Design, synthesis and anti-rheumatoid arthritis evaluation of double-ring conjugated enones was written by Zhou, Shiyang;Zou, Huiying;Huang, Gangliang;Chen, Guangying;Zhou, Xueming;Huang, Shuheng. And the article was included in Bioorganic Chemistry in 2021.COA of Formula: C8H14O4 The following contents are mentioned in the article:
Four series of double-ring conjugated enones were designed, synthesized and studied for the inhibition of synovial cell activity through the modification of Dysodensiol K core structure, double-ring, double-bond and double-carbonyl groups. For the in vitro synovial cell assay of rats, compound I and II exhibited good inhibitory activities, with IC50 values of 2.71 ± 0.18 and 2.68 ± 0.16μM, resp. At the same time, the LDH release and LD50 test results revealed that the target compounds had low cytotoxicity and acute toxicity. For the in vivo CIA model test through oral administration, compounds I and II exhibited a similar effect to pos. control group methotrexate. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1COA of Formula: C8H14O4).
Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.COA of Formula: C8H14O4
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem