host compound derived from tartaric acid was written by Zhu, Jin;Qin, Yong;He, Ze;Fu, Fang-Min;Zhou, Zhong-Yuan;Deng, Jin-Gen;Jiang, Yao-Zhong;Chau, Tay-Yuan. And the article was included in Tetrahedron: Asymmetry in 1997.Reference of 93379-49-8 This article mentions the following:

Alkyl pyridyl sulfoxides I (R = Me, Et) were prepared in high enantiomeric excess by resolution through inclusion complexation with a chiral host compound, (2R,3R)- or (2S,3S)-(-)-trans-4,5-bis(hydroxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane (II). The X-ray crystallog. structure anal. of complex (R,R)-(-)-II with (R)-(-)-I (R = Et) is reported. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8Reference of 93379-49-8).

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 93379-49-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Ni-Al Bimetallic Catalyzed Enantioselective Cycloaddition of Cyclopropyl Carboxamide with Alkyne was written by Liu, Qi-Sheng;Wang, De-Yin;Yang, Zhi-Jun;Luan, Yu-Xin;Yang, Jin-Fei;Li, Jiang-Fei;Pu, You-Ge;Ye, Mengchun. And the article was included in Journal of the American Chemical Society in 2017.Product Details of 93379-49-8 This article mentions the following:

A Ni-Al bimetallic catalyzed enantioselective cycloaddition reaction of cyclopropyl carboxamides with alkynes was developed. A series of cyclopentenyl carboxamides were obtained in up to 99% yield and 94% ee. The bifunctional-ligand-enabled bimetallic catalysis proved to be an efficient strategy for the C-C bond cleavage of unreactive cyclopropanes. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8Product Details of 93379-49-8).

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Product Details of 93379-49-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthetic study of marine diterpenoid aberrarone: stereocontrolled construction of tetracyclic framework was written by Kobayashi, Toyoharu;Tokumoto, Kasumi;Tsuchitani, Yuki;Abe, Hideki;Ito, Hisanaka. And the article was included in Tetrahedron in 2015.Recommanded Product: 2-Bromomethyl-1,3-dioxolane This article mentions the following:

Highly stereocontrolled synthesis of the tetracyclic framework of the marine diterpenoid aberrarone (I), which possesses antimalarial activity against a chloroquine-resistant strain of Plasmodium, has been accomplished. A key feature of the synthesis is the complete stereocontrolled construction of C- and D-ring using stereoselective 1,4-addition followed by intramol. aldol reaction protocol. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Recommanded Product: 2-Bromomethyl-1,3-dioxolane).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 2-Bromomethyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Derivatives of cyclic acetals. I. Cyclic chloro acetals and their derivatives was written by Yasnitskii, B. G.;Sarkisyants, S. A.;Ivanyuk, E. G.. And the article was included in Zhurnal Obshchei Khimii in 1964.COA of Formula: C4H7ClO2 This article mentions the following:

The sulfonated polystyrene ion-exchange resin (KU-1) was found to be an effective agent for formation of cyclic acetals of ClCH₂CHO. Thus, heating 1 kg. 98% glycerol with 475 g. (ClCH₂CHO)_2.H₂O and 28 g. KU-1 resin 10-12 h. at 80-90° gave 96% glycerol α,β-chloroacetal, b₉ 125-30°. Similarly were prepared 60-86% cyclic acetals of ClCH₂CHO and ethylene glycol (I), propylene glycol, α-chloroglycerol (II), diethylene glycol, pentaerythritol, mannitol, and sorbitol. The cyclic acetal (IIa) of ClCH₂CHO and I added slowly to tert-BuOK in tert-BuOH and then heated 2 h. at 80-5° gave 85% III, b₉ 56-7°, d₂₀ 1.0096, n²⁰_D 1.4350. Similarly were prepared 52% IV, b. 127-8°, -, 1.4465 (at 25°); 75.2% V, b. 169-70°, 1.2346, 1.4530; and 40% VI, m. 52°. To 25 g. K in 500 g. BuOH was added 78.3 g. IIa (b₉ 52-3°, 1.2475, 1.4474) and the mixture kept 10-12 h. at 110-20° to give 62.5% VII, b₅ 47-9°, 0.9892, 1.4225, also formed from III and KOH in BuOH. Similarly was prepared 85% the ethoxy analog. The acetals based on ketene readily formed glassy polymers. The following constants were given for the cyclic chloroacetals (alc., b.p., d₂₀, and n²⁰_D given): glycerol, b₀ 125-30°, 1.3245, 1.475; propylene glycol, b₅ 45-6°, 1.1597, 1.4420; α-chloroglycerol, b₄ 82-3°, 1.3498, 1.4750; diethylene glycol, b₅ 115-18° (m. 45-6°), 1.1670, 1.4562; pentaerythritol, – (m. 92°), -, -; mannitol, b_·1-0.2 195-200°, 1.4473, 1.5048; sorbitol, b_0.05 219-20°, 1.4484, 1.5096. In the experiment, the researchers used many compounds, for example, 2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1COA of Formula: C4H7ClO2).

2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.COA of Formula: C4H7ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and properties of O-glycosyl calix[4]arenes (calixsugars) was written by Dondoni, Alessandro;Marra, Alberto;Scherrmann, Marie-Christine;Casnati, Alessandro;Sansone, Francesco;Ungaro, Rocco. And the article was included in Chemistry – A European Journal in 1997.Recommanded Product: 14131-84-1 This article mentions the following:

Model O-glycosylation reactions at either rim of calix[4]arenes are described with the aim of providing access to a new family of carbohydrate-containing calixarene derivatives named calixsugars. One or two sugar moieties (D-mannofuranose and D-glucopyranose) were introduced at the lower rim of the parent calix[4]arene by glycosylation of the phenolic hydroxyl groups by means of a Mitsunobu reaction. Tetrapropoxy calix[4]-arenes bearing two or four hydroxymethyl groups at the upper rim were coupled with perbenzoylated thioethyl D-galactoside and D-lactoside in the presence of the thiophilic promoter copper(II) triflate. In this way β-linked bis- and tetrakis-O-galactosyl calix[4]arenes were obtained in good yield, the latter showing some solubility in water. For the O-lactosyl derivatives only the bis-substituted compound could be obtained because of the competing formation of an intramol. ether linkage between 1,3-hydroxymethyl groups. Preliminary binding studies showed some affinity of the galactose-containing calixsugars toward charged carbohydrates and dihydrogen phosphate anion. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Recommanded Product: 14131-84-1).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 14131-84-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Application of growth promoting hormones alters the composition and antioxidant potential of dill essential oil under salt stress was written by Ghassemi-Golezani, Kazem;Nikpour-Rashidabad, Neda;Samea-Andabjadid, Samira. And the article was included in Scientific Reports in 2022.SDS of cas: 607-91-0 This article mentions the following:

The performance of dill plant may be affected by adverse environments such as salinity. Thus, this research was designed to evaluate changes in chem. composition and antioxidant activity of seed essential oil of dill (Anethum graveolens L.) in response to salinity (0, 5, 10 and 15 dS/m) and 1 mM of each hormonal treatments (gibberellic acid, salicylic acid, and cytokinin). Salicylic acid (SA) reduced Na+ content of roots and leaves by 15.4%, 30.9% and 12.4%, 24.3%, but enhanced K+ content by 29.8%, 51.6% and 76.6%, 73.4% under moderate and severe salinities, resp. Essential oil yield was enhanced with progressing seed filling, despite decreasing essential oil percentage. Percentage of essential oil was increased under low and moderate salinities. Hormonal treatments, particularly SA enhanced seed mass and essential oil percentage, leading to enhanced essential oil yield. The amounts of most constituents were enhanced under moderate salinity. Foliar spray of SA and CK (cytokinin) increased almost all essential oil components, except dill ether and dill apiole, while the GA3 (gibberellic acid) treatment reduced most of the constituents. The α-fenchol was only induced by salt stress. The β-pinene, 1-terpineol, cryptone, oxypeucedanin hydrate, α-thujene and P-α-dimethylstyrene were also specifically synthesized in SA treated plants under salinity. The highest TPC (total phenolic content) and antioxidant activity were recorded for essential oil of SA treated plants at mass maturity under moderate salinity. In general, the SA spray was the most effective treatment for improving essential oil quantity and quality of dill plants. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0SDS of cas: 607-91-0).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 607-91-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of butanone glycol ketal with strong acid cation-exchange resin was written by Liu, Chun-ling;Liu, He-qun;Gao, Wen-xiu. And the article was included in Huaxue Gongchengshi in 2007.Electric Literature of C6H12O2 This article mentions the following:

Butanone glycol ketal (i.e., 2-ethyl-2-methyl-1,3-dioxolane) was prepared by a reaction of butanone with glycol in the presence of a strongly acidic cation-exchange resin. The cation exchange resin’s catalytic activity to the ketal reaction was discussed. The factors influencing the product yield, such as molar ratio of ketone and alc., catalyst quantity and reaction time were systematically studied. The experiments showed that such a strong-acid cation-exchange resin is a good catalyst to synthesis of butanone glycol ketal. The yield of butanone glycol ketal reach 76.5% under the following optimum conditions: n(butanone) : (glycol) = 1:2, catalyst quantity is equal to 0.5% by mass of the total reaction materials, cyclohexane is used as water entrainment agent, the reaction time is 3h. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Electric Literature of C6H12O2).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Electric Literature of C6H12O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and Unexpected Transformation of 5-[(1,3-Dioxolan-2-ylmethyl)sulfanyl]-1H-pyrrol-2-amine into 5-{[2-(2-Hydroxyethoxy)ethenyl]sulfanyl}-1H-pyrrol-2-amine in the Presence of a Superbase was written by Nedolya, N. A.;Tarasova, O. A.;Albanov, A. I.;Trofimov, B. A.. And the article was included in Russian Journal of Organic Chemistry in 2021.Category: dioxole This article mentions the following:

Successive one-pot reactions of monolithiated N,N-diethylprop-2-yn-1-amine with 2-(ethenyloxy)ethyl isothiocyanate and 2-(bromomethyl)-1,3-dioxolane afforded I in 91% yield. In the system t-BuOK-DMSO at room temperature (1 h), the product was converted to E/Z-II (yield 68%) instead of expected 1-vinyl derivative In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Category: dioxole).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of a novel multi-SO₃H functionalized ionic liquid and its catalytic activities was written by Sun, Xudong;Xiao, Huiquan;Du, Yijun;Zhang, Jingjing;Liang, Xuezheng;Qi, Chenze. And the article was included in Kinetics and Catalysis in 2012.Computed Properties of C8H14O2 This article mentions the following:

A novel multi-SO₃H functionalized ionic liquid is synthesized and a detailed account of its catalytic activities in acetalization and acetylation is given. The results showed that the ionic liquid is very efficient in the conventional acid-catalyzed reactions with good to excellent yields within a short reaction time. Operational simplicity, small amounts required, low cost of the catalyst, high yields, scalability and reusability are the key features of this methodol., which indicates the high potentialities of the novel ionic liquid to be used in environmentally friendly processes. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Computed Properties of C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Investigation of the inhibition of leukotriene A₄ hydrolase was written by Ollmann, Ian R.;Hogg, J. Heather;Munoz, Benito;Haeggstroem, Jesper Z.;Samuelsson, Bengt;Wong, Chi-Huey. And the article was included in Bioorganic & Medicinal Chemistry in 1995.Synthetic Route of C6H11BrO2 This article mentions the following:

In an effort to better understand the favorable binding interactions between the reversible picomolar inhibitor 3-(4-benzyloxyphenyl)-2-(R)-amino-1-propanethiol (1) and leukotriene A₄ (LTA₄) hydrolase (EC 3.3.2.6), we prepared a number of derivatives of 1–L and other related structures, and assayed their inhibition of LTA₄ hydrolase-catalyzed hydrolysis of L-alanine-p-nitroanilide. The inhibition data was analyzed using a weighted non-linear least-squares curve fitting computer program developed for this purpose to fit data derived under the non-Michaelis-Menten condition of [T]_t < [E]_t. The free thiol is necessary for sub-micromolar binding and the enzyme prefers the R enantiomer over the S enantiomer, in contrast to the stereoselectivity displayed towards bestatin, an inhibitor of somewhat similar structure. Substitution of acid moieties around the periphery of the benzyloxyphenyl portion of 1–L leads to substantially decreased binding, suggesting that this group resides within a large hydrophobic pocket when bound to the enzyme. Possible LTA₄ binding modes in the active site of LTA₄ hydrolase, including a possible direct role for the carboxylic acid of LTA₄ in the enzyme-catalyzed hydrolysis of leukotriene A₄, are discussed. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Synthetic Route of C6H11BrO2).

2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Synthetic Route of C6H11BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem