Day: November 21, 2022

Yang, Fan published the artcilePalladium/Lewis Acid Co-catalyzed Divergent Asymmetric Ring-Opening Reactions of Azabenzonorbornadienes with Alcohols, Name: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, the publication is Organic Letters (2016), 18(19), 4832-4835, database is CAplus and MEDLINE.

By fine tuning the combinations of chiral palladium catalysts and Lewis acids, both the addnl. and reductive asym. ring-opening reactions of azabenzonorbornadienes with alcs. were accomplished with good chemoselectivity, regioselectivity, and enantioselectivity. It was proven that the reductive ring-opening products were generated through a transfer hydrogenation process with alcs. as hydrogen source.

Organic Letters published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C4H5BN2O2, Name: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Sun, Huan-Li published the artcileAsymmetric Hydrogenation of α-Purine Nucleobase-Substituted Acrylates with Rhodium Diphosphine Complexes: Access to Tenofovir Analogues, Related Products of dioxole, the publication is Organic Letters (2016), 18(9), 2260-2263, database is CAplus and MEDLINE.

The first asym. hydrogenation of α-purine nucleobase-substituted α,β-unsaturated esters, catalyzed by a chiral rhodium (R)-Synphos catalyst, has been developed. A wide range of mono- and disubstituted acrylates were successfully hydrogenated under very mild conditions in high yields with good to excellent enantioselectivities (up to 99% ee). This method provides a convenient approach to the synthesis of a new kind of optically pure acyclic nucleoside and Tenofovir analogs.

Organic Letters published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C11H21BO2Si, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Abouassali, Obada published the artcileIn vitro and in vivo cardiac toxicity of flavored electronic nicotine delivery systems, Recommanded Product: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, the publication is American Journal of Physiology (2021), 320(1), H133-H143, database is CAplus and MEDLINE.

The usage of flavored electronic nicotine delivery systems (ENDS) is popular, specifically in the teen and young adult age-groups. The possible cardiac toxicity of the flavoring aspect of ENDS is largely unknown. Vaping, a form of electronic nicotine delivery, uses “e-liquid” to generate “e-vapor,” an aerosolized mixture of nicotine and/or flavors. We report our investigation into the cardiotoxic effects of flavored e-liquids E-vapors containing flavoring aldehydes such as vanillin and cinnamaldehyde, as indicated by mass spectrometry, were more toxic in HL-1 cardiomyocytes than fruit-flavored e-vapor. Exposure of human induced pluripotent stem cell-derived cardiomyocytes to cinnamaldehyde or vanillin-flavored e-vapor affected the beating frequency and prolonged the field potential duration of these cells more than fruit-flavored e-vapor. In addition, vanillin aldehyde-flavored e-vapor reduced the human ether-a-go-go-related gene (hERG)-encoded potassium current in transfected human embryonic kidney cells. In mice, inhalation exposure to vanillin aldehyde-flavored e-vapor for 10 wk caused increased sympathetic predominance in heart rate variability measurements. In vivo inducible ventricular tachycardia was significantly longer, and in optical mapping, the magnitude of ventricular action potential duration alternans was significantly larger in the vanillin aldehyde-flavored e-vapor-exposed mice than in controls. We conclude that the widely popular flavored ENDS are not harm free, and they have a potential for cardiac harm. More studies are needed to further assess their cardiac safety profile and long-term health effects.

American Journal of Physiology published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, Recommanded Product: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Majumdar, Swapan published the artcileActivation Of 1,3-Dioxolane By A Protic Ionic Liquid In Aqueous Media: A Green Strategy For The Selective Hydrolytic Cleavage Of Acetals and Ketals, Safety of 1,4-Dioxaspiro[4.5]decane, the publication is RSC Advances (2014), 4(32), 16497-16502, database is CAplus.

A convenient method for the deprotection of acetals and ketals was achieved using an imidazolium based protic ionic liquid as a catalyst in aqueous medium via the dual activation of dioxolane. The protocol is highly efficient towards the deprotection of acyclic and cyclic acetals, ketals, benzylidene acetals and tetrahydropyranyl (THP) ethers, giving excellent yields. Functional groups such as tert-Bu ester, tert-Bu di-Me silyl (TBDMS), N-tert-butyloxycarbonyl (N-Boc), and double bond, mesyl, nitro, and glycosidic linkage were tolerated under the benign reaction conditions. Selective deprotection of the 5,6-isopropylidene moiety in 1,2:5,6-di-O-isopropylidene hexose and 3,5-cyclohexylidene moiety in pentose derivatives proceeded smoothly without affecting the 1,2-protected group. The attractive features of this new protocol are the use of mild reaction conditions, tolerance of a wide range of functional groups, use of relatively non-toxic solvent systems and recyclability of the ionic liquid catalyst.

RSC Advances published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Safety of 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Seiser, Tobias published the artcileEnantioselective construction of indanones from cyclobutanols using a rhodium-catalyzed C-C/C-H/C-C bond activation process, Safety of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, the publication is Synlett (2010), 1699-1703, database is CAplus.

Enantioselective rhodium(I)-catalyzed reactions of tert-cyclobutanols, e.g. I, lead to indanones with quaternary stereogenic centers, e.g. II, via consecutive C-C/C-H/C-C bond activations.

Synlett published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C23H43NP2, Safety of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Azzena, Ugo published the artcileCyclopentyl methyl ether-NH₄X: a novel solvent/catalyst system for low impact acetalization reactions, Computed Properties of 177-10-6, the publication is Green Chemistry (2015), 17(6), 3281-3284, database is CAplus.

Cyclopentyl Me ether, a low impact ether forming a pos. azeotrope with water, was successfully employed as a solvent in the synthesis of 1,3-dioxanes and 1,3-dioxolanes carried out under Dean-Stark conditions by the acetalization of aliphatic and aromatic aldehydes or ketones, employing ammonium salts as environmentally friendly acidic catalysts.

Green Chemistry published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Computed Properties of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Du, Jing published the artcileSynthesis and catalytic activities of two new extended Preyssler-type tungstophosphates with different cavity centers, Synthetic Route of 177-10-6, the publication is Inorganic Chemistry Communications (2016), 119-123, database is CAplus.

Two new extended Preyssler-type polyoxometalates (POMs) constructed by Fe(III), 2,2′-biimidazole and Preyssler-type tungstophosphate anions with Na and Ag cavity centers, resp., {(H₄biim)₅H[Fe(H₂biim)(H₂O)₂(ZP₅W₃₀O₁₁₀)]·17H₂O}_n (Z = Na, 1; Z = Ag, 2; H₂biim = 2,2′-biimidazole), were designed and synthesized under hydrothermal conditions, and were systematically characterized by physicochem. and spectroscopic methods. The two compounds are isostructural coordination polymers. In compound 1 or 2, there exists interesting infinite 1-dimensional chains composed of Preyssler-type [ZP₅W₃₀O₁₁₀]^14- (abbreviated as {ZP₅W₃₀}) polyanions bridged by Fe(III)-complex fragments, and these chains further formed 3-dimensional supramol. frameworks via extensive H-bonding interactions. For 2, two types of transition metals, i.e. one Ag⁺ ion as a center in the inner cavity and two Fe³⁺ ions as modified cations on the outer surface of one {ZP₅W₃₀} unit, exist in the same compound Also, the electrochem. behaviors and acid catalytic activities of 1 and 2 were studied.

Inorganic Chemistry Communications published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Synthetic Route of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Li, Li published the artcileMetal-containing TUD-1 mesoporous silicates as versatile solid acid catalysts for the conversion of bio-based compounds into valuable chemicals, Quality Control of 68527-74-2, the publication is Inorganica Chimica Acta (2015), 289-296, database is CAplus.

Three-dimensional mesoporous silicates of the TUD-1 family were synthesized with different metals (Zr, Hf and Sn) incorporated in the framework of the material. The mesoporosity of the prepared TUD-1s was confirmed by x-ray diffraction (x-ray diffraction), nitrogen physisorption and TEM. The incorporation of the metals in the silicate structure was investigated by FT-IR and UV-Vis spectroscopy. All three TUD-1 materials present a combination of Lewis and mild Bronsted acid sites, as determined by TPD-FT-IR of pyridine adsorption. The metal-containing TUD-1 materials were tested as solid acid catalysts for the conversion of three bio-based compounds into valuable chem. products. In the conversion of dihydroxyacetone into Et lactate, complete selectivity towards the desired lactate product was achieved with Zr-, Hf- and Sn-TUD-1. The three heterogeneous catalysts displayed similar activity, with Hf-TUD-1 reaching the highest conversion and metal-based turnover number Sn-TUD-1 also displayed high activity and selectivity in two acetalization reactions, i.e. the synthesis of solketal from acetone and glycerol and the reaction of vanillin with propylene glycol. The catalytic performance of these TUD-1 materials is ascribed to the high accessibility of their active sites and to the suitable combination of acid sites. The catalysts were successfully reused in consecutive runs and did not suffer from leaching.

Inorganica Chimica Acta published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, Quality Control of 68527-74-2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Xu, Xiaofeng published the artcileConjugated polyelectrolytes and neutral polymers with poly(2,7-carbazole) backbone: Synthesis, characterization, and photovoltaic application, Name: 9-(6-Bromohexyl)-2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-carbazole, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2011), 49(5), 1263-1272, database is CAplus.

Poly(2,7-carbazole) neutral polymers (PC-N, PC-NOH, and PC-P) and polyelectrolytes (PC-NBr and PC-SO₃Na) with hydrophilic pendant groups of ammonium, phosphonate, and sulfonate were synthesized as interlayers for cathode modifications in bulk-heterojunction photovoltaic cells (BHJ PVCs). The absorptions of the polymers were determined by the poly(2,7-carbazole) backbone, showing absorption peaks at ∼390 nm for their solutions and films. Because of large intermol. interactions, excimer emissions with wavelengths higher than 500 nm were found in the photoluminescence spectra of the films of the polymers, which weakened the light emissions of the polymers. PC-N, PC-NBr, PC-NOH, and PC-P possessed comparable HOMO levels of -5.23 eV and LUMO levels of -2.4 eV, but HOMO and LUMO levels of PC-SO₃Na were up-lying to -4.91 and -2.12 eV, resp. PC-N, PC-NBr, PC-NOH, and PC-P were selected to construct thin interlayers in BHJ PVCs with PFO-DBT35:PCBM = 1:4 as the active layer. Compared with traditional Al cathode, bilayer cathodes with the interlayers showed improvements of open-circuit voltages and short-circuit currents of the PVCs. PC-NOH was the best for the photovoltaic performances and over 20% increase of power conversion efficiency (PCE) was achieved. The bilayer cathodes would have great potential to further elevate PCE of BHJ PVCs with other active layer materials. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 1268162-40-8. 1268162-40-8 belongs to dioxole, auxiliary class Boronic acid and ester,Boronic acid and ester,Bromide, name is 9-(6-Bromohexyl)-2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-carbazole, and the molecular formula is C6H8O4, Name: 9-(6-Bromohexyl)-2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-carbazole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

LeBouf, Ryan F. published the artcileHeadspace analysis for screening of volatile organic compound profiles of electronic juice bulk material, Name: 2,2,4-Trimethyl-1,3-dioxolane, the publication is Analytical and Bioanalytical Chemistry (2018), 410(23), 5951-5960, database is CAplus and MEDLINE.

The use of electronic nicotine delivery systems continues to gain popularity, and there is concern for potential health risks from inhalation of aerosol and vapor produced by these devices. An anal. method was developed that provided quant. and qual. chem. information for characterizing the volatile constituents of bulk electronic cigarette liquids (e-liquids) using a static headspace technique. Volatile organic compounds (VOCs) were screened from a convenience sample of 146 e-liquids by equilibrating 1 g of each e-liquid in amber vials for 24 h at room temperature Headspace was transferred to an evacuated canister and quant. analyzed for 20 VOCs as well as tentatively identified compounds using a preconcentrator/gas chromatog./mass spectrometer system. The e-liquids were classified into flavor categories including brown, fruit, hybrid dairy, menthol, mint, none, tobacco, and other. 2,3-Butanedione was found at the highest concentration in brown flavor types, but was also found in fruit, hybrid dairy, and menthol flavor types. Benzene was observed at concentrations that are concerning given the carcinogenicity of this compound (max 1.6 ppm in a fruit flavor type). The proposed headspace anal. technique coupled with partition coefficients allows for a rapid and sensitive prediction of the volatile content in the liquid The technique does not require onerous sample preparation, dilution with organic solvents, or sampling at elevated temperatures Static headspace screening of e-liquids allows for the identification of volatile chem. constituents which is critical for identifying and controlling emission of potentially hazardous constituents in the workplace.

Analytical and Bioanalytical Chemistry published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Name: 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem