Day: November 21, 2022

Wang, Rui published the artcileCrystal structure, thermal decomposition mechanism and catalytic performance of hexaaquaaluminum methanesulfonate, Recommanded Product: 1,4-Dioxaspiro[4.5]decane, the publication is Journal of Coordination Chemistry (2017), 70(8), 1327-1338, database is CAplus.

Hexaaquaaluminum methanesulfonate crystals, [Al(H₂O)₆][CH₃SO₃]₃ (1) were synthesized by a hydrothermal reaction of Al(OH)₃ with methanesulfonic acid. Single-crystal diffraction determination revealed that Al³⁺ was coordinated by six water mols. in octahedral geometry, while the CH₃SO₃^– anion connected with Al³⁺ through coordinated water mols. by hydrogen bonds. The six-coordinate environment of Al was also determined by ²⁷Al MAS NMR measurement. TGA and FTIR spectroscopy showed that the decomposition intermediate at 265-365° was Al₂(μ-OH)(CH₃SO₃)₅ (2) and the final product was amorphous Al₂O₃ residue with ∼0.8% SO₃ at 520-800°. A pure phase of [Al(H₂O)₆][CH₃SO₃]₃ was confirmed by powder x-ray diffraction anal. Esterification of n-butyric acid with n-butanol and ketalization of cyclohexanone with glycol catalyzed by [Al(H₂O)₆][CH₃SO₃]₃ and Al₂(μ-OH)(CH₃SO₃)₅, resp., proceeded in 100% yield by continuously removing the produced water. In the case of tetrahydropyranylation of n-butanol at room temperature in dichloromethane, the catalytic activity of [Al(H₂O)₆][CH₃SO₃]₃ was much lower than that of Al₂(μ-OH)(CH₃SO₃)₅. Furthermore, both [Al(H₂O)₆][CH₃SO₃]₃ precursor and Al₂(μ-OH)(CH₃SO₃)₅ catalysts could be recycled.

Journal of Coordination Chemistry published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H6BF3O3, Recommanded Product: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

He, Cheng-Yu published the artcileCopper-Catalyzed Asymmetric Borylative Cyclization of Cyclohexadienone-Containing 1,6-Dienes, HPLC of Formula: 503538-69-0, the publication is Advanced Synthesis & Catalysis (2020), 362(4), 765-770, database is CAplus.

Due to the low reactivity of 1,6-dienes and the challenge of selectively differentiating such two olefins, the development of metal-catalyzed asym. cyclization of 1,6-dienes remains largely underdeveloped. Herein, the authors describe the 1st Cu(I)-catalyzed asym. borylative cyclization of cyclohexadienone-tethered terminal alkenes (1,6-dienes) via a tandem process: the regioselective borocupration of the electron-rich terminal alkene and subsequent conjugate addition of stereospecific secondary alkyl-Cu(I) to the electron-deficient cyclohexadienone, affording enantioenriched bicyclic skeletons bearing three contiguous stereocenters in all cis-form. Meanwhile, this mild catalytic protocol is generally compatible with a wide range of functional groups, which allows further facile conversion of the cyclization products.

Advanced Synthesis & Catalysis published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, HPLC of Formula: 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Tan, Yu Jia published the artcileAmide-Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility, Related Products of dioxole, the publication is ACS Medicinal Chemistry Letters (2021), 12(5), 704-712, database is CAplus and MEDLINE.

Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here, it was found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility Potent activity could be achieved without the carboxamide linker but not in the absence of the indole ring. The indolylmethylamine, N-cyclooctyl-6-trifluoromethylindol-2-ylmethylamine (MIC_90Mtb 0.13μM, MBC_99.9Mtb 0.63μM), exemplifies a promising member that is more soluble and equipotent to its carboxamide equivalent It is also an inhibitor of the mycolate transporter MmpL3, a property shared by the methylamines of benzothiophene and benzoselenophene.

ACS Medicinal Chemistry Letters published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C18H17NO8, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Liu, Bin-bin published the artcileOdorless thioacetalization reaction of acetals, Computed Properties of 177-10-6, the publication is Liaoning Huagong (2014), 43(9), 1112-1113, database is CAplus.

Using 2-(1,3-dithian-2-ylidene)-3-oxobutanoic acid as odorless thiol equivalent, an efficient and odorless transthioacetalization of acetals has been developed in the presence of MeCOCl in MeOH at room temperature This transthioacetalization is characterized by mild reaction conditions, simple procedure and good yield. It is noteworthy that odor of thiols can not be perceived during the reaction.

Liaoning Huagong published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Computed Properties of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Tan, Xin published the artcileThree-Dimensional Phosphine Metal-Organic Frameworks Assembled from Cu(I) and Pyridyl Diphosphine, COA of Formula: C8H14O2, the publication is Chemistry of Materials (2012), 24(3), 480-485, database is CAplus.

Metal-organic frameworks (MOFs) with phosphine based ligands are extremely attractive for catalysis. Phosphine was successfully incorporated for the first time into three-dimensional (3D) MOFs. The MOFs are based on rigid L₂M₂ dimeric secondary building blocks assembled from Cu(I) and a pyridyl diphosphine ligand, 4-(3,5-bis(diphenylphosphino)phenyl)pyridine, with Br^– (CuL-Br), Cl^– (CuL-Br), or PF₆^– (CuL-PF₆) as counteranions [L = 4-(3,5-bis(diphenylphosphino)phenyl)pyridine]. The structures have a 4.12² net topol., which can be further simplified to 6⁴.8²-qtz. The MOFs contain 1D homochiral channels. The PF₆^– anions hosted in the 1D channel of CuL-PF₆ can be readily exchanged with Br^– or Cl^– while keeping the framework intact. The materials show anion-tunable flexible porosity. CuL-Br reveals gradual uptake of MeOH, while CuL-PF₆ exhibits stepwise sorption for MeOH. The heterogeneous Lewis acid catalytic activity of the MOFs was shown in ketalization reaction. CuL-Br and CuL-PF₆ are active in the reactions between ethylene glycol and 2-butanone/cyclohexanone, up to 93% yield with 0.2 mol % catalyst loading. In contrast, no reaction happens between ethylene glycol and bulky benzophenone, suggesting profound size selectivity. The catalysts can be reused with the framework left intact for three runs without loss of activity.

Chemistry of Materials published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C16H20N2, COA of Formula: C8H14O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Hurley, Scott published the artcileEffects of impregnated metal ions on air/CO₂-gasification of woody biomass, Safety of 2,2,4-Trimethyl-1,3-dioxolane, the publication is Bioresource Technology (2010), 101(23), 9301-9307, database is CAplus and MEDLINE.

Several impregnated metal ions (Fe (III), Co (II), Ni (II), and Ru (IV)) and a raw iron ore (natural limonite) were examined as catalysts for gasification of pine sawdust in air/CO₂ at 700 and 800°. The yields of char and tar both increased with increasing CO₂ content in the feed gas. All the impregnated metal ions, in particular Ni (II), Co (II) and Ru (IV), were very effective for promoting biomass gasification in CO₂, leading to greatly reduced yields of tar and char accompanied by significantly enhanced formation of CO and H₂. At 800°, the impregnation of Fe (III), Ni (II), Co (II) or Ru (IV) led to almost complete conversion of the solid biomass into gas/liquid products, producing an extremely low char yield ( < 1-4%), and a very high yield of combustible gas (from 51.7% for Fe to 84% for Ru). The tar yield reduced from 32.1% without catalyst to 19-27% with the impregnated metal ions.

Bioresource Technology published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Safety of 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Bonner, Trevor G. published the artcileOpening of cyclic acetals by trichloro-, dichloro-, and tribromoborane, HPLC of Formula: 1193-11-9, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1981), 1807-10, database is CAplus.

Reaction of cyclic acetals with BCl₃ gave α-chloro ethers which on in situ LiAlH₄ reduction gave hydroxy ethers in 49-99% yield. E.g., treatment of 2-propyl-1,3-dioxolane with BCl₃ (CH₂Cl₂, ∼0°, 0.2 h) followed by LiAlH₄ (Et₂O, 30 min) gave >95% HO(CH₂)₂OBu. The rate determining step in this reaction is the formation of an intermediate oxocarbenium ion. BBr₃ was a more, and BHCl₂ a less, powerful reagent than BCl₃ for this reaction.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, HPLC of Formula: 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Jung, Jong-Min published the artcileControl of the fate of toxic pollutants from catalytic pyrolysis of polyurethane by oxidation using CO₂, COA of Formula: C6H12O2, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 442(Part_1), 136358, database is CAplus.

In automotive industry, plastic consumption has substantially increased due to its affordability, durability, and lightness. However, the massive generation of plastic wastes from the automotive industry becomes a growing environmental concern. Current disposal methods of end-of-life vehicles (ELVs) are incineration and landfilling, but these methods generate toxic chems. and leachate into the environment. To propose more sustainable disposal platform for ELVs, this study used a pyrolysis process using CO₂ as a reaction medium. As a case study, automotive seat form (ASF) in ELVs was disposed and valorized through the CO₂-assisted pyrolysis. ASF, composed of polyurethane, generated harmful aromatic compounds during pyrolysis process such as benzene, aniline and their derivatives To convert harmful chems. into value-added syngas (H₂ and CO), catalytic pyrolysis of ASF was performed using a nickel catalyst. Effects of both CO₂ and nickel catalyst showed 89.9 wt% reduction of toxic chem. production by converting them into syngas, as comparing to pyrolysis without Ni catalyst. Gas-phase-reaction between CO₂ and pyrogenic products from ASF resulted in more than 200 times of CO production Also, CO₂ suppressed catalyst deactivation. Therefore, this study suggested that CO₂ and plastic waste from ELVs can be converted to value-added products through CO₂-assisted catalytic pyrolysis.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, COA of Formula: C6H12O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Kim, Sung Phil published the artcileElm tree (Ulmus parvifolia) bark bioprocessed with mycelia of shiitake (Lentinus edodes) mushrooms in liquid culture: Composition and mechanism of protection against allergic asthma in mice, Recommanded Product: 1,4-Dioxaspiro[4.5]decane, the publication is Journal of Agricultural and Food Chemistry (2016), 64(4), 773-784, database is CAplus and MEDLINE.

Mushrooms can break down complex plant materials into smaller, more digestible and bioactive compounds The present study investigated the antiasthma effect of an Ulmus parvifolia bark extract bioprocessed in Lentinus edodes liquid mycelium culture (BPUBE) against allergic asthma in chicken egg ovalbumin (OVA)-sensitized/challenged mice. BPUBE suppressed total IgE release from U266B1 cells in a dose-dependent manner without cytotoxicity. Inhibitory activity of BPUBE against OVA-specific IgE secretion in bronchoalveolar lavage fluid (BALF) was observed in OVA-sensitized/challenged asthmatic mice. BPUBE also inhibited OVA-specific IgG and IgG1 secretion into serum from the allergic mice, suggesting the restoration of a Th2-biased immune reaction to a Th1/Th2-balanced status, as indicated by the Th1/Th2 as well as regulatory T cell (Treg) cytokine profile changes caused by BPUBE in serum or BALF. Inflammatory cell counts in BALF and lung histol. showed that leukocytosis and eosinophilia induced by OVA-sensitization/challenge were inhibited by the oral administration of BPUBE. Amelioration of eosinophil infiltration near the trachea was associated with reduced eotaxin and vascular cell adhesion mol.-1 (VCAM-1) levels. Changes in proinflammatory mediator levels in BALF suggest that BPUBE decreased OVA-sensitization-induced elevation of leukotriene C₄ (LTC₄) and prostaglandin D₂ (PGD₂). The finding that asthma-associated biomarker levels of OVA-sensitized/challenged mice were much more inhibited with BPUBE treatment than NPUBE (not-bioprocessed Ulmus parvifolia extract) treatment suggested the production of new bioactive compounds by the mushroom mycelia that may be involved in enhancing the observed antiasthmatic properties. The possible relation of the composition determined by proximate anal. and GC/MS to observed bioactivity is discussed. The results suggest that the elm tree (Ulmus parvifolia) bark bioprocessed with mycelia of shiitake (Lentinus edodes) mushrooms has the potential to prevent and/or treat allergic asthma.

Journal of Agricultural and Food Chemistry published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Recommanded Product: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Tolstoy, Paivi published the artcileSynthesis of Enantiomerically Enriched 3-Amino-2-oxindoles through a Palladium-Mediated Asymmetric Intramolecular Arylation of α-Ketimino Amides, HPLC of Formula: 503538-69-0, the publication is Organic Letters (2012), 14(18), 4810-4813, database is CAplus and MEDLINE.

A highly efficient and enantioselective synthesis of 3-amino-2-oxindoles through a palladium-catalyzed asym. intramol. arylation of α-ketimino amides using (R)-DiFluorPhos as the coordinating ligand is reported. This report constitutes the first enantioselective palladium-catalyzed arylation of ketimines.

Organic Letters published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C15H21BO4, HPLC of Formula: 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem