Day: November 21, 2022

Abdallah, Samira A. published the artcileToxicological and phytochemical studies of wild plant Halocnemon strobilacium crude extracts and their components against Aphis craccivora Koch, SDS of cas: 1193-11-9, the publication is Journal of Applied Sciences Research (2009), 5(7), 699-705, database is CAplus.

Toxicol. and phytochem. studies were conducted on the Halocnemon strobilacium. Results indicated that the Et acetate crude extract with LC₅₀ value 0.159 mg/cm² and LC₉₅ value 1.845 mg/cm² was the most effective against Aphis craccivora comparing with fraction B (LC₅₀ 1.522 mg/cm² and LC₉₅ 4.721 mg/cm²) as well as fraction A (LC₅₀ 1.299 mg/cm² and LC₉₅ 3.899 mg/cm²). Data also showed that, the crude extract was composed mainly of saturated and unsaturated fatty acids and their esters (69.34%) followed by hydrocarbons (9.89%). Only two terpenes were identified in this crude extract, one of them was Phytol isomer, a diterpene detected with 2.26%. Oleic acid ester (38.18 %) and Octadecanoic acid (16.44%) were the major constituents. The main compounds in Fraction A were hydrocarbons, fatty acids and their esters. Lumiflavine represented about 35.66. Five fatty acids and esters were identified and constituted 39% with Oleic acid ester (14.74%) Octadecanoic acid Me ester (4.41%) and Tetradecanoic acid (3.88%) being the major representatives. In fraction B twenty three compounds were identified. Unoxygenated compounds amount to 9.89, the main hydrocarbons being di-Me undecane (5.20%) and trimethyldecane (1.01%). Oxygenated compounds constitute 90.11% of the fraction comprising fatty acids and esters, ketones as well as aldehydes (46.08%, 17.94% and 3.29% of the fraction resp.). The main ester identified was octadecanoic acid, Me ester (3.44%) while hexadecanoic acid was the main fatty acid detected (22.69%).

Journal of Applied Sciences Research published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, SDS of cas: 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Yadav, Ram Naresh published the artcileA Versatile Method for the Protection of Carbonyl Compounds by Camphor Sulfonic Acid, Formula: C8H14O2, the publication is Current Organocatalysis (2018), 5(3), 196-200, database is CAplus and MEDLINE.

In this paper, camphor sulfonic acid-catalyzed protection of various carbonyl compounds is developed. This method is simple, environmentally friendly and yields products in high yields under mild reaction conditions. Camphor sulfonic acid is used as organocatalyst for the protection of carbonyl functionality. This catalyst is also employed for the protection of carbonyl functionality as thioacetal/mixed ketal in excellent yield.

Current Organocatalysis published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C5H8N2O2, Formula: C8H14O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Hassner, Alfred published the artcileA mild, room-temperature protection of ketones and aldehydes as 1,3-dioxolanes under basic conditions, COA of Formula: C8H14O2, the publication is Synlett (2012), 23(19), 2773-2776, database is CAplus.

Protection of ketones or aldehydes as 1,3-dioxolane derivatives proceeds within minutes at room temperature in the presence of N-hydroxybenzenesulfonamide, its O-benzyl derivative, or the tosyl analog, in the absence of strong protonic acids, and in the presence of base (Et₃N). Acid-sensitive groups such as O-THP, O-TBS, or N-Boc are unaffected.

Synlett published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, COA of Formula: C8H14O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Sun, Xin published the artcileIridium-Catalyzed Asymmetric Hydroalkenylation of Norbornene Derivatives, SDS of cas: 503538-69-0, the publication is Organometallics (2021), 40(14), 2182-2187, database is CAplus.

Transition-metal-catalyzed asym. hydroalkenylation of alkenes provides an atom-economical method to build mol. complexity from easily available materials. Herein we report an iridium-catalyzed asym. hydroalkenylation of unconjugated alkenes with acrylamides and acrylates. The catalytic hydroalkenylation of norbornene derivatives occurred to form products with allylic stereocenters with high chemo-, regio-, and stereoselectivities. DFT calculations revealed that the migratory insertion is irreversible and the enantiodetn. step.

Organometallics published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C18H26ClN3O, SDS of cas: 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Bygd, Madison D. published the artcileUnexpected mechanism of biodegradation and defluorination of 2,2-difluoro-1,3-benzodioxole by Pseudomonas putida F1, Computed Properties of 503538-69-0, the publication is mBio (2021), 12(6), e03001, database is CAplus and MEDLINE.

Perfluorinated carbon atoms in a diether linkage are common in com. anesthetics, drugs, fungicides, and insecticides. An important chem. group comprising perfluorodiethers is the 2,2-fluoro-1,3-benzodioxole (DFBD) moiety. The fluorine atoms stabilize the mol. by mitigating against metabolism by humans and microbes, as used in drugs and pesticides, resp. Pseudomonas putida F1 catalyzed defluorination of DFBD at an initial rate of 2,100 nmol/h per mg cellular protein. This is orders of magnitude higher than previously reported microbial defluorination rates with multiply fluorinated carbon atoms. Defluorination rates declined after several hours, and the medium darkened. Significant defluorination activity was observed with cells grown on toluene but not l-arginine. Defluorination required only toluene dioxygenase. Pseudomonas and recombinant Escherichia coli cells expressing toluene dioxygenase oxidized DFBD to DFBD-4,5-dihydrodiol. The dihydrodiol could be oxidized to 4,5-dihydroxy-DFBD via the dihydrodiol dehydrogenase from P. putida F1. The dihydrodiol dehydrated with acid to yield a mixture of 4-hydroxy-DFBD and 5-hydroxy-DFBD. All those metabolites retained the difluoromethylene group; no fluoride or dark color was observed The major route of DFBD-4,5-dihydrodiol decomposition produced fluoride and 1,2,3-trihydroxybenzene, or pyrogallol, and that was shown to be the source of the dark colors in the medium. A mechanism for DFBD-4,5-dihydrodiol transformation to two fluoride ions and pyrogallol is proposed. The Pseudomonas genome database and other databases revealed hundreds of bacteria with enzymes sharing high amino acid sequence identity to toluene dioxygenase from P. putida F1, suggesting the mechanism revealed here may apply to the defluorination of DFBD-containing compounds in the environment.

mBio published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Computed Properties of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Potowski, Marco published the artcileCatalytic asymmetric exo-selective [6+3] cycloaddition of iminoesters with fulvenes, COA of Formula: C38H24F4O4P2, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(71), 7800-7802, database is CAplus and MEDLINE.

A novel exo-selective [6+3] cycloaddition approach for the highly enantioselective synthesis of polysubstituted piperidines was developed. The developed methodol. was applied in a one-pot [6+3]-[4+2] dicycloaddn., allowing the construction of structurally and stereochem. rich polycyclic compounds from simple building blocks.

Chemical Communications (Cambridge, United Kingdom) published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, COA of Formula: C38H24F4O4P2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Hargrave, Jonathan D. published the artcileCatalytic Enantioselective Dieckmann-Type Annulation: Synthesis of Pyrrolidines with Quaternary Stereogenic Centers, Application of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, the publication is Angewandte Chemie, International Edition (2010), 49(10), 1825-1829, S1825/1-S1825/70, database is CAplus and MEDLINE.

A Dieckmann-type cyclization coupled to an arylation reaction was used to synthesize the title compounds, e.g., I, with up to 96% ee from amine-tethered ester-substituted acrylates. The presence of a coordinating functionality in the substrate, e.g., II, induces a competition between cyclization and elimination pathways that is influenced by the nature of the chiral ligand. A mechanistic rationale is proposed to account for these observations.

Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Application of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Langlois, Jean-Baptiste published the artcileCopper-catalyzed asymmetric allylic alkylation of racemic cyclic substrates: Application of dynamic kinetic asymmetric transformation (DYKAT), Quality Control of 503538-69-0, the publication is Advanced Synthesis & Catalysis (2010), 352(2+3), 447-457, database is CAplus.

The copper-catalyzed asym. allylic alkylation (AAA) is of great interest in organic synthesis. This reaction was extensively studied using a broad range of substrates, ligands and organometallic reagents. However, the use of racemic substrates was still limited. Although some processes of kinetic resolution are reported in the literature, no examples of quant. deracemization are described as is the case for the Pd-catalyzed allylic alkylation. The development and results of the copper-catalyzed AAA is reported. High enantioselectivities, scope of the reaction and mechanistic considerations are reported herein.

Advanced Synthesis & Catalysis published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Quality Control of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Anteunis, M. published the artcileNuclear magnetic resonance experiments on ketals. III. Proton magnetic resonance (P.M.R.) spectrum and conformations of the glycol ketal of 1,2-propanediol with acetone and acetaldehyde, Safety of 2,2,4-Trimethyl-1,3-dioxolane, the publication is Bulletin des Societes Chimiques Belges (1964), 73(11-12), 889-97, database is CAplus.

cf. CA 61, 10570h. The H N.M.R. (P.M.R.) spectra of 2,2,4-trimethyl-1,3-dioxolane (I) and cis- and trans-2,4-dimethyl-1,3-dioxolane (II) were determined and analyzed. The chem. shifts are in accordance with a half-chair conformation. The 1,3-H-Me interaction causes an upfield shift of ∼0.15 ppm. when the 2 are cis to one another. A similar shift of 0.05 ppm. was noted for a cis-1,3-Me-Me interaction. In I and cis-II, long-range coupling between the 4-Me and the methylene H cis to it is observed. I (b. 100°) was prepared from Me₂C(OMe)₂ (0.3 moles), propanediol (III) (0.2 moles), and H₂SO₄ catalyst. II was prepared by slow distillation of MeCH0 from acidified paraldehyde into III. Separation of the product by gas-liquid chromatography gave cis-II, b. 91.8°, n²⁵ 1.3945, d_23.6 0.92786, m. 55-60°; and trans-II, b. 89.5°, n²⁵ 1.3928; d_23.0 0.91570. meso4,5-Dimethyl-1,3-dioxolane (b. 104°) was prepared by azeotropic H₂O removal with C₆H₆ from a mixture of monobutanediol and (HCHO)_x. The HCHO ketal of 4,5-trimethylene-1,3-dioxolane prepared similarly b. 80°/18 mm.

Bulletin des Societes Chimiques Belges published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Safety of 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Alikarami, Mohammad published the artcileOxidative deprotection of trimethylsilyl and tetrahydropyranyl ethers, acetals and ketals with N,N’-dibenzyl-1,4-diazoniabicyclo[2.2.2]octane peroxodisulfate under non-aqueous conditions, Name: 1,4-Dioxaspiro[4.5]decane, the publication is Organic Chemistry: An Indian Journal (2013), 9(11), 463-468, database is CAplus.

An efficient and convenient conversion of trimethylsilyl and tetrahydropyranyl ethers, acetals and ketals to the corresponding carbonyl compounds with N,N’-dibenzyl-1,4-diazoniabicyclo[2.2.2]octane peroxodisulfate under non-aqueous conditions is described.

Organic Chemistry: An Indian Journal published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Name: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem