Day: November 22, 2022

Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives was written by Gemma, Sandra;Kukreja, Gagan;Tripaldi, Pierangela;Altarelli, Maria;Bernetti, Matteo;Franceschini, Silvia;Savini, Luisa;Campiani, Giuseppe;Fattorusso, Caterina;Butini, Stefania. And the article was included in Tetrahedron Letters in 2008.Computed Properties of C11H8ClNO2 The following contents are mentioned in the article:

Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. This paper describes the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Computed Properties of C11H8ClNO2).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Computed Properties of C11H8ClNO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation of fructone from ethyl acetoacetate and ethylene glycol in the presence of copper benzenesulfonate as catalyst was written by Dong, Jing-hua. And the article was included in Huagong Jishu Yu Kaifa in 2013.Related Products of 6413-10-1 The following contents are mentioned in the article:

Fructone was prepared by condensation reaction of Et acetoacetate and ethylene glycol in the presence of copper benzene sulfonate. The influences of the reaction conditions on the yield of fructone were investigated. The optimum reaction conditions were as follows: molar ratio of Et acetoacetate/ethylene glycol, 1:1.5; catalyst dosage, 1.5wt% of reactants; water-carrying agent, cyclohexane; reaction time, 60min. Under the optimum reaction conditions, the yield of fructone was up to 82.7%. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Related Products of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of fructone by solid acid SO₄^2-/ZrO₂-TiO₂ was written by Liu, Xi-cheng. And the article was included in Guangzhou Huagong in 2011.SDS of cas: 6413-10-1 The following contents are mentioned in the article:

Fructone was synthesized with Et acetoacetate and glycol by using solid acid sulfate/zirconia-titania as catalyst. The effects of water-carrying reagent, feed ratio, reaction time, catalyst dosage on the yield of the product were studied. Results showed that the optimum reaction conditions were molar ratio of cyclohexanone to ethylene 1:1.5, catalyst dosage 2% of the total reactants, and the amount of cyclohexane 37.5% of the total reactants. After 2h reaction, the yield of fructone reached 76.8%. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1SDS of cas: 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of ketals of ethyl acetoacetate catalyzed by activated carbon supported SnCl₄·5H₂O under microwave irradiation was written by Zhang, Min;Yuan, Lin;Yuan, Xianyou. And the article was included in Guangzhou Huaxue in 2007.COA of Formula: C8H14O4 The following contents are mentioned in the article:

Two ketals were synthesized from Et acetoacetate with ethylene glycol and 1,2-propanediol using activated carbon supported SnCl₄·5H₂O (SnCl₄·5H₂O/C) as catalysts without solvent under microwave irradiation Under the optimum reaction conditions (SnCl₄·5H₂O/C (loaded amount 20%) 0.1 g), Et acetoacetate 5 mL, ethylene glycol 6 mL, microwave power 600 W, microwave irradiation time 2.5 mm, the yield of ketal was 81.6%. The products were characterized by IR. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1COA of Formula: C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.COA of Formula: C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Chemoenzymatic Synthesis of δ-Keto β-Hydroxy Esters as Useful Intermediates for Preparing Statins was written by Tartaggia, Stefano;Fogal, Stefano;Motterle, Riccardo;Ferrari, Clark;Pontini, Marta;Aureli, Roberto;De Lucchi, Ottorino. And the article was included in European Journal of Organic Chemistry in 2016.Category: dioxole The following contents are mentioned in the article:

Enantiopure (R)-3-hydroxy-5-oxohexanoic acid esters have proven to be useful intermediates in the synthesis of the side chain of statins, in view of the recently described preparation of rosuvastatin and other statins through aldol reactions. Herein, an improved synthesis of these intermediates, by combining chem. and enzymic reactions, is described. In particular, the selective reduction of a δ-ketal β-keto ester was identified as a key step to obtain derivatives with satisfactory optical purities for use in the synthesis of statins. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Category: dioxole).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A chemical probe for the methyl transferase PRMT5 with a novel binding mode was written by Pande, Vineet;Sun, Weimei;Beke, Lijs;Berthelot, Didier;Brehmer, Dirk;Brown, David;Corbera, Jordi;Irving, Steve;Meerpoel, Lieven;Nys, Thomas;Parade, Marc;Robinson, Colin;Sommen, Cois;Viellevoye, Marcel;Wu, Tongfei;Thuring, Jan Willem. And the article was included in ACS Medicinal Chemistry Letters in 2020.Related Products of 158078-04-7 The following contents are mentioned in the article:

Protein arginine methyltransferase 5 (PRMT5) is an enzyme that can sym. dimethylate arginine residues in histones and nonhistone proteins by using S-adenosyl methionine (SAM) as the Me donating cofactor. We have designed a library of SAM analogs and discovered potent, cell-active, and selective spiro diamines as inhibitors of the enzymic function of PRMT5. Crystallog. studies confirmed a very interesting binding mode, involving protein flexibility, where both the cofactor pocket and part of substrate binding site are occupied by these inhibitors. This study involved multiple reactions and reactants, such as ((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (cas: 158078-04-7Related Products of 158078-04-7).

((3aR,4R,6R,6aR)-6-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (cas: 158078-04-7) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 158078-04-7

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Odor maps in the olfactory cortex. [Retraction of document cited in CA143:004790] was written by Zou, Zhihua;Li, Fusheng;Buck, Linda B.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2010.Related Products of 6413-10-1 The following contents are mentioned in the article:

At the request of Fusheng Li and Linda B. Buck, this article is retracted. This article described patterns of c-Fos labeling in anterior piriform cortex following exposure of mice to odorants. In efforts to replicate this work, the authors observed c-Fos in sparsely distributed neurons, as reported, but found no evidence for the reported finding that odorants induce related patterns of c-Fos labeling in the two hemispheres and in different individuals. Inconsistencies have also been found between several images shown in the paper and the original data. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Related Products of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Related Products of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors was written by Brindisi, Margherita;Brogi, Simone;Giovani, Simone;Gemma, Sandra;Lamponi, Stefania;De Luca, Filomena;Novellino, Ettore;Campiani, Giuseppe;Docquier, Jean-Denis;Butini, Stefania. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2016.Computed Properties of C11H8ClNO2 The following contents are mentioned in the article:

Metallo-β-lactamases (MBLs) represent one of the most important and widespread mechanisms of resistance to β-lactam antibiotics (including the life-saving carbapenems), against which no clin. useful inhibitors are currently available. Here, the authors report a structure-based high-throughput docking campaign on 3 clin.-relevant acquired MBLs (IMP-1, NDM-1 and VIM-2). The initial hit, NF 1810, was optimized providing the broad-spectrum inhibitor , which was able to potentiate the in vitro activity of cefoxitin on a VIM-2-producing Escherichia coli strain. This study involved multiple reactions and reactants, such as 8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2Computed Properties of C11H8ClNO2).

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline (cas: 50593-65-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C11H8ClNO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Highly efficient and chemo selective catalyst system for synthesis of blossom orange fragrance and flavoring compounds was written by Justus, Josena;Vinu, Ajayan;Devassy, Biju M.;Balasubramanian, Veerappan V.;Bohringer, Walter;Fletcher, Jack;Halligudi, S. B.. And the article was included in Catalysis Communications in 2008.Category: dioxole The following contents are mentioned in the article:

Acetal and acylal formation reactions of organic compounds are efficiently catalyzed by zirconia-supported mixed oxide systems under liquid-phase reaction conditions. 15WZ-750 (where, W = WO₃ and Z = ZrO₂) was the most active catalyst, which could be recyclable without loss in its activities. This study reports the use of a non zeolitic solid acid catalyst systems based on zirconia-supported isopoly and heteropoly acids, which are highly efficient, chemoselective, eco-friendly and cost effective catalysts for use in the condensation reactions. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Category: dioxole).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

I₂-doped chitosan: an easily recoverable and efficient catalyst for acetalization of carbonyl compounds with diols was written by Liu, Chun-Sheng;Luo, Gen-Xiang. And the article was included in Polymer-Plastics Technology and Engineering in 2009.Category: dioxole The following contents are mentioned in the article:

Chitosan-I₂ is prepared by doping of chitosan with iodine (I₂). Chitosan-I₂ are characterized by phys. and spectral methods. Chitosan-I₂ is used as catalyst for the first time in acetalization of carbonyl compounds The catalyzed acetalization of benzaldehyde and glycol is conducted in excellent yields with simple and more environmental benign procedure. The use of chitosan-I₂ catalyst is feasible because of its easy preparation, easy handling, stability, easy recovery, reusability, good activity and eco-friendly. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Category: dioxole).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem